VENOUS THROMBOEMBOLISM

This study is testing two catheter-based devices, Symphony and Prodigy, that remove blood clots from blood vessels in the legs, arms, or lungs. Researchers want to see if these devices can safely restore blood flow and prevent serious outcomes like amputation or heart strain. The…

This study compares a daily pill (rivaroxaban) to daily injections (low-molecular-weight heparin) for preventing blood clots in people with leg injuries that require a cast or brace. About 1,424 high-risk participants will be randomly assigned to one of the two treatments and fol…

This study compares a device that physically removes blood clots from leg veins (ClotTriever) to standard blood-thinning medication alone for people with deep vein thrombosis (DVT). About 300 participants with recent, severe DVT in one leg will be randomly assigned to either trea…

This study compares two approaches for low-risk patients with small blood clots in the lungs (isolated subsegmental pulmonary embolism). Half will receive standard blood-thinning medication (rivaroxaban), while the other half will get a placebo and be closely monitored. The goal …

This study follows 82 people who receive the Celect Platinum Vena Cava Filter, a device placed in a large vein to catch blood clots and prevent them from reaching the lungs. Researchers will track safety and performance for up to 5 years, checking for problems like filter movemen…

This study looks at 200 people who had a bleeding stroke caused by high blood pressure. Doctors want to know if starting blood thinners (heparin) early—within 2 days—or waiting until day 3 is safer and better at preventing blood clots in the legs or lungs. Participants get brain …

This Phase 3 trial tests whether Kinisoquin™, a supplement-like drug made from isoquercetin plus vitamins C and B3, can prevent dangerous blood clots in 480 people with advanced pancreatic cancer. Participants receive either Kinisoquin™ or a placebo alongside their first chemothe…

This pilot study tests whether omeprazole, a common heartburn drug, can reduce gastrointestinal bleeding in adults 65 and older who take blood thinners for blood clots. Researchers will enroll 360 participants to see if a larger trial is feasible. The study focuses on recruitment…

This study is testing whether adding rosuvastatin (a common cholesterol-lowering drug) to standard blood thinner treatment can lower the risk of another blood clot in people who have recently had a deep vein thrombosis or pulmonary embolism. About 2,700 participants will receive …

This study tests an experimental drug called SRSD107 to see if it can prevent blood clots in people having knee replacement surgery. About 450 adults aged 60 to 80 will receive either SRSD107 or the standard blood thinner enoxaparin. The goal is to compare how well each drug prev…

This pilot study is testing whether a low dose of colchicine, a drug usually used for gout, can reduce the risk of post-thrombotic syndrome (PTS) after a deep vein thrombosis (DVT) in the leg. PTS can cause chronic pain, swelling, and skin changes. The trial will enroll 150 adult…

This study tests whether a shared decision-making process, which uses personalized risk scores, can help patients with unprovoked blood clots choose the best duration of blood-thinning medication. The goal is to reduce the chance of another clot or serious bleeding while improvin…

This study tests whether apixaban (a pill taken twice a day) is a safe and more satisfying alternative to enoxaparin (a daily shot) for preventing blood clots after head and neck cancer surgery. About 76 adults will take one of the two medicines for 10 days after surgery. Researc…

After hip or knee replacement, all patients currently get the same dose of blood thinners to prevent clots, but some still get clots while others bleed. This trial will test whether giving a shorter course to low-risk patients and a stronger, longer course to high-risk patients c…

This study tests whether taking a daily statin (rosuvastatin) for one year can safely prevent life-threatening blood clots in people with cancer. Current clot-preventing drugs raise bleeding risks, so a safer option is needed. The trial will enroll 4,000 adults with newly diagnos…

This study tests whether giving blood-thinning medicine after varicose vein surgery can prevent dangerous blood clots in the legs or lungs. About 1 in 50 people develop a clot after these procedures. The trial will enroll 3,175 adults and compare those who receive the medicine to…

This study looks at whether wearing compression stockings in the hospital, on top of taking blood-thinning medication, can further reduce the risk of dangerous blood clots after surgery. About 8,600 adults having high-risk operations (like cancer or joint surgery) will be randoml…

