Could a common painkiller keep seniors Clear-Headed after surgery?
NCT ID NCT07235995
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study will test whether giving paracetamol (a common painkiller) instead of a strong opioid (sufentanil) can reduce confusion and delirium in elderly patients after non-cardiac surgery. About 1,092 patients aged 60 and older will be randomly assigned to receive either paracetamol or sufentanil for pain control in the ICU. The main goal is to see if paracetamol leads to fewer cases of postoperative delirium.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
paracetamol (acetaminophen) and mannitol injection
What this could lead to
If it works, this could offer a safer painkiller option for older patients after surgery, reducing their risk of confusion and other side effects.
What could go wrong
This is a phase 4 trial, so the drugs are already approved, but it is still possible that paracetamol does not reduce delirium better than the standard opioid. The study has not started yet, so results are pending.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Xiangya hospital
Changsha, Hunan, 410000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••