ARDS

This study tests a drug called bevacizumab in hospitalized adults with acute respiratory distress syndrome (ARDS), a severe lung condition. About 200 participants will receive either the drug or a placebo to see if it improves survival and oxygen levels. The goal is to find a saf…

This study tests several experimental treatments for adults hospitalized with acute respiratory distress syndrome (ARDS), a severe lung condition. About 600 participants will receive either a placebo or an active drug to see if the treatments improve survival and are safe. The go…

This Phase 2 trial tests a drug called paridiprubart in hospitalized adults with moderate to severe acute respiratory distress syndrome (ARDS), a serious lung condition. About 200 participants will receive either the drug or a placebo as a single IV dose. The main goal is to see …

This study tests a medicine called vilobelimab in adults hospitalized with moderate to severe acute respiratory distress syndrome (ARDS), a life-threatening lung condition. About 200 participants will receive either the drug or a placebo to see if it improves survival and is safe…

This study tests a blood filter called HA380 in 40 critically ill adults (ages 18-65) who need dialysis or ECMO due to severe infection, injury, or major surgery. The filter is added to their life-support circuit to remove inflammatory substances from the blood. Researchers want …

This phase 3 trial tests whether a single intravenous dose of ExoFlo, made from bone marrow stem cell vesicles, can lower the death rate in hospitalized adults with moderate-to-severe ARDS. About 970 participants will receive either ExoFlo or a placebo. The main goal is to see if…

This study looks at 40 adults with severe lung injury (ARDS) who need to lie on their stomachs while on a breathing machine. Researchers want to see if feeding through a tube into the stomach or deeper into the small intestine helps patients get better nutrition and recover faste…

This study tests whether setting a breathing machine based on each patient's lung mechanics can lower the chance of death within 60 days for people with acute respiratory distress syndrome (ARDS). It includes both COVID-19 and non-COVID-19 patients. The approach is compared to st…

This study looks at whether using higher pressure during noninvasive breathing support (a mask that helps you breathe) can help people with pneumonia or ARDS avoid needing a breathing tube. About 700 adults will be randomly assigned to receive either high or low pressure. The mai…

This study checks how well standard devices measure blood flow in patients on ECMO, a machine that adds oxygen to blood outside the body. About 30 adults on ECMO will have their blood flow measured using different methods, including ultrasound and a leg-raising test. The goal is …

This study checks how well standard devices measure blood flow in 30 adults on ECMO, a machine that pumps and oxygenates blood outside the body. The goal is to see if these monitors give accurate readings during this special situation. Results could help doctors better manage flu…

This study tests a computer program that gives doctors step-by-step advice on how to set breathing machines for children with acute respiratory distress syndrome (ARDS). The goal is to see if the tool can be used in multiple hospitals and if doctors follow its recommendations. Up…

This study tests whether a personalized lung volume optimization maneuver can improve heart and lung function in children on ventilators. It includes two groups: children recovering from heart surgery and those with severe respiratory failure. Researchers will adjust ventilator p…

This study is enrolling 4,000 adults in intensive care with ARDS, sepsis, or pneumonia. Researchers will collect blood, urine, and swab samples, plus track recovery for up to a year. The goal is to identify different patient subtypes and find clues that could lead to better treat…

This study looks back at medical records of about 59 ICU patients who used a low-flow carbon dioxide removal (ECCO2R) machine for breathing failure. The goal is to describe how the device was used and what happened to patients, including survival and side effects. It does not tes…

This study observes 134 adults having chest surgery to see if the time spent breathing with only one lung is linked to lung problems like pneumonia or ARDS. Researchers will track surgery details and check for complications within the first week after the procedure. The goal is t…

This study looks at how two different levels of breathing support (called PEEP) affect lung function in patients with a severe lung condition called ARDS. The researchers want to see if the response differs based on the patient's lung stiffness. They will use a special imaging te…

This study is observing 1,000 critically ill ICU patients to learn how their bodies respond to life-threatening infections and injuries. Researchers will collect blood and lung fluid samples to identify biological factors that could lead to earlier diagnosis and new treatments fo…