VENOUS THROMBOEMBOLISM

This large Phase 3 trial is testing whether adding the cholesterol-lowering drug rosuvastatin to standard blood thinners can help prevent dangerous blood clots from returning. The study will enroll 2,700 adults who recently had a major leg or lung clot, giving half the participan…

This study is testing a new software tool that analyzes DNA from a simple blood test. The goal is to see if this tool can accurately predict which cancer patients are at low risk for their blood clots returning. If successful, it could help doctors safely stop blood thinner medic…

This study is testing if a low daily dose of colchicine, an anti-inflammatory drug, can prevent a painful long-term condition called post-thrombotic syndrome (PTS) after a serious leg blood clot (DVT). It will involve 150 adults who have just been diagnosed with a DVT. Participan…

This study is monitoring two types of blood clot filters that doctors place in patients at risk for dangerous lung clots. Researchers will follow 82 patients for up to 5 years to check if the filters remain safe and effective over time. The study focuses on whether the filters ca…

This study is testing two medical devices, Symphony and Prodigy, that are designed to remove dangerous blood clots from arteries and veins. It will enroll 750 adults who have blood clots in their limbs or lungs. The main goal is to see how well these devices work and how safe the…

This study is testing a medical device called the Cleaner™ Pro Thrombectomy System that physically removes blood clots from the lungs of patients with acute pulmonary embolism (a dangerous lung clot). Researchers want to see if using this suction device is safe and helps improve …

This study is testing a new decision-making tool to help patients and doctors decide how long to continue blood thinners after a first unprovoked blood clot. The goal is to better balance the risk of another clot against the risk of serious bleeding. It involves 2,400 adults who …

This study is testing whether a new procedure to physically remove blood clots from the leg's large veins works better than just using blood-thinning medication. It aims to see if removing the clot early helps patients avoid long-term pain, swelling, and other complications. Abou…

This study is testing a computer alert system in hospital electronic records. The goal is to remind doctors to prescribe medication that helps prevent dangerous blood clots for high-risk patients after they go home. The trial will enroll 400 hospitalized patients with conditions …

This study is testing if a common heartburn medicine called omeprazole can prevent stomach and intestinal bleeding in adults 65 and older who are taking blood thinners for a recent blood clot. It's a pilot study to see if a larger trial is possible. Some participants will get ome…

This large national study is testing if customizing blood thinner treatment after hip or knee replacement surgery is safer and more effective than the current standard approach. Researchers will assign over 10,000 patients to receive shorter, longer, or standard treatment based o…

This study aims to find the best aspirin dose to prevent dangerous blood clots after hip or knee replacement surgery. It will compare taking one low-dose aspirin pill per day versus taking two. The goal is to determine which schedule is more effective and safer for patients recov…

This study is testing if a daily pill (rivaroxaban) works as well as or better than daily injections (LMWH) at preventing dangerous blood clots in people with serious leg injuries who need a cast or brace. It focuses on patients identified as high-risk for clots. Researchers will…

This large UK study aims to find out if wearing compression stockings in the hospital provides any extra benefit for preventing blood clots when patients are already taking extended blood-thinning medication after high-risk surgery. It will enroll over 8,600 patients to compare t…

This study is testing if the blood-thinning medication apixaban can safely prevent dangerous blood clots in people newly diagnosed with aggressive brain tumors (grade 4 glioma). It will involve about 40 adult patients who are starting radiation and chemotherapy. The main goal is …

This study is testing a new investigational drug, SRSD107, to see if it works better and is as safe as the standard blood thinner (enoxaparin) at preventing dangerous blood clots after knee replacement surgery. It will involve about 450 adults aged 60-80 who are scheduled for thi…

This large study is testing whether a hospital-wide quality improvement program can help prevent dangerous blood clots in patients during and after their hospital stay. It will involve 5,800 patients across multiple hospitals in China. Some hospitals will use the new program, whi…

This study is testing if a drug called Kinisoquin™ can prevent dangerous blood clots in people with advanced pancreatic cancer who are starting chemotherapy. About 480 patients will receive either the study drug or a placebo for 16 weeks to see which group has fewer clots. The go…

This study is testing if a pill (apixaban) is a safe and easier-to-use alternative to a daily injection (enoxaparin) for preventing dangerous blood clots after head and neck cancer surgery. It will enroll about 76 patients who are scheduled for surgery. The main goal is to see if…

This study is creating a large database of patients with venous thromboembolism (blood clots) to better understand how the disease progresses in real-world settings. It focuses on groups often excluded from other trials, like pregnant women, elderly patients, and those with cance…

This study is creating a large registry to collect information on patients who have a device called an IVC filter placed or removed to prevent blood clots. The goal is to track how patients do over time to better understand the long-term safety and effectiveness of these filters,…

This study is testing whether a computer-based decision support system can help doctors better prevent dangerous blood clots (venous thromboembolism) in patients hospitalized with traumatic brain injury. The research will involve 15,000 adult patients across seven hospitals. The …

This study aims to combine medical information from 14 different European patient groups into one large database. Researchers will analyze this combined data to better understand and predict risks like recurring blood clots, bleeding complications, and death. The goal is to help …

This study aims to understand how blood thinners are managed around childbirth in pregnant women with a history of blood clots. Researchers will follow 825 women to track bleeding risks, new clot formation, and patient experiences during delivery and recovery. The goal is to gath…

This study aims to understand if COVID-19 vaccines affect brain health, specifically looking for signs of stroke or dementia. Researchers in Hong Kong will follow 500 healthy adults, comparing brain scans and memory tests from before and after vaccination to those from unvaccinat…

This study aims to test how well a risk-scoring tool (the Caprini score) can predict dangerous blood clots in the legs or lungs after varicose vein surgery. It will follow 3,000 patients for a month after their procedure, using ultrasound scans to check for clots. The goal is to …