Could a simple drug replace platelet transfusions for stem cell patients?

NCT ID NCT04448184

Recruiting now Disease control Sponsor: Ottawa Hospital Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a drug called tranexamic acid can safely replace routine platelet transfusions in adults receiving a stem cell transplant for blood cancers. About 662 participants will either get tranexamic acid or standard platelet transfusions. The goal is to see if the drug reduces bleeding and is just as safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Tranexamic Acid
What this could lead to: If successful, this could reduce the need for platelet transfusions in stem cell transplant patients, lowering risks and costs while maintaining safety.
What could go wrong: This is a large phase 3 trial, but tranexamic acid may not prevent bleeding as well as transfusions, and there is a small risk of blood clots. Results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEMATOLOGIC NEOPLASMS

Contacts and locations

Locations

Cross Cancer Institute
RECRUITING

Edmonton, Alberta, Canada
Dalhousie University
NOT_YET_RECRUITING

Halifax, Nova Scotia, Canada
Eastern Regional Health Authority
RECRUITING

St. John's, Newfoundland and Labrador, A1B 3V6, Canada
Hamilton Health Sciences - Juravinski Hospital and Cancer Centre
RECRUITING

Hamilton, Ontario, L8V 1C3, Canada
Hopital Maisonneuve-Rosemont
NOT_YET_RECRUITING

Montreal, Quebec, Canada
London Health Sciences Centre
RECRUITING

London, Ontario, N6A5W9, Canada
Memorial University
NOT_YET_RECRUITING

St. John's, Newfoundland and Labrador, Canada
Niagara Health System
RECRUITING

St. Catharines, Ontario, L2S 0A9, Canada
Princess Margaret Cancer Centre
WITHDRAWN

Toronto, Ontario, M5G 2M9, Canada
Saskatchewan Cancer Agency
RECRUITING

Saskatoon, Saskatchewan, Canada
The Ottawa Hospital
RECRUITING

Ottawa, Ontario, K1H8L6, Canada
Tom Baker Cancer Centre
RECRUITING

Calgary, Alberta, T2N4N2, Canada

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