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New clot-busting shot could save lives in dangerous lung condition

NCT ID NCT06362746

Recruiting now Disease control Sponsor: Supergene, LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a single injection of a clot-dissolving drug (staphylokinase) in 486 adults with intermediate high-risk pulmonary embolism—a serious blood clot in the lungs. The goal is to see if it prevents death, heart collapse, or another clot compared to a placebo. Participants must have a confirmed clot and signs of heart strain but stable blood pressure.

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Conditions

The condition(s) this trial relates to.

pulmonary embolism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY EMBOLISM

Contacts and locations

Locations

  • Asinovskaya District Hospital

    COMPLETED

    Asino, Tomsk Oblast, 636840, Russia

  • Belgorod Regional Clinical Hospital of St. Joseph

    RECRUITING

    Belgorod, 308007, Russia

  • Center of Neurology and Cardiology

    RECRUITING

    Kirov, 610035, Russia

  • City Clinical Hospital of Emergency medicine №25

    RECRUITING

    Volgograd, 400138, Russia

  • City Clinical Hospital №4

    WITHDRAWN

    Perm, 614107, Russia

  • City Hospital No. 15

    RECRUITING

    Saint Petersburg, 198205, Russia

  • City Hospital No. 26

    RECRUITING

    Saint Petersburg, 196247, Russia

  • F.I. Inozemtsev City Clinical Hospital

    RECRUITING

    Moscow, 105187, Russia

  • G.A. Zakharyin Clinical hospital №6

    RECRUITING

    Penza, 440071, Russia

  • Kuzbass Cardiology center

    RECRUITING

    Kemerovo, 650002, Russia

  • Lipetsk City Hospital No. 4 "Lipetsk-Med"

    RECRUITING

    Lipetsk, 398006, Russia

  • Moscow Multidisciplinary Clinical Center "Kommunarka"

    RECRUITING

    Moscow, 108814, Russia

  • N.A. Semashko Nizhny Novgorod Regional Clinical Hospital

    RECRUITING

    Nizhny Novgorod, 603093, Russia

  • N.N. Burdenko Penza Regional Clinical hospital

    WITHDRAWN

    Penza, 440026, Russia

  • RZD Medicine hospital

    RECRUITING

    Barnaul, Altayskiy Kray, 656038, Russia

  • Regional Clinical Hospital №2

    RECRUITING

    Krasnodar, 350012, Russia

  • S.P. Botkin City Clinical Hospital

    RECRUITING

    Moscow, Russia

  • S.S. Yudin City Clinical Hospital

    RECRUITING

    Moscow, 115446, Russia

  • Tomsk regional cilinical hospital

    RECRUITING

    Tomsk, 634063, Russia

  • Tver Regional Clinical Hospital

    RECRUITING

    Tver', 170036, Russia

  • Ufa Emergency City Hospital

    RECRUITING

    Ufa, 450092, Russia

  • V.F. Dolgopolov Vyselki Central District Hospital

    RECRUITING

    Vyselki, Krasnodarskiy Kray, 353100, Russia

  • V.M. Buyanov City Clinical Hospital

    RECRUITING

    Moscow, 115516, Russia

  • V.P. Polyakov Samara Regional Clinical Cardiology Dispensary

    RECRUITING

    Samara, 443070, Russia

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