ARDS

This study tests whether setting a breathing machine based on each patient's lung stiffness and breathing effort can lower the chance of death within 60 days for people with acute respiratory distress syndrome (ARDS). About 740 adults with moderate to severe ARDS, including those…

This study tests a drug called bevacizumab in hospitalized adults with acute respiratory distress syndrome (ARDS), a severe lung condition. About 200 participants will receive either the drug or a placebo to see if it improves survival and safety. The main goal is to measure how …

This study tests a blood filter called HA380 in 40 very ill adults (ages 18–65) who are on dialysis or a heart-lung machine (ECMO) due to severe infection, injury, or major surgery. The filter aims to remove inflammatory substances from the blood, potentially reducing time on lif…

This study looks at two ways of feeding patients with severe lung injury (ARDS) who are on a ventilator and lying on their stomach. About 40 adults will be randomly assigned to get nutrition through a tube in the stomach or one in the small intestine. The goal is to see which met…

This study tests a drug called vilobelimab in adults hospitalized with severe lung failure (ARDS). About 200 participants will receive either the drug or a placebo. The main goal is to see if the drug reduces deaths within 28 days.

This study looks at whether using higher positive pressure during noninvasive ventilation (a mask that helps you breathe) can help people with pneumonia or acute respiratory distress syndrome (ARDS) avoid needing a breathing tube. About 700 adults who are awake and need mask brea…

This study tests an experimental drug called paridiprubart in adults hospitalized with moderate to severe acute respiratory distress syndrome (ARDS), a serious lung condition. About 200 participants will receive either the drug or a placebo to see if it improves survival and safe…

This study tests several experimental treatments for adults hospitalized with acute respiratory distress syndrome (ARDS), a severe lung condition. About 600 participants will receive either a placebo or one of the active drugs to see if they improve survival and recovery. The goa…

This study tests a treatment called ExoFlo, made from stem cell particles, for people hospitalized with moderate-to-severe acute respiratory distress syndrome (ARDS), a serious lung condition. About 970 adults aged 18-75 will receive either ExoFlo or a placebo through an IV. The …

This study checks if standard heart and blood flow monitors work correctly in patients on ECMO, a machine that adds oxygen to blood outside the body. Researchers will compare three monitoring methods in 30 adults on ECMO for severe lung failure. The goal is to improve how doctors…

This study checks how accurate standard circulation monitors are for patients on ECMO, a machine that pumps and oxygenates blood outside the body. Researchers will compare three different monitoring methods in 30 adults aged 18–75 who are on ECMO. The goal is to improve how docto…

This study looks back at medical records of about 60 ICU patients who used a low-flow ECCO2R machine to help remove carbon dioxide from their blood when their lungs were failing. The goal is to describe how the therapy was used and what outcomes patients had, including side effec…

This study looks back at medical records of 200 people with severe lung failure (ARDS) to see how their immune system affects the chance of getting extra infections like herpes or cytomegalovirus. Researchers will measure immune cells and virus levels in blood and lung fluid. No …

This study is observing 4,000 adults in intensive care with ARDS, sepsis, or pneumonia to identify different types of these illnesses. Researchers will collect medical information and samples to build a biobank for future studies. The goal is to improve understanding of risk fact…

This study tests a computer program that helps doctors make better decisions about breathing machine settings for children with severe lung injury (ARDS). The tool is based on the best available evidence and aims to reduce differences in care across hospitals. Up to 180 children …

This study tests a personalized breathing maneuver in children on ventilators—either after heart surgery or with severe lung failure. The goal is to see if adjusting the breathing machine settings can improve heart and lung function, reduce time on the ventilator, and lower the n…

This study looks at how changing the pressure in a ventilator affects lung function in two groups of patients with severe lung injury (ARDS). Researchers will use a special imaging technique to see how air and blood flow match up in the lungs. The goal is to find the best ventila…

This study watches 134 adults having chest surgery to see if the time one lung is used for breathing affects lung problems like pneumonia or ARDS. It does not test a new treatment but aims to find a safer surgery window. Results may help doctors plan better to reduce risks.

This study is observing 1,000 adults in the intensive care unit (ICU) to learn more about why some people get very sick from infections or injuries. Researchers will collect blood samples and health data to find early signs that could help diagnose serious conditions like sepsis …