New catheter aims to treat dangerous blood clots in the lungs without ICU stay
NCT ID NCT06433011
First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time
Summary
This trial tests a special catheter that delivers clot-dissolving medication directly into the lung arteries of people with intermediate-risk pulmonary embolism. The goal is to see if this targeted approach can safely treat the clot without needing intensive care or a continuous drug drip. About 500 participants will receive the treatment and be followed for 7 to 30 days.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a catheter that delivers clot-busting drugs directly into the pulmonary arteries
- What this could lead to
- If successful, this approach could offer a less invasive treatment for pulmonary embolism that avoids intensive care and reduces complications.
- What could go wrong
- This is an early-stage device trial with 500 participants, so results may not apply to all patients. Risks include bleeding, vessel damage, or the procedure not improving outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Beth Israel Deaconess Medical Center
RECRUITINGBoston, Massachusetts, 02481, United States
Contact Phone: •••-•••-••••
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Boston Medical Center
RECRUITINGBoston, Massachusetts, 02135, United States
Contact Phone: •••-•••-••••
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Carondelet St. Joseph's Hospital
RECRUITINGTuscon, Arizona, 85711, United States
Contact Phone: •••-•••-••••
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Charleston Area Medical Center
RECRUITINGCharleston, West Virginia, 25304, United States
Contact Phone: •••-•••-••••
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Community Health
RECRUITINGIndianapolis, Indiana, 46256, United States
Contact Phone: •••-•••-••••
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Cooper Health
RECRUITINGCamden, New Jersey, 08103, United States
Contact Phone: •••-•••-••••
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Dartmouth Hitchcock
RECRUITINGLebanon, New Hampshire, 03756, United States
Contact Phone: •••-•••-••••
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Emory University
RECRUITINGAtlanta, Georgia, 30308, United States
Contact Phone: •••-•••-••••
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Honor Health
RECRUITINGScottsdale, Arizona, 85258, United States
Contact Phone: •••-•••-••••
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Jobst Vascular Institute - ProMedica Hospital
RECRUITINGToledo, Ohio, 43606, United States
Contact Phone: •••-•••-••••
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Lahey Hospital & Medical Center
RECRUITINGBurlington, Massachusetts, 01805, United States
Contact Phone: •••-•••-••••
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Miami Valley/Wright State University/Premier Health
RECRUITINGDayton, Ohio, 45435, United States
Contact Phone: •••-•••-••••
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Mount Sinai
RECRUITINGNew York, New York, 10029, United States
Contact Phone: •••-•••-••••
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North Mississippi Medical Center
RECRUITINGTupelo, Mississippi, 38801, United States
Contact Phone: •••-•••-••••
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Northwell Health
RECRUITINGManhasset, New York, 11030, United States
Contact Phone: •••-•••-••••
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Profound Research
RECRUITINGHobart, Indiana, 46342, United States
Contact
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Radiology and Imaging Specialists
RECRUITINGLakeland, Florida, 33801, United States
Contact Phone: •••-•••-••••
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Rush University Medical Center
RECRUITINGChicago, Illinois, 60612, United States
Contact Phone: •••-•••-••••
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Sentara
RECRUITINGNorfolk, Virginia, 23507, United States
Contact Phone: •••-•••-••••
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St. Joseph's
RECRUITINGLiverpool, New York, 13088, United States
Contact Phone: •••-•••-••••
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Temple University
RECRUITINGPhiladelphia, Pennsylvania, 19140, United States
Contact Phone: •••-•••-••••
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TriHealth
RECRUITINGCincinnati, Ohio, 45242, United States
Contact Phone: •••-•••-••••
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Vanderbilt University Medical Center
RECRUITINGNashville, Tennessee, 37232, United States
Contact Phone: •••-•••-••••
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Other studies related to the condition(s) this trial covers.
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- Timing of blood thinners after childbirth bleeding may prevent clots without causing more harm
- New antibody aims to dissolve lung clots with less bleeding risk
- Could a lower dose of a Clot-Buster be safer and still effective for dangerous blood clots in the lungs?
- Catheter-Directed Clot-Busting may offer safer option for dangerous blood clots in the lungs