Charite University, Berlin, Germany

This study tests a new treatment called CAR-T cell therapy against a standard drug, rituximab, in people with active rheumatoid arthritis that hasn't improved with other treatments. The goal is to see if CAR-T cells are safe and can reduce harmful antibodies linked to the disease…

This study tests a digital decision-support tool to help doctors follow guidelines that prevent postoperative delirium (sudden confusion after surgery) in patients aged 70 and older. About 845 participants will be monitored for up to 5 days after elective surgery to see if the to…

This study compares standard cognitive behavioral therapy (CBT) alone to CBT plus a group program called Kiesler Circle Training (KCT) that focuses on improving interpersonal skills. Researchers want to see if adding KCT helps people with depression or anxiety disorders interact …

This study tests whether vericiguat, a drug already approved for heart failure, can improve physical function and reduce fatigue in people aged 18-50 with post-COVID syndrome. About 104 participants will receive either vericiguat or a placebo for 10 weeks. The goal is to see if t…

This study tests a special body suit that uses mild electric pulses to stimulate muscles during exercise on the International Space Station. Eight astronauts will wear the suit during their workouts to see if it helps prevent muscle loss and stiffness in microgravity. Researchers…

This study looks at over 900,000 hospital patient records to find out which medications might make older adults more likely to fall. Researchers are checking a German list of risky drugs (PRISCUS) and looking for other medicines that could be added. The goal is to help doctors pr…

This study looks at 30 people with Parkinson's disease who are scheduled for deep brain stimulation (DBS). Researchers will test brain scans, thinking tests, and other measures before surgery and at 3, 12, and 60 months after to see which factors predict memory or thinking proble…