PULMONARY EMBOLISM

This study aims to see if giving blood thinners based on a person's individual risk—rather than a standard dose for everyone—can lower the chance of dangerous blood clots and bleeding after hip or knee replacement. About 10,000 adults scheduled for joint replacement will be assig…

This study compares two blood thinners—rivaroxaban (a pill) and low-molecular-weight heparin (a daily injection)—in people with leg injuries that require a cast or brace for at least two weeks. The goal is to see if the pill is as good as or better than the injection at preventin…

This study compares a device that removes blood clots from the lungs (FlowTriever) plus standard blood thinners to blood thinners alone. About 1,200 people with intermediate-risk pulmonary embolism will take part. The goal is to see if the device reduces death, hospital readmissi…

This study is checking the long-term safety and performance of a device called the Celect Platinum Vena Cava Filter, which is placed in a large vein to catch blood clots and prevent them from reaching the lungs. About 82 people who already have or will get this filter will be fol…

This study tests a program to help low-income people with multiple chronic conditions take their medications correctly after leaving the hospital. The program provides free medications, delivers them to the bedside and home, and offers support from pharmacy staff. Researchers wil…

This study compares a new device called FlowTriever to standard treatments for people with a severe type of blood clot in the lungs (high-risk pulmonary embolism). The goal is to see if the device can lower the chances of death, heart stopping, major bleeding, or needing a breath…

This study tests a device that suctions blood clots out of the lungs in people with a severe type of pulmonary embolism (a blockage in the lung artery). About 256 adults with symptoms for up to 14 days will be enrolled. The goal is to see if the procedure safely reduces clot burd…

This study is testing two medical devices, Symphony and Prodigy, that remove blood clots from arteries, veins, or the lungs. About 750 adults who need a clot-removal procedure will be followed to see if the devices safely restore blood flow and prevent serious problems like amput…

This study tests whether using a catheter to remove blood clots from the lungs, along with standard blood thinners, helps people with submassive pulmonary embolism recover better than blood thinners alone. About 500 adults with large clots and an enlarged right heart chamber will…

This study is testing a device called the Indigo Aspiration System to remove blood clots from the lungs in people with a serious condition called pulmonary embolism. About 1,500 adults with recent symptoms will be treated and followed to see if the device improves breathing, qual…

This study tests a single-dose medicine (staphylokinase) to see if it can prevent death, heart failure, or repeat blood clots in people with a serious type of pulmonary embolism. About 486 adults with intermediate high-risk clots will receive either the drug or a placebo. The goa…

This study tests a new device called the Laguna Thrombectomy System to remove blood clots from the lungs in people with pulmonary embolism. About 107 adults with a recent clot and stable blood pressure will receive the procedure. The goal is to see if the device safely reduces cl…

This study aims to see if a new bedside tool called Adjust-Unlikely can safely reduce the number of unnecessary imaging tests for pulmonary embolism (a blood clot in the lungs) in emergency patients. Currently, many patients are tested with scans that expose them to radiation and…

This study looks at whether two checklists (PERC and YEARS) can help doctors decide who really needs a CT scan for a blood clot in the lungs. Researchers will review records of 500 adults from one hospital's ER to see how many scans could have been avoided. The goal is to make di…

This study tests a new portable X-ray machine that takes moving images of the lungs at the bedside in the ICU. It aims to see if this technology can give doctors better information about lung function and blood flow compared to standard X-rays. About 230 adults with various lung …

This study is testing whether doing regular leg ultrasound scans on critically ill patients in intensive care can help detect dangerous blood clots (deep vein thrombosis) early. Finding clots early might prevent them from traveling to the lungs (pulmonary embolism) and potentiall…

This study looks at the best time to start blood thinners (heparin) in people who have had a brain bleed due to high blood pressure. The goal is to prevent dangerous blood clots in the legs or lungs without causing more bleeding in the brain. About 200 participants will be random…

This study tests whether a 6-week outpatient pulmonary rehabilitation program helps people with post-PE syndrome (lingering symptoms after a pulmonary embolism) feel better and walk farther. About 48 adults who had a pulmonary embolism 12 to 36 weeks earlier will be randomly assi…

This study tests whether a hospital-wide quality improvement program can increase the use of blood clot prevention methods (like blood thinners or compression devices) in hospitalized patients. About 5,800 adults across multiple hospitals in China will take part. The goal is to s…

This study is a global registry that will follow 1,000 adults who have already been treated with an Inari Medical device for pulmonary embolism (a blood clot in the lungs). The goal is to collect real-world data on device safety, such as side effects or complications. Participant…

This study looks at how quickly blood thinners start working in ICU patients with serious pulmonary embolism (blood clots in the lungs). Researchers will review past records of 100 adults treated at one hospital to measure the time it takes to reach effective anticoagulation. The…

This study uses artificial intelligence to group patients who have had a pulmonary embolism (a blood clot in the lung) based on their medical information at diagnosis. The goal is to see if these groups have different outcomes six months later, such as recurrence or long-term com…

This study is testing whether a special blood test (thrombin generation assay) can help predict which cancer patients with blood clots are at higher risk of bleeding while taking blood thinners. Researchers will follow 212 patients for 6 months to see if the test results match bl…

This study follows 220 adults in Nordic countries who receive either clot-busting drugs or a catheter procedure for severe pulmonary embolism (blood clots in the lungs). Researchers will compare rates of serious bleeding and death within 30 days to see which treatment works bette…

This study looks at whether a one-minute chair lift test can help doctors predict how well patients with non-severe pulmonary embolism (a blood clot in the lungs) will recover. Researchers will compare the test results with standard risk scores and heart markers. The goal is to f…

This study looks at how well a treatment called ultrasound-assisted catheter-directed thrombolysis works for people with serious blood clots in the lungs (intermediate-high-risk pulmonary embolism). Researchers will track 180 participants for 6 months to see how many develop high…

This study observes 1,300 critically ill ICU patients to see if the level of a blood thinner (enoxaparin) in their blood is linked to dangerous blood clots. Researchers will track clots, bleeding, and patient outcomes like survival and hospital stay length. The goal is to find be…