This study looks at whether taking 81 mg of aspirin once a day works just as well as taking it twice a day to prevent dangerous blood clots after hip or knee replacement surgery. About 5,500 adults having joint replacement will be randomly assigned to one of the two dosing schedu…

This study tests whether a computer alert can help doctors remember to prescribe blood-thinning medicine for high-risk patients after they leave the hospital. Blood clots are a serious risk for some hospitalized patients, even after discharge. The trial will include 400 adults ag…

This study is testing whether the blood thinner apixaban can safely prevent blood clots in people newly diagnosed with a fast-growing brain tumor called grade 4 glioma. About 40 adults will take apixaban while receiving standard radiation and chemotherapy. The main goal is to see…

This study compares how a 60-minute treadmill walk changes blood clotting in people who have had a blood clot (venous thromboembolism) and those who haven't. Researchers will measure clotting markers before and after exercise in 94 participants. The goal is to better understand h…

This study looks at 665 people who had a pulmonary embolism (a blood clot in the lung) and are at intermediate risk of another clot. Researchers will use a special 3D lung scan (V/Q SPECT/CT) to measure leftover blockages in lung blood vessels. The goal is to see if this scan can…

This study is testing a new radioactive tracer designed to attach to active blood clots and make them visible on a PET scan. Researchers will take blood samples from 10 healthy volunteers, create clots in the lab, and see how well the tracer binds to them. The goal is to develop …

Cancer patients face a higher risk of blood clots during chemotherapy, but it's hard to know who is most at risk. This study will measure clotting-related biomarkers in the blood of 380 patients with ovarian, lung, stomach, or pancreatic cancer at four points during their treatme…

This study is testing a software tool that uses DNA from a blood sample to predict the risk of blood clots returning in people with cancer who have finished 3-12 months of blood thinner treatment. The goal is to see if a low-risk result means it's safe to stop blood thinners with…

This study looks at how often lung cancer patients on immune checkpoint inhibitors develop blood clots (in veins or arteries) and what factors increase that risk. Researchers will follow 2,400 adults with lung cancer who are starting immunotherapy, comparing those who get clots w…

This study is a registry that follows up to 10,000 people who have been diagnosed with a blood clot (deep vein thrombosis or pulmonary embolism) and started blood-thinning medication within 14 days. Researchers at the Mayo Clinic will track how many patients have another clot or …

This study tests whether a clinical decision support (CDS) system can help doctors follow best-practice guidelines for preventing venous thromboembolism (blood clots) in adults with traumatic brain injury. Researchers will compare hospitals that use the CDS system with those that…

This study aims to validate the Caprini score, a tool that estimates blood clot risk, in 3,000 people undergoing varicose vein surgery. Participants will be followed for four weeks after procedures like laser treatment or vein stripping to see if the score accurately predicts who…

This study aims to understand if COVID-19 vaccines have any impact on brain health in healthy people. Researchers will use MRI scans to look for changes in the brain's blood vessels and structure. The study will follow 500 adults from Hong Kong who have already had a baseline bra…

This study is not testing a new drug or treatment. Instead, researchers are combining health information from 20,000 people across 14 European groups who have had blood clots (venous thromboembolism). By merging this data, they hope to better understand who is at risk for future …

This study follows 825 pregnant women who need blood thinners for blood clots, observing how these medications are managed around labor and delivery. Researchers aim to see how different strategies affect bleeding risks. The goal is to find safer ways to handle blood thinners dur…

This study is a large registry that collects detailed information from 120,000 patients with venous thromboembolism (blood clots). The goal is to help doctors better understand the disease and identify who is at highest risk for complications like bleeding or another clot. By inc…

This study is a registry that follows up to 5,000 adults who have an IVC filter placed or removed. An IVC filter is a small device placed in a large vein to prevent blood clots from traveling to the lungs. The goal is to collect data on how well the filter works and any complicat…

This study tests whether a set of quality improvement tools—including guidelines, care protocols, and a mobile app—can help hospitals in China better prevent blood clots in patients. About 5,800 hospitalized adults will take part across multiple hospitals. The goal is to see if t…