Ottawa Hospital Research Institute

This study aims to find out if patients with bone metastases from breast or prostate cancer can safely reduce or stop their bone-strengthening medications after taking them for over two years. It will compare continuing the drugs versus lowering the dose or stopping them, focusin…

This study tests a community support program designed to help people with tobacco or substance addiction who also face poverty or housing insecurity. The program provides life-skills workshops, peer guidance, and nicotine replacement therapy to see if it improves quality of life …

This is a small pilot study to prepare for a larger trial. It will test if removing nasal polyps in a doctor's office (EPIC) works as well as standard surgery in an operating room (FESS). The goal is to see if the simpler clinic procedure, which is cheaper and has faster recovery…

This study is testing whether a higher dose of the common oral antibiotic cephalexin is better than the standard dose for treating cellulitis, a common and painful skin infection. It involves 446 adults who visit the emergency department and are sent home with pills. The main goa…

This study is testing if a new, gentler schedule for starting hormone therapy pills can help breast cancer patients stick with their treatment. It will compare the standard daily dose to a schedule where patients take the pill every other day for the first month before switching …

This study aims to find the best way to prepare patients for elective colon surgery to reduce infections. It compares two common approaches: taking oral antibiotics the day before surgery versus doing no bowel preparation at all. Researchers will measure infection rates, hospital…

This study is testing whether women aged 70 and older with a specific, lower-risk type of early-stage breast cancer can safely skip hormone-blocking pills after their initial surgery and radiation. The goal is to see if avoiding these medications, which can have significant side …

This study is testing whether patients with early-stage HER2-positive breast cancer who respond very well to initial treatment can safely receive only 6 months of targeted therapy instead of the standard 12 months. Researchers want to see if the shorter treatment works as well wh…

This study tests two practical strategies to help homeless or at-risk adults in Ottawa and Toronto quit or reduce smoking and other substance use. It compares a plant-based medication called Cytisine with standard nicotine replacement therapy (like sprays or gum), both combined w…

This study aims to see if full-body muscle MRI scans can become a better, non-invasive tool for diagnosing rare neuromuscular diseases. Researchers will collect and analyze MRI scans from 1,000 patients across 14 international centers to identify unique patterns of muscle damage …

This study aims to improve the diagnosis and understanding of various rare neuromuscular diseases, which affect muscles and nerves. Researchers will collect blood, tissue samples, and medical data from 500 adults with these conditions. The goal is to find genetic markers and othe…

This research project aims to understand why homeless or at-risk youth in Ottawa use multiple substances like tobacco, cannabis, and other drugs. The study will work directly with about 520 young people and adults, using surveys and interviews to learn about their experiences. Ba…

This study aims to understand the long-term results of minimally invasive surgery for several esophageal conditions, including GERD and achalasia. Researchers will follow 200 patients from a single hospital, checking in annually with questionnaires and reviewing medical records. …