POSTOPERATIVE DELIRIUM

This study aims to see if a form of acupuncture with mild electrical stimulation can prevent post-surgery delirium—a sudden state of confusion—in older adults getting knee replacements. Researchers will compare the treatment to standard care across multiple hospitals with 1,460 p…

This study is testing whether taking creatine, a supplement often used by athletes, can help protect the brain in older adults having surgery. Surgery can sometimes cause temporary problems with memory, thinking, and attention. Researchers will give creatine to 80 older adults be…

This study aims to see if using a common intravenous pain medication (acetaminophen) is better than a stronger opioid (sufentanil) at preventing confusion and delirium in older patients after non-heart surgery. It will involve over 1,000 patients aged 60+ in intensive care units …

This study is testing if a new anesthesia drug called remimazolam can reduce confusion (postoperative delirium) in patients 65 and older after stomach cancer surgery. It will compare remimazolam against a standard anesthesia mix in 170 patients. The main goal is to see if the new…

This study aims to see if monitoring brain waves during surgery can help doctors better adjust pain medication to reduce confusion and delirium in older patients after their operation. Researchers will recruit 600 adults aged 60+ undergoing elective non-cardiac surgery lasting at…

This study tests whether giving a drug called flumazenil to reverse sedation after hip replacement surgery can help prevent confusion and thinking problems that sometimes occur after surgery. Researchers will compare flumazenil to a placebo in 150 patients to see if it improves c…

This study is testing if giving the common anti-inflammatory drug ibuprofen during and right after lung surgery can help protect the brain. Researchers want to see if it improves oxygen levels in the brain during the operation and reduces post-surgery confusion and memory problem…

This study aims to identify which patients are most at risk for developing confusion (called delirium) after elective heart surgery. Researchers will observe 100 adult patients to test how well a specific prediction score works. The goal is to better understand risk factors so do…

This study aims to find out if a special brain scan taken before surgery can predict which older patients with type 2 diabetes are most likely to experience confusion and delirium after an operation. Researchers will enroll 154 patients scheduled for liver tumor surgery and measu…

This study aims to find out if a pre-surgery blood sugar measurement, called the stress hyperglycemia ratio (SHR), can help predict which patients are most likely to develop confusion (delirium) after an operation. Researchers will look back at the medical records of 15,000 adult…

This study aims to see if a simple, non-invasive eye ultrasound can help predict which patients become confused after heart surgery. Researchers will measure the thickness of a nerve behind the eye in 300 patients before and after their operation. They will compare these measurem…

This study aims to understand if a brief memory test given before hip replacement surgery can help predict which older patients might experience sudden confusion after their operation. Researchers will observe about 400 patients aged 65 and older across several hospitals in the C…

This study aims to understand why some young children experience confusion or agitation after surgery and if it affects their long-term learning and memory. Researchers will measure specific chemicals in the blood of 200 children (ages 1-3) before and after a common hernia repair…