POSTOPERATIVE DELIRIUM

This study tests whether electroacupuncture, a type of acupuncture with mild electric current, can prevent postoperative delirium (sudden confusion) in older adults having total knee replacement. About 1,460 people aged 65-90 will be randomly assigned to receive electroacupunctur…

This study tests whether a drug called esketamine can reduce confusion and memory problems in older adults after major non-cardiac surgery. Researchers will compare three different doses in 120 patients aged 65 to 90. The goal is to find the dose that best protects brain function…

This study tests whether giving flumazenil after hip replacement surgery can prevent confusion and memory problems. 150 adults having hip surgery under spinal anesthesia will receive either flumazenil or a placebo. Researchers will check thinking skills and delirium rates in the …

This study tests whether a sedative called remimazolam can lower the risk of postoperative delirium (sudden confusion) in people 65 and older having laparoscopic stomach cancer surgery. 170 participants will be randomly assigned to receive either remimazolam or a standard sedativ…

This study looks at whether giving older patients (60+) a paracetamol injection after non-cardiac surgery can lower their risk of postoperative delirium—a state of sudden confusion. About 1,092 participants will be randomly assigned to receive either paracetamol or a standard opi…

This study looks at whether taking creatine, a supplement often used for muscle strength, can help protect the brains of older adults having surgery. Surgery can sometimes cause confusion or memory problems. The researchers will give creatine to 80 older adults before and after s…

This study looks at whether giving ibuprofen during and after lung surgery (using one lung for breathing) can help keep the brain well-oxygenated and reduce confusion or memory loss afterward. About 54 adults aged 18–75 having keyhole lung surgery will be randomly assigned to rec…

This study looks at whether a blood sugar measurement taken before surgery can help predict if a patient will experience postoperative delirium—a state of confusion that can slow recovery. Researchers will review medical records from 15,000 adults who had non-brain, non-heart sur…

This study looks at whether measuring sugar use in a key memory part of the brain can help predict confusion (delirium) after surgery in older adults with type 2 diabetes. Researchers will scan the brains of 154 people before liver surgery and check for confusion afterward. The g…

This study looks at whether the way you sleep before heart surgery is connected to your risk of confusion (delirium) and kidney injury after the operation. Researchers will track 549 adults having planned heart surgery with a heart-lung machine. The goal is to better understand t…

This study will test whether using brain-wave (EEG) monitoring to guide pain medicine during surgery can help prevent delirium—sudden confusion—in older adults after the operation. Researchers plan to enroll 600 people aged 60 and older who are having non-cardiac, non-head/neck s…

This study will measure certain brain chemicals in 200 children aged 1-3 years before, during, and after hernia surgery. The goal is to see if these chemicals can predict which children might become confused or have learning problems later. Researchers will also compare two types…

This study looks at whether older adults with mild thinking or memory problems are more likely to become confused after planned hip replacement surgery. About 400 people aged 65 and older will take a short thinking test before surgery and be checked for confusion for three days a…

This study looks at whether a simple test can predict who will become confused after heart surgery. About 100 adults having planned heart surgery will take a memory and orientation test before their operation. Researchers will then track who develops delirium (sudden confusion) i…

This study looks at whether measuring the optic nerve sheath (the protective layer around the nerve at the back of the eye) using ultrasound can help predict delirium—sudden confusion or agitation—after heart surgery. Researchers will monitor 300 adults undergoing heart surgery a…