PULMONARY EMBOLISM

This study is testing two catheter-based devices, Symphony and Prodigy, that remove blood clots from blood vessels in the legs, arms, or lungs. Researchers want to see if these devices can safely restore blood flow and prevent serious outcomes like amputation or heart strain. The…

This study compares a daily pill (rivaroxaban) to daily injections (low-molecular-weight heparin) for preventing blood clots in people with leg injuries that require a cast or brace. About 1,424 high-risk participants will be randomly assigned to one of the two treatments and fol…

This study compares a device called FlowTriever (used with blood thinners) to blood thinners alone for people with intermediate-risk pulmonary embolism (blood clots in the lungs). About 1,200 adults with clots in major lung arteries and signs of heart strain will be randomly assi…

This study is testing a device called FlowTriever that removes blood clots from the lungs in people with a severe, high-risk pulmonary embolism. About 200 participants will be randomly assigned to get either the device or standard care. The goal is to see if the device reduces de…

This study compares two approaches for low-risk patients with small blood clots in the lungs (isolated subsegmental pulmonary embolism). Half will receive standard blood-thinning medication (rivaroxaban), while the other half will get a placebo and be closely monitored. The goal …

This study tests whether using a catheter to remove blood clots from the lungs, along with standard blood thinners, helps people with submassive pulmonary embolism recover better than blood thinners alone. About 500 adults with large clots and an enlarged right heart chamber will…

This study is testing a device called the Indigo Aspiration System to remove blood clots from the lungs in people with a pulmonary embolism. The goal is to see if it is safe and helps patients recover better in the long run. About 1500 adults with recent clots will take part.

This study follows 82 people who receive the Celect Platinum Vena Cava Filter, a device placed in a large vein to catch blood clots and prevent them from reaching the lungs. Researchers will track safety and performance for up to 5 years, checking for problems like filter movemen…

This study tracks 180 people who had a serious but stable pulmonary embolism (a blood clot in the lung) and received a treatment that uses ultrasound waves to help a clot-busting drug work better. The main goal is to see if this approach reduces the chance of developing pulmonary…

This study looks at 200 people who had a bleeding stroke caused by high blood pressure. Doctors want to know if starting blood thinners (heparin) early—within 2 days—or waiting until day 3 is safer and better at preventing blood clots in the legs or lungs. Participants get brain …

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This study is testing whether adding rosuvastatin (a common cholesterol-lowering drug) to standard blood thinner treatment can lower the risk of another blood clot in people who have recently had a deep vein thrombosis or pulmonary embolism. About 2,700 participants will receive …

This study tests a single injection of a clot-dissolving drug (staphylokinase) in 486 adults with intermediate high-risk pulmonary embolism—a serious blood clot in the lungs. The goal is to see if it prevents death, heart collapse, or another clot compared to a placebo. Participa…

This study tests a new device called the Laguna Thrombectomy System to remove blood clots from the lungs in people with pulmonary embolism. About 107 adults with moderate to severe clots will be treated, and doctors will check for safety and effectiveness within 48 hours. The goa…

This trial is testing a device called AlphaVac that suctions blood clots out of the lung arteries in people with acute pulmonary embolism (PE). The study will enroll 256 adults with a confirmed PE and signs of heart strain. The main goals are to see if the device reduces heart st…

After hip or knee replacement, all patients currently get the same dose of blood thinners to prevent clots, but some still get clots while others bleed. This trial will test whether giving a shorter course to low-risk patients and a stronger, longer course to high-risk patients c…

This study is testing whether a simple bedside heart ultrasound can help predict which emergency patients with a pulmonary embolism (a blood clot in the lung) are likely to have serious complications within the next few days. Researchers will perform the ultrasound on 250 patient…

This study tests a new bedside tool called Adjust-Unlikely to safely reduce unnecessary imaging for pulmonary embolism (a blood clot in the lungs) in emergency patients. Researchers will enroll 4,000 adults in Canada to see if the tool accurately identifies who does not need a sc…

This study looks at whether two simple checklists (PERC and YEARS) can safely reduce the number of CT scans needed to diagnose pulmonary embolism (a blood clot in the lungs). Researchers will review the records of 500 adults who came to the emergency room with suspected clots. If…

