Charite University, Berlin, Germany

This study tests whether newer, targeted immunotherapy drugs (like inotuzumab and blinatumomab) can replace harsh chemotherapy for children whose B-cell acute lymphoblastic leukemia has returned. About 750 children and teens will receive these less toxic treatments to see if they…

This study looks at how artificial sweeteners (saccharin, sucralose) and a natural one (erythritol) affect heart disease risk factors in 80 adults with prediabetes. Participants will be randomly assigned to consume one sweetener or water for two weeks. Researchers will measure ch…

This study looks at whether a special breathing maneuver during heart surgery can improve heart and lung function in children with congenital heart disease. About 80 children will be randomly assigned to receive either the maneuver or standard care. The goal is to see if this app…

This study tests whether a conversation with an AI (like ChatGPT) can help gynecologists better understand the true benefits and risks of ovarian cancer screening. Many doctors overestimate how helpful screening is for average-risk women. The study will involve 350 gynecologists …

This study will follow about 12,750 adults and children who have had a stroke (either from a clot or bleeding in the brain). Researchers will collect information on their care from the moment they arrive at the hospital through recovery and long-term follow-up. The goal is to lea…