New Clot-Busting device could change how we treat dangerous lung clots

NCT ID NCT06041594

Recruiting now Disease control Sponsor: Innova Vascular, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 17, 2026 · Updated 2 times

Summary

This study tests a new device called the Laguna Thrombectomy System to remove blood clots from the lungs in people with pulmonary embolism. About 107 adults with moderate to severe clots will be treated, and doctors will check for safety and effectiveness within 48 hours. The goal is to see if the device can quickly clear the blockage without causing major bleeding or other serious problems.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Laguna Thrombectomy System (a device to remove blood clots from the lungs)
What this could lead to: If successful, this device could offer a new, less invasive way to quickly remove dangerous blood clots from the lungs, potentially reducing complications and improving recovery for people with pulmonary embolism.
What could go wrong: This is an early-stage study with only 107 participants, so results may not apply to everyone. There are risks of bleeding, heart or lung injury, and the device may not work better than existing treatments.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

pulmonary embolism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY EMBOLISM

Contacts and locations

Locations

AdventHealth Tampa
COMPLETED

Tampa, Florida, 33613, United States
Albany Medical Center
COMPLETED

Albany, New York, 12210, United States
Ankara Bilkent City Hospital
COMPLETED

Ankara, Turkey (Türkiye)
Ankara Etlik City Hospital
COMPLETED

Ankara, Turkey (Türkiye)
Dokuz Eylul University Research and Application Hospital
COMPLETED

Izmir, Turkey (Türkiye)
George Washington University
RECRUITING

Washington D.C., District of Columbia, 20037, United States
Grandview Medical Center
RECRUITING

Birmingham, Alabama, 35243, United States
Hacettepe University Hospital
COMPLETED

Ankara, Turkey (Türkiye)
Manatee Memorial Hospital
RECRUITING

Bradenton, Florida, 34209, United States
Memorial Care Long Beach Medical Center
RECRUITING

Long Beach, California, 90806, United States
Mission Hospital Regional Medical Center
RECRUITING

Mission Viejo, California, 92691, United States
OhioHealth Research Institute
RECRUITING

Columbus, Ohio, 43214, United States
Physicians Regional Medical Center
RECRUITING

Naples, Florida, 34119, United States
Rush University Medical Center
COMPLETED

Chicago, Illinois, 60612, United States
Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital
COMPLETED

Istanbul, Turkey (Türkiye)
St. Joseph Hospital of Orange
RECRUITING

Orange, California, 92868, United States
Turkey Creek Medical Center
RECRUITING

Knoxville, Tennessee, 37934, United States
University of Arizona
RECRUITING

Tucson, Arizona, 85724, United States
University of California Irvine
RECRUITING

Irvine, California, 92697, United States
University of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
University of Texas Southwestern
RECRUITING

Dallas, Texas, 75390, United States

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