POSTOPERATIVE DELIRIUM

This study tests whether electroacupuncture, a type of acupuncture with mild electrical stimulation, can prevent postoperative delirium in adults aged 65-90 undergoing total knee replacement. Over 1,400 participants will receive either real or placebo acupuncture before surgery. …

This study looks at whether using a drug combination without opioids during anesthesia can lower the chance of confusion (delirium) after surgery in people 65 and older having gastrointestinal surgery. About 174 participants will be randomly assigned to receive either opioid-free…

This study tests whether taking creatine supplements before surgery can help protect thinking, memory, and attention in older adults. Creatine is widely used for muscle performance, but may also support brain health. Researchers will give creatine to 80 older adults scheduled for…

This study tests whether a drug called esketamine can help prevent confusion and memory problems that sometimes happen after surgery in older adults. The trial will involve 120 people aged 65 to 90 who are having major non-cardiac surgery. Researchers will compare three different…

This study looks at whether giving ibuprofen during and right after lung surgery can help keep the brain well-oxygenated and lower the risk of confusion or memory problems afterward. About 54 adults having a type of keyhole lung surgery will be split into two groups: one gets ibu…

This study tests whether remimazolam, a newer anesthetic, can reduce the risk of postoperative delirium (sudden confusion) in elderly patients undergoing laparoscopic stomach cancer surgery. Researchers will compare remimazolam to standard anesthesia in 170 patients aged 65 and o…

This study will test whether using EEG brain monitoring to adjust pain medicine during surgery can reduce the risk of delirium (sudden confusion) after surgery in adults aged 60 and older. Researchers plan to enroll 600 participants undergoing non-cardiac, non-head/neck surgery l…

This study tests whether giving flumazenil after hip replacement surgery can reverse the effects of the sedative remimazolam and improve thinking. 150 adults will receive either flumazenil or a placebo right after surgery. Researchers will check their memory and confusion levels …

This study will test whether giving paracetamol (a common painkiller) instead of a strong opioid (sufentanil) can reduce confusion and delirium in elderly patients after non-cardiac surgery. About 1,092 patients aged 60 and older will be randomly assigned to receive either parace…

This study looks at whether the way you sleep before heart surgery is connected to problems like confusion (delirium) or kidney damage after the operation. Researchers will track 549 adults having planned heart surgery with a heart-lung machine. The goal is to find patterns that …

This study will test a simple score to predict which patients may become confused (delirium) after planned heart surgery. About 100 adults will be checked before surgery using memory, orientation, and frailty tests. The goal is to identify high-risk patients early so doctors can …

This study looks at whether older adults with mild memory issues are more likely to become confused after planned hip replacement surgery. Researchers will test memory before surgery and watch for confusion in the first three days after. The goal is to see if a quick memory test …

This study will follow 154 older adults with type 2 diabetes who are scheduled for liver tumor surgery. Researchers will measure brain glucose metabolism using a PET scan before surgery and then check for delirium (sudden confusion) for a week after. The goal is to see if lower b…

This study looks at whether measuring the optic nerve sheath (the covering of the nerve at the back of the eye) using ultrasound can help predict delirium—sudden confusion or agitation—after heart surgery. Researchers will monitor 300 adults before and after their operation. The …

This study will measure certain brain proteins in 200 children aged 1-3 years undergoing hernia surgery. Researchers want to see if changes in these proteins can predict postoperative delirium and long-term thinking problems. They will also compare two common anesthetics, sevoflu…

This study looks at whether a simple blood sugar measurement, called the stress hyperglycemia ratio (SHR), can help predict which patients will develop delirium (sudden confusion) after surgery. Researchers will analyze medical records from 15,000 adults who had non-brain, non-he…