POSTOPERATIVE DELIRIUM

This study tests whether a sleep medication called daridorexant can prevent delirium (sudden confusion) after heart surgery. About 80 adults aged 60 and older having valve or bypass surgery will take either the drug or a placebo for three nights after surgery. Researchers will ch…

This study tests whether doing simple brain exercises at home for a few weeks before heart surgery can help prevent confusion (delirium) and memory problems that often occur after the operation. The researchers will enroll 100 adults scheduled for elective heart surgery. Half wil…

This study tests whether relaxing before heart surgery using virtual reality and binaural beats (special sounds) can lower stress and prevent postoperative confusion or memory problems. About 125 adults having elective heart surgery will be randomly assigned to receive the relaxa…

This study compares two sedative drugs, dexmedetomidine and midazolam, to see which one better prevents confusion (delirium) after heart bypass surgery. About 60 adults having elective coronary artery bypass grafting will take part. The goal is to find out which medication leads …

This study tests a digital sleep improvement program (a mobile app and a wrist tracker) in 50 older adults (65+) who are having hip or knee replacement surgery. The goal is to see if better sleep can reduce confusion or memory problems after surgery. Participants must have mild i…

This study looks at whether a score based on routine blood tests (called the Naples Prognostic Score) can predict postoperative delirium—sudden confusion—in older adults after hip fracture surgery. Researchers will enroll 168 patients aged 60 and older and check for delirium dail…

This study follows 1,500 adults having planned heart surgery to learn why some become confused or delirious afterward and how that affects their recovery. Researchers will track factors before surgery and check patients' mental status after. No new treatments are tested; the goal…

This study watches 270 older adults (65+) having non-heart surgery to see how often they get confused or delirious afterward. Researchers will track things like age, health, and frailty to find out what raises the risk. The goal is to better understand and predict this common com…

This study looks at whether certain proteins in the blood can help predict if older adults with diabetes will experience confusion (delirium) after surgery. Researchers will measure these proteins before surgery in 180 participants aged 65 and older. The goal is to find early war…

This study looks at 500 adults having heart surgery to see if keeping blood pressure within a personalized safe range for the brain reduces confusion, stroke, or memory loss after surgery. Researchers use special monitors to track brain blood flow and adjust anesthesia accordingl…

This study looks at whether feeling distressed before surgery raises the risk of confusion (delirium), pain, and longer hospital stays in adults 65 and older having major hip or knee surgery. Researchers will measure distress before surgery and track recovery afterward. The goal …

This study watches 100 adults aged 60 and older during major non-cardiac surgery to learn how to set the best blood pressure for brain health. Researchers use non-invasive forehead monitors to track brain activity and oxygen levels. The goal is to see if these monitors can help t…

This study is looking at whether certain markers in a child's blood before surgery can predict if they will become confused or agitated after waking up from anesthesia. The study will include 140 children, ages 2 to 12, who are having circumcision. Researchers will measure inflam…