New Clot-Busting catheter procedure could ease recovery for lung blood clot patients

NCT ID NCT05591118

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether using a catheter to remove blood clots from the lungs, along with standard blood thinners, helps people with submassive pulmonary embolism recover better than blood thinners alone. About 500 adults with large clots and an enlarged right heart chamber will be randomly assigned to one of two groups. The goal is to see if the catheter procedure improves exercise ability and heart function while keeping bleeding risks low.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Advocate Good Samaritan Hospital

    RECRUITING

    Downers Grove, Illinois, 60515, United States

  • Baptist Health Miami Cardiac & Vascular Institute

    RECRUITING

    Miami, Florida, 33176, United States

  • Beth Israel Deaconess Medical Center

    RECRUITING

    Boston, Massachusetts, 02215, United States

  • Boston Medical Center

    RECRUITING

    Boston, Massachusetts, 02118, United States

  • Carilion Clinic

    RECRUITING

    Roanoke, Virginia, 24014, United States

  • Christiana Care

    RECRUITING

    Newark, Delaware, 19718, United States

  • Emory University School of Medicine

    RECRUITING

    Atlanta, Georgia, 30308, United States

  • Icahn School of Medicine at Mount Sinai

    RECRUITING

    New York, New York, 10029, United States

  • Intermountain Health

    RECRUITING

    Murray, Utah, 84107, United States

  • Lifespan

    RECRUITING

    Providence, Rhode Island, 02903, United States

  • Loyola University Chicago

    RECRUITING

    Maywood, Illinois, 60153, United States

  • Main Line Healh

    RECRUITING

    Wynnewood, Pennsylvania, 19096, United States

  • MaineHealth

    RECRUITING

    Portland, Maine, 04102, United States

  • MedStar Health Research Institute

    RECRUITING

    Washington D.C., District of Columbia, 20010, United States

  • Medical College of Wisconsin

    RECRUITING

    Milwaukee, Wisconsin, 53226, United States

  • Medical University of South Carolina

    RECRUITING

    Charleston, South Carolina, 29425, United States

  • NYU Langone Health - Tisch Hospital

    RECRUITING

    New York, New York, 10016, United States

  • Oregon Health & Science University

    RECRUITING

    Portland, Oregon, 97239, United States

  • Promedica

    RECRUITING

    Toledo, Ohio, 43606, United States

  • Rutgers New Jersey Medical School

    RECRUITING

    Newark, New Jersey, 07103, United States

  • Scripps Memorial Hospital, La Jolla

    RECRUITING

    San Diego, California, 92121, United States

  • Sentara Health Research Center

    RECRUITING

    Norfolk, Virginia, 23507, United States

  • Southern Illinois University School of Medicine

    RECRUITING

    Springfield, Illinois, 62781, United States

  • Stanford Medicine

    RECRUITING

    Palo Alto, California, 94304, United States

  • The Lundquist Institute

    RECRUITING

    Torrance, California, 90502, United States

  • The University of Alabama At Birmingham

    RECRUITING

    Birmingham, Alabama, 35233, United States

  • The University of Texas Health Science Center at Houston

    RECRUITING

    Houston, Texas, 77030, United States

  • Thomas Jefferson University

    RECRUITING

    Philadelphia, Pennsylvania, 19107, United States

  • Trinity Health - Ann Arbor Hospital

    RECRUITING

    Ypsilanti, Michigan, 48197, United States

  • UC Davis Health

    RECRUITING

    Sacramento, California, 95817, United States

  • University of Chicago Medical Center

    RECRUITING

    Chicago, Illinois, 60637, United States

  • University of Iowa

    RECRUITING

    Iowa City, Iowa, 52242, United States

  • University of Michigan

    RECRUITING

    Ann Arbor, Michigan, 48109, United States

  • University of New Mexico Health Sciences Center

    RECRUITING

    Albuquerque, New Mexico, 87131, United States

  • University of Pennsylvania

    RECRUITING

    Philadelphia, Pennsylvania, 19104, United States

  • University of Pittsburgh Medical Center

    RECRUITING

    Pittsburgh, Pennsylvania, 15232, United States

  • University of South Florida/ Tampa General Hospital

    RECRUITING

    Tampa, Florida, 33606, United States

  • University of Utah Health

    RECRUITING

    Salt Lake City, Utah, 84108, United States

  • Washington University in St. Louis

    RECRUITING

    St Louis, Missouri, 63110, United States

  • Weill Cornell Medicine

    RECRUITING

    New York, New York, 10065, United States

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