Could more caffeine help tiniest babies breathe easier?

NCT ID NCT07216365

Recruiting now Disease control Sponsor: University of Rochester Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 30, 2026 · Updated 2 times

Summary

This study tests whether a higher dose of caffeine citrate can improve breathing and reduce complications in extremely premature infants (born before 28 weeks). Forty babies will be randomly assigned to receive either a high or standard dose of caffeine, starting at one week old. Researchers will monitor oxygen levels, need for breathing support, and side effects to find the safest, most effective dose.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: caffeine citrate
What this could lead to: If successful, this study could establish a safer, more effective caffeine dose to help extremely premature babies breathe better and reduce serious complications like lung disease.
What could go wrong: This is a small, early-phase trial with only 40 infants, so results may not apply to all preemies. Higher caffeine doses could also cause side effects like rapid heart rate or high blood pressure.

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Conditions

The condition(s) this trial relates to.

infantile apnea

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFANTS NEONATAL APNEA

Contacts and locations

Locations

University of Rochester Medical Center
RECRUITING

Rochester, New York, 14642, United States

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