ARDS

This large Phase 3 trial is testing whether tiny particles released from bone marrow stem cells (called ExoFlo) can help hospitalized patients with severe Acute Respiratory Distress Syndrome (ARDS). The study will compare the treatment against a placebo in 970 patients to see if …

This study is testing whether a new drug called vilobelimab can help adults hospitalized with a severe lung condition called Acute Respiratory Distress Syndrome (ARDS). About 200 participants will be randomly assigned to receive either the new drug or a placebo, while all continu…

This study is testing whether adding the drug bevacizumab to standard hospital care helps adults with severe lung failure (ARDS). About 200 hospitalized patients will be randomly assigned to receive either the drug or a placebo, without doctors or patients knowing which one. The …

This study is testing whether using higher air pressure through a breathing mask helps people with severe pneumonia or ARDS avoid needing a breathing tube inserted down their throat. It will compare high pressure to standard low pressure in over 700 hospitalized patients. The mai…

This study is testing if a special blood filter called the HA380 can help critically ill patients who need machines to support their kidneys or lungs. The filter aims to remove harmful inflammation from the blood, which might help patients get off life support faster and spend le…

This study is testing a specific breathing technique, called a lung volume optimization maneuver, for children in two critical situations. For kids recovering from heart surgery, it aims to see if the technique improves heart function and lung mechanics, potentially shortening th…

This study is testing three different new drugs to see if they can help adults hospitalized with Acute Respiratory Distress Syndrome (ARDS), a severe and often deadly form of lung failure. About 600 participants will receive either one of the new treatments or a placebo, in addit…

This study is testing whether customizing ventilator settings based on detailed measurements of a patient's lung function can help more people survive severe lung failure (ARDS). It will compare this personalized approach to standard ventilator care in 740 critically ill patients…

This study is testing whether a new drug called paridiprubart can help hospitalized adults with Acute Respiratory Distress Syndrome (ARDS), a severe and life-threatening form of lung failure. About 200 participants will be randomly assigned to receive either the new drug or a pla…

This study is testing which feeding tube method works better for patients with severe lung failure (ARDS) who are on a ventilator and lying face down. It will compare feeding directly into the stomach versus feeding past the stomach into the small intestine. The goal is to see wh…

This study aims to check how well different medical devices measure a patient's blood flow and fluid needs while they are on a special life support machine called ECMO. Researchers will test 30 adult patients in intensive care who are on ECMO for severe lung failure. They will co…

This study aims to better understand ARDS, pneumonia, and sepsis by observing 4,000 hospitalized adults with these serious conditions. Researchers will collect health data, questionnaires, and samples like blood and urine from participants during and after their hospital stay. Th…

This study aims to check if common hospital devices that monitor heart function and blood flow give accurate readings for patients on a life support machine called VA ECMO. Researchers will test 30 adult patients on this machine by comparing measurements from different devices du…

This study aims to understand why some patients with severe lung failure (ARDS) develop additional infections while in the hospital. Researchers will look back at the medical records of 200 patients to see if their immune system status when they were admitted is linked to these c…

This study aims to understand how two different types of ARDS (Acute Respiratory Distress Syndrome) affect how the lungs use oxygen when different pressure levels are set on a breathing machine. Researchers will observe 50 sedated patients on ventilators in France, using a specia…

This study aims to understand if the amount of time a patient has only one lung breathing during chest surgery affects their risk of developing lung complications afterward, like pneumonia or severe breathing trouble. Researchers will observe 134 adults having this type of surger…

This study looks at past medical records to understand how well and how safely a special therapy works for ICU patients with severe breathing failure. The therapy, called low-flow ECCO2R, helps remove carbon dioxide from a patient's blood. Researchers will review data from about …

This study aims to understand the biology of life-threatening conditions like sepsis and ARDS by observing 1,000 critically ill patients in the ICU. Researchers will collect blood and fluid samples to identify early biological signs that could lead to faster diagnosis and better …