Ottawa Hospital Research Institute

This trial tests a computer tool that automatically calculates a patient's risk of dying within a year when they are admitted to the hospital. The goal is to help doctors reliably identify patients who might have unmet palliative care needs, such as severe symptoms or a desire to…

This study compares two standard approaches for preparing the bowel before elective colon surgery: taking oral antibiotics (neomycin and metronidazole) the day before versus no preparation at all. The goal is to see if the antibiotics reduce surgical site infections within 30 day…

This study looks at whether patients with early-stage HER2-positive breast cancer who have a complete response to initial chemotherapy and HER2-targeted therapy can safely receive only 6 months of further HER2 treatment instead of the standard 12 months. The goal is to reduce hea…

This study compares two approaches to help people who are homeless or at risk of homelessness quit smoking: cytisine (a plant-based pill) versus nicotine replacement therapy (like mouth spray, patches, or gum). Both groups also get counseling. The goal is to see which strategy wo…

This study tests a program called the Bridge Model that provides social support, volunteering, and job opportunities to help people with nicotine or substance use disorders who are homeless or low-income. Researchers want to see if this approach improves quality of life and helps…

This study looks at whether people with breast or prostate cancer that has spread to the bones can safely stop or reduce their bone-strengthening medication after taking it for at least two years. The goal is to see if this change improves their quality of life without increasing…

This study looks at whether starting hormone therapy every other day for one month, then switching to daily, helps women with early breast cancer take their medication as prescribed. About 240 participants will be randomly assigned to either the standard daily dose or the gradual…

This study tests whether very small, daily doses of psilocybin (the active ingredient in magic mushrooms) can safely reduce anxiety and depression in people with advanced illnesses receiving palliative care. Twenty participants will take oral capsules (1-3 mg per day, Monday to F…

This pilot study tests whether a small procedure done in the doctor's office (called EPIC) can work as well as standard sinus surgery for people with chronic sinusitis and nasal polyps. The EPIC procedure is done under local anesthesia and has a shorter recovery time. The study o…

This study looks at tobacco, cannabis, and other drug use among homeless and at-risk youth in downtown Ottawa. Researchers will follow 520 participants aged 16 and older who are homeless or insecurely housed and have a history of cannabis use and mental illness. The goal is to un…

This study follows 200 patients who had minimally invasive surgery for conditions like achalasia, GERD, or hiatal hernia. Each year, patients fill out questionnaires about their symptoms and quality of life, and doctors review their medical records. The goal is to understand how …

This study aims to help doctors diagnose neuromuscular diseases faster and better understand how these conditions progress. Researchers will collect blood, tissue, and imaging data from 500 adults with neuromuscular disease. The goal is to find genetic markers and other clues tha…

This study is collecting MRI scans from 1000 people with neuromuscular diseases to see if muscle imaging can help doctors diagnose these conditions more accurately and without invasive biopsies. The goal is to create a large database of MRI patterns linked to specific genetic cau…