Heartburn drug may shield seniors from bleeding while on blood thinners

NCT ID NCT06393868

Recruiting now Disease control Sponsor: Ottawa Hospital Research Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This pilot study tests whether omeprazole, a common heartburn drug, can reduce gastrointestinal bleeding in adults 65 and older who take blood thinners for blood clots. Researchers will enroll 360 participants to see if a larger trial is feasible. The study focuses on recruitment and adherence, not yet on proving the drug works.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Omeprazole (a proton pump inhibitor)
What this could lead to: If this pilot succeeds, it could lead to a larger study that may show omeprazole helps prevent stomach bleeding in older adults taking blood thinners for blood clots.
What could go wrong: This is a small pilot study to test feasibility, not effectiveness. It may not prove omeprazole works, and results may not apply to all patients. Omeprazole can have side effects like headache or diarrhea.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Gastrointestinal Hemorrhage thrombotic disease venous thromboembolism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLOOD CLOT GASTRO INTESTINAL BLEEDING VENOUS THROMBOEMBOLISM

Contacts and locations

Locations

CHU de Québec-Université Laval; Hôpital Saint-François d'Assise
RECRUITING

Québec, Quebec, G1R2J6, Canada
CIUSSS de l'Est-de- l'Île-de-Montréal
RECRUITING

Montreal, Quebec, H1T2M4, Canada
Centre hospitalier de l'Université de Montréal
RECRUITING

Montreal, Quebec, H2X 0A9, Canada
Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval
RECRUITING

Québec, Quebec, G1V4G5, Canada
Niagara Health System - St. Catharines Site
NOT_YET_RECRUITING

St. Catharines, Ontario, L2S 0A9, Canada
The Ottawa Hospital
RECRUITING

Ottawa, Ontario, K1H 8L6, Canada
University Health Network - Toronto General
RECRUITING

Toronto, Ontario, M5G 2c4, Canada

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