Major study to decide: transplant or medication for kids with sickle cell?
NCT ID NCT06941389
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This large study will follow 480 children with sickle cell disease to compare two treatment approaches: a stem cell transplant from a matched family donor versus standard disease-modifying therapies. The goal is to see which option leads to better quality of life and thinking skills over three years. By tracking both groups, researchers hope to provide clear information to help families and doctors make informed treatment decisions.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
matched related donor hematopoietic stem cell transplantation (MRD HCT) and non-transplant disease-modifying therapies (NT-DMT)
What this could lead to
If successful, this study could help families and doctors choose the best treatment for children with sickle cell disease by comparing long-term quality of life and thinking abilities.
What could go wrong
This is an observational study, not a controlled trial, so results may be influenced by factors like patient choice. It will take years to complete and may not provide clear answers for every child.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Alberta Children's Hospital (MRD-HCT)
RECRUITINGCalgary, Alberta, T3B6A8, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Alberta Children's Hospital (NT-DMT)
NOT_YET_RECRUITINGCalgary, Alberta, T