This study is testing a new portable X-ray machine called Dynamic Digital Radiography (DDR) that takes 15 images per second to show how the lungs move and blood flows. Researchers at Brigham and Women's Hospital will use it on 230 ICU patients with various lung conditions to see …

This trial tests whether doing ultrasound scans twice a week on critically ill patients can catch deep-vein thrombosis (DVT) early. The goal is to prevent pulmonary embolism (a clot in the lung) and reduce deaths within 90 days. The study will enroll 1,800 adults in the ICU who a…

This study tests whether a 3-month pulmonary rehabilitation program (20 sessions of exercise and education) can improve quality of life and reduce breathlessness in people who have had a pulmonary embolism. Researchers will enroll 112 adults who still have symptoms at least 3 mon…

This study looks at whether a computer-assisted vacuum procedure to remove blood clots from the lungs is safe and improves quality of life for cancer patients with a moderate-risk pulmonary embolism. About 25 adults with cancer and a confirmed clot in a major lung artery will tak…

This study tests whether a 6-week outpatient pulmonary rehabilitation program helps people with post-PE syndrome (lingering symptoms after a pulmonary embolism) walk farther and breathe better. About 48 adults who had a pulmonary embolism 12 to 36 weeks earlier will be randomly a…

This observational study will follow 1300 critically ill adults in intensive care to see if a blood test called anti-factor Xa activity can predict dangerous blood clots (deep vein thrombosis or pulmonary embolism). Researchers will also track bleeding risks, quality of life, and…

This study uses artificial intelligence to group patients who have had a pulmonary embolism (a blood clot in the lung) based on their medical information at diagnosis. Researchers will track 2,500 patients for 6 months to see how different groups recover. The goal is to help doct…

This study looks at 32 people who still have shortness of breath or reduced quality of life after a pulmonary embolism (a blood clot in the lungs). They will receive a special PET/CT scan before and after a pulmonary rehabilitation program to see how the treatment improves lung f…

This study looks at 665 people who had a pulmonary embolism (a blood clot in the lung) and are at intermediate risk of another clot. Researchers will use a special 3D lung scan (V/Q SPECT/CT) to measure leftover blockages in lung blood vessels. The goal is to see if this scan can…

This study looks at whether a simple heart ultrasound can help predict which patients with a blood clot in the lungs (pulmonary embolism) are at higher risk for serious problems. Researchers will check right heart function in 112 adults and track outcomes like breathing failure, …

This registry will follow 1000 adults with pulmonary embolism (blood clots in the lungs) who are treated with Inari Medical devices. Researchers will track device-related complications and deaths to understand how safe these tools are in everyday use. The study is observational, …

This study is testing a software tool that uses DNA from a blood sample to predict the risk of blood clots returning in people with cancer who have finished 3-12 months of blood thinner treatment. The goal is to see if a low-risk result means it's safe to stop blood thinners with…

This study is testing whether a simple one-minute chair stand test can help doctors predict how well patients will recover from a non-severe pulmonary embolism (a blood clot in the lungs). Researchers will compare the test results with standard risk scores that use blood tests an…

This study looks at whether a special blood test, called a thrombin generation assay, can predict bleeding risk in cancer patients who are taking blood thinners for blood clots. Researchers will follow 212 patients for 6 months, measuring their blood's clotting ability and tracki…

This study is tracking 220 adults across Nordic countries who receive either clot-dissolving drugs or a catheter-based procedure for a severe pulmonary embolism. Researchers are comparing how often each treatment leads to serious bleeding or death within 30 days. The goal is to p…

This study looks at 100 adults hospitalized in the ICU for a serious pulmonary embolism (a blood clot in the lung). Researchers want to know how long it takes for the blood thinner (unfractionated heparin) to reach a level that prevents more clots. They will also check if faster …

This study tests whether a set of quality improvement tools—including guidelines, care protocols, and a mobile app—can help hospitals in China better prevent blood clots in patients. About 5,800 hospitalized adults will take part across multiple hospitals. The goal is to see if t…