Nerve rerouting surgery could stop phantom limb pain

NCT ID NCT06719245

Recruiting now Symptom relief Sponsor: Leiden University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests a surgical technique called targeted muscle reinnervation (TMR) to prevent phantom limb pain and stump pain after a leg amputation. About 200 adults having a leg amputation due to blood vessel disease will be randomly assigned to receive either TMR or standard nerve cutting. Participants will report their pain levels and quality of life over a year to see if TMR offers better pain control.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Targeted Muscle Reinnervation (TMR) surgical procedure
What this could lead to: If successful, TMR could become a standard surgical technique to prevent chronic pain after leg amputation, improving daily life for many patients.
What could go wrong: This is a relatively early-stage trial with 203 participants, and the sham-controlled design means some patients may not benefit. TMR is a complex surgery and may carry risks like infection or nerve damage.

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Conditions

The condition(s) this trial relates to.

neuroma peripheral vascular disease Phantom Limb

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AMPUTATION, SURGICAL NEUROMA AMPUTATION PHANTOM LIMB PAIN SURGERY

Contacts and locations

Locations

Alrijne Zorggroep
NOT_YET_RECRUITING

Leiderdorp, South Holland, 2353 GA, Netherlands
Amsterdam University Medical Center
NOT_YET_RECRUITING

Amsterdam, North Holland, 1105 AZ, Netherlands
Erasmus Medical Center
NOT_YET_RECRUITING

Rotterdam, South Holland, 3015 GD, Netherlands
Haaglanden Medisch Centrum
NOT_YET_RECRUITING

The Hague, South Holland, 2512 VA, Netherlands
Isala Zwolle
NOT_YET_RECRUITING

Zwolle, Overijssel, 8025 AB, Netherlands
Leiden University Medical Center
RECRUITING

Leiden, South Holland, 2333 ZA, Netherlands
University Medical Center Utrecht
NOT_YET_RECRUITING

Utrecht, Utrecht, 3584 CX, Netherlands

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