Hidden clots in heart failure? new study tests routine screening

NCT ID NCT07499661

Recruiting now Diagnosis Sponsor: University Hospital, Angers Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This study looks at whether blood clots in the lungs (pulmonary embolism) are often missed in people hospitalized with acute heart failure. About 740 patients across multiple hospitals will take part. In half the hospitals, doctors will follow their usual approach; in the other half, they will systematically test every patient for a clot using a standard diagnostic checklist. The goal is to see if routine testing leads to more diagnoses and better outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Systematic diagnostic algorithm for pulmonary embolism (including Geneva score, D-dimer testing, and imaging)
What this could lead to: If successful, this could show that routine screening for blood clots in the lungs is worthwhile for all patients hospitalized with acute heart failure, leading to earlier treatment and fewer complications.
What could go wrong: This is a pragmatic trial testing a diagnostic strategy, not a new treatment. The expected increase in detection is modest (from 1% to 5%), and it may not translate into better survival or fewer hospital readmissions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

disease heart failure pulmonary embolism venous thromboembolism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE HEART FAILURE (AHF) PULMONARY EMBOLISM (DIAGNOSIS) VENOUS THROMBOEMBOLISM

Contacts and locations

Locations

Agen Hospital, Emergency department
NOT_YET_RECRUITING

Agen, 47923, France
Angers University Hospital, Emergency Department
RECRUITING

Angers, 49000, France
Brest University Hospital (site Cavale Blanche), Cardiology Department
NOT_YET_RECRUITING

Brest, 29200, France
Cholet Hospital, Emergency Department
NOT_YET_RECRUITING

Cholet, 49300, France
Clermont-Ferrand University Hospital, Emergency Department
NOT_YET_RECRUITING

Clermont-Ferrand, 63000, France
Grenoble Alpes University Hospital, Adult Emergency Department
NOT_YET_RECRUITING

La Tronche, 38700, France
Lyon University Hospital (site Edouard Herriot), Emergency Department
NOT_YET_RECRUITING

Lyon, 69003, France
Poitiers University Hospital, Emergency Department
NOT_YET_RECRUITING

Poitiers, 86000, France
Toulouse University Hospital, Emergency Department
NOT_YET_RECRUITING

Toulouse, 31000, France
Tours University Hospital (site Trousseau), Adult Emergency Department
NOT_YET_RECRUITING

Chambray-lès-Tours, 37170, France

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