Charite University, Berlin, Germany

This study tests whether a 20-day fasting schedule before hip replacement surgery can reduce complications like infections. 130 adults will either follow the fasting plan or receive standard care. Researchers will measure changes in gut bacteria and immune markers to see if fasti…

This study looks at a blood-filtering procedure called immunoadsorption (IA) in 50 people with ME/CFS or Post-COVID syndrome who have certain autoantibodies. The goal is to see if removing these antibodies improves symptoms like severe fatigue and brain fog. Researchers will trac…

This study tests whether a machine that keeps donated livers working outside the body can help doctors safely use livers that were previously considered too risky for transplant. About 186 adults on the liver transplant waiting list will be randomly assigned to either receive a s…

This study tests whether gentle brain stimulation (tVNS or CLAM-tACS) during mindfulness exercises can help people recovering from alcohol dependence stay sober. 140 detoxified patients will take part in a mindfulness-based relapse prevention program, with some receiving stimulat…

This study tests whether adding the drug bortezomib to standard chemotherapy helps more children with high-risk relapsed acute lymphoblastic leukemia (ALL) achieve remission. About 250 children under 18 with a first relapse of ALL will be randomly assigned to receive either stand…

This study tests a 12-week digital exercise program for people who had ACL knee surgery. The program uses sensors to help correct how the knee moves during walking, with the goal of reducing joint inflammation and preventing osteoarthritis. Researchers will enroll 60 adults aged …

This study tests a new type of heart valve made from a patient's own tissue to treat a leaky pulmonary valve. Seven adults will receive the valve to see if it is safe and works well in the short term. The valve is designed to grow with the patient, potentially reducing the need f…

This study tests whether a dermatologist's physical exam is better than a patient questionnaire at spotting psoriatic arthritis (PsA) in people with psoriasis. About 500 adults with psoriasis will be checked by both methods, then referred to a rheumatologist for a final diagnosis…

This study looks at using a computer algorithm to quickly diagnose sepsis and septic shock from routine hospital data. Researchers will analyze information from 10,000 ICU patients to see if the algorithm can speed up diagnosis and improve patient outcomes. The goal is to help do…

This study tests a structured care program to prevent postoperative delirium (sudden confusion) in patients aged 70 and older undergoing surgery. Over 18,000 participants will receive evidence-based prevention measures, with electronic tracking to ensure consistency. Additional s…

This study tests whether a two-day psychoeducational training can help prevent burnout among medical and non-medical workers in Ukraine during wartime. Eighty participants will receive the training and be assessed before, after, and at follow-up. The main goal is to see if the pr…

This study compares two approaches for heart attack survivors with weak hearts: taking modern medications alone versus getting a defibrillator implant plus medications. The goal is to see if medication alone is as good at preventing sudden cardiac death. About 3,600 participants …

This study tests whether adding alcohol-related smells to virtual reality (VR) scenes is feasible and tolerable for people with alcohol dependence. Twenty participants will experience VR cue exposure with scents like beer or wine, and researchers will measure craving, side effect…

This study is testing a self-guided internet program called Velibra for people with panic disorder, social anxiety, or generalized anxiety disorder who are on a waitlist for treatment. The program uses cognitive behavioral therapy techniques over six weeks. Researchers want to se…

This study explores whether a yoga-based group program is practical and helpful for outpatients with schizophrenia. Sixty participants will be randomly assigned to yoga, strength training, or standard care. Researchers will measure stress, symptoms, and well-being over 12 weeks a…

This study tests whether a smartphone app called Kiso Mind is acceptable and helpful for people with schizophrenia or schizoaffective disorder. Sixty participants will either use the app plus their usual treatment, or just usual treatment alone, for 12 weeks. Researchers will mea…

This study tests whether a mild electrical current applied to the front of the brain for 20 minutes a day over five days can reduce central fatigue in people with relapsing-remitting multiple sclerosis. Researchers will use brain scans and blood tests to see if the stimulation ch…

This study tests whether dynamic light therapy can restore natural sleep-wake cycles in intensive care patients suffering from delirium. Forty adults in the ICU will receive either a special light algorithm or standard hospital lighting. Researchers will measure changes in melato…

This study tests whether an oxytocin nasal spray, given before mindfulness-based group therapy, can reduce negative symptoms in people with schizophrenia. Negative symptoms include lack of motivation, social withdrawal, and reduced emotional expression. The trial will compare two…

This study tests a program to improve palliative care in intensive care units (ICUs). The program includes remote consultations with palliative care experts, training for ICU staff, and checklists to identify patients who need extra support. Researchers will track 2040 patients t…

This study compares two types of acupuncture—one using mild electrical currents and one using manual massage—for treating bladder dysfunction in women with multiple sclerosis. 150 women aged 18-60 will be randomly assigned to one of the two treatments plus routine care. The goal …

This study follows 200 healthy transgender people for five years after they start hormone replacement therapy. Researchers will track changes in gut bacteria, blood markers, and heart risk factors to understand how sex hormones influence the gut-heart connection. The goal is to l…

This huge study of 100,000 adults compares two common anesthetics—propofol and sevoflurane—to see which one lowers the risk of postoperative delirium (sudden confusion after surgery). Researchers will track patients for 5 days after elective surgery. The goal is to provide clear …

This study will look at electronic health records from up to 1 million patients who had anesthesia or intensive care at Charité Hospital in Berlin since 2016. Researchers will use data science to find patterns linked to better or worse outcomes, such as survival and recovery. The…

This study tests whether a personalized lung volume optimization maneuver can improve heart and lung function in children on ventilators. It includes two groups: children recovering from heart surgery and those with severe respiratory failure. Researchers will adjust ventilator p…

This study is analyzing data from 26,000 intensive care patients to see if following certain quality care steps leads to better outcomes and lower costs. Researchers will look at things like patient health scores, hospital revenue, and costs per case. The goal is to find which ca…

This study explores whether a single dose of L-dopa, a drug used for Parkinson's, can improve motivation and motor function in people with major depression who have signs of low-grade inflammation. Researchers will compare L-dopa to a placebo in 165 participants (patients and hea…

This study follows 200 adults who have had or will have a procedure to fix a leaky or narrowed valve in the right side of the heart. Researchers track survival, unplanned hospital stays, and heart function using blood tests and ultrasound. The goal is to learn which treatments wo…

This study watches 500 people with cystic fibrosis who are already taking CFTR modulator medicines. Researchers measure sweat chloride, nasal electrical activity, and rectal tissue responses to see how well the drugs improve CFTR protein function. The goal is to better understand…

This study looks at how changes in preoperative care affect anxiety in 100 children with congenital heart disease who need surgery or catheterization. Researchers will measure stress levels using questionnaires and scales, and also get feedback from parents and care teams. The go…

This study looks at whether a single dose of estradiol (a hormone) can reduce the number of intrusive, unwanted memories that form after a traumatic event. Healthy female volunteers will watch a stressful film and then record any intrusive memories over the next four days. The go…

This study looks at why some patients who survive intensive care do not attend their follow-up appointments. Researchers will review medical records of 2,500 adults invited to a post-ICU clinic between 2021 and 2025. The goal is to find patterns and reasons for missed appointment…

This study is observing 2,500 adults with chronic diseases who receive inpatient Traditional, Complementary and Integrative Medicine (TCIM) at three German hospitals. The therapy combines approaches like hyperthermia, exercise, herbal medicine, and dietary changes. Researchers wi…

This study reviews data from 5,000 adults aged 18-100 who had surgery lasting at least an hour. The goal is to find out how often people experience brain fog (called postoperative cognitive dysfunction or POCD) after surgery. No new treatments are being tested—researchers are jus…

This study looks at brain activity in 25 people with dystonia who are getting deep brain stimulation (DBS). The goal is to find brain signals that can help doctors adjust the stimulation more quickly and personally. Participants will use a special pacemaker that records brain sig…

This study looks at how pregnant and non-pregnant people recover after being in the intensive care unit (ICU) for severe COVID-19. Researchers will check for problems with movement, thinking, and mental health 3 to 6 months after leaving the ICU. The goal is to understand the lon…

This study tests whether eating all meals within an 8-hour window (before 10 AM) for four weeks can improve how well older adults respond to seasonal flu and COVID-19 vaccines. Researchers will measure changes in immune cell activity and body composition in 24 healthy volunteers …

This study interviews 60 prostate cancer patients and their caregivers to learn about their experiences during and after radiotherapy. The goal is to understand their needs and wishes regarding prehabilitation — preparing for treatment. This is not a treatment trial, but a fact-f…

This study looks at how much protein cancer patients eat before, during, and after radiotherapy, and whether that affects their muscle mass and quality of life. Researchers will track 175 adults aged 45 and older undergoing radiation for various tumors. The goal is to understand …