PULMONARY EMBOLISM

This study tests whether giving each patient a tailored dose and duration of blood thinners after hip or knee replacement works better than the standard approach. About 10,000 adults will be assigned to shorter treatment if they have low clot risk, or stronger/longer treatment if…

This study tests a device called AlphaVac that is used to remove blood clots from the lungs in people with acute pulmonary embolism (a sudden blockage in the lung artery). About 256 adults with confirmed clots and signs of heart strain will be enrolled. The goal is to see if the …

This study compares two treatments for people with a moderate-risk pulmonary embolism (a blood clot in the lung). One group gets standard blood thinners alone, while the other gets a device called FlowTriever that removes the clot plus blood thinners. The goal is to see which app…

This study is testing a device called the Indigo Aspiration System to remove blood clots from the lungs in people with pulmonary embolism (PE). The goal is to see if it is safe and works well over the long term. About 1500 adults with acute PE will be enrolled. The study will tra…

This study compares a new device called FlowTriever to standard treatments for people with a severe type of blood clot in the lungs (high-risk pulmonary embolism). The goal is to see if the device can lower the chances of death, heart stopping, major bleeding, or needing a breath…

This study compares two blood thinners—rivaroxaban (a pill) and low-molecular-weight heparin (a daily injection)—in people with leg injuries that require a cast or brace for at least two weeks. The goal is to see if the pill is as good as or better than the injection at preventin…

This study tests two medical devices (Symphony and Prodigy) that remove blood clots from arteries, veins, or the lungs. About 750 adults will be enrolled to see if the devices safely improve blood flow and prevent serious problems like amputation or re-clotting. The goal is to ma…

This study is checking the long-term safety and performance of a device called the Celect Platinum Vena Cava Filter, which is placed in a large vein to catch blood clots and prevent them from reaching the lungs. About 82 people who already have or will get this filter will be fol…

This study tests a program to help low-income people with multiple chronic conditions take their medications correctly after leaving the hospital. The program provides free medications, delivers them to the bedside and home, and offers support from pharmacy staff. Researchers wil…

This study tests whether using a catheter to remove blood clots from the lungs, along with standard blood thinners, helps people with submassive pulmonary embolism recover better than blood thinners alone. About 500 adults with large clots and an enlarged right heart chamber will…

This study tests a single-dose medicine (staphylokinase) to see if it can prevent death, heart failure, or repeat blood clots in people with a serious type of pulmonary embolism. About 486 adults with intermediate high-risk clots will receive either the drug or a placebo. The goa…

This study tests a new device called the Laguna Thrombectomy System to remove blood clots from the lungs in people with pulmonary embolism. About 107 adults with a recent clot and stable blood pressure will receive the procedure. The goal is to see if the device safely reduces cl…

This study aims to see if a new bedside tool called Adjust-Unlikely can safely reduce the number of unnecessary imaging tests for pulmonary embolism (a blood clot in the lungs) in emergency patients. Currently, many patients are tested with scans that expose them to radiation and…

This study looks at whether two checklists (PERC and YEARS) can help doctors decide who really needs a CT scan for a blood clot in the lungs. Researchers will review records of 500 adults from one hospital's ER to see how many scans could have been avoided. The goal is to make di…

This study tests a new portable X-ray machine that takes moving images of the lungs at the bedside in the ICU. It aims to see if this technology can give doctors better information about lung function and blood flow compared to standard X-rays. About 230 adults with various lung …

This study is testing whether doing regular leg ultrasound scans on critically ill patients in intensive care can help detect dangerous blood clots (deep vein thrombosis) early. Finding clots early might prevent them from traveling to the lungs (pulmonary embolism) and potentiall…

This study looks at 200 people with high-blood-pressure-related brain bleeding to find the best time to start blood thinners (heparin) to prevent dangerous clots in the legs or lungs. Some participants start heparin within 2 days of admission, others wait until day 3. The goal is…

This study tests if a 6-week outpatient pulmonary rehabilitation program can improve breathing and walking ability in people with post-PE syndrome, a condition where symptoms like shortness of breath persist after a pulmonary embolism. About 48 adults will be randomly assigned to…

This study is for cancer patients who have a blood clot and are taking blood thinners. These drugs can cause dangerous bleeding. Researchers want to see if a special blood test can predict who is at higher risk for bleeding. The study will follow 212 patients for 6 months to chec…

This study looks at how fast blood thinners reach effective levels in ICU patients with a dangerous blood clot in the lungs (pulmonary embolism). Researchers will review records of 100 adults treated between 2014 and 2023 to see if quicker treatment affects survival, clot return,…

This study is a global registry that will follow 1,000 adults who have already been treated with an Inari Medical device for pulmonary embolism (a blood clot in the lungs). The goal is to collect real-world data on device safety, such as side effects or complications. Participant…

This study tests whether a hospital-wide quality improvement program can increase the use of blood clot prevention methods (like blood thinners or compression devices) in hospitalized patients. About 5,800 adults across multiple hospitals in China will take part. The goal is to s…

This study uses artificial intelligence to group patients who have had a pulmonary embolism (a blood clot in the lung) based on their medical information at diagnosis. The goal is to see if these groups have different outcomes six months later, such as recurrence or long-term com…

This study follows 220 adults in Nordic countries who receive either clot-busting drugs or a catheter procedure for severe pulmonary embolism (blood clots in the lungs). Researchers will compare rates of serious bleeding and death within 30 days to see which treatment works bette…

This study looks at whether a one-minute chair lift test can help doctors predict how well patients with non-severe pulmonary embolism (a blood clot in the lungs) will recover. Researchers will compare the test results with standard risk scores and heart markers. The goal is to f…

This study looks at how well a treatment called ultrasound-assisted catheter-directed thrombolysis works for people with serious blood clots in the lungs (intermediate-high-risk pulmonary embolism). Researchers will track 180 participants for 6 months to see how many develop high…

This study observes 1,300 critically ill ICU patients to see if the level of a blood thinner (enoxaparin) in their blood is linked to dangerous blood clots. Researchers will track clots, bleeding, and patient outcomes like survival and hospital stay length. The goal is to find be…