Could a gentle brain zap ease MS fatigue?

NCT ID NCT07438964

Recruiting now Symptom relief Sponsor: Charite University, Berlin, Germany Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a mild electrical current applied to the front of the brain for 20 minutes a day over five days can reduce central fatigue in people with relapsing-remitting multiple sclerosis. Researchers will use brain scans and blood tests to see if the stimulation changes inflammation and reward-related brain activity. The trial includes 84 participants and will follow up for four weeks after treatment.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: transcranial direct current stimulation (tDCS)
What this could lead to: If it works, this could point toward a non-drug treatment for central fatigue in multiple sclerosis.
What could go wrong: This is an early, small study (84 people) testing a short-term intervention. The effect may be small or not last, and fatigue is complex with many causes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Fatigue multiple sclerosis relapsing-remitting multiple sclerosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FATIGUE IN MULTIPLE SCLEROSIS MULTIPLE SCLEROSIS

Contacts and locations

Locations

Charité Campus Mitte
RECRUITING

Berlin, State of Berlin, 10117, Germany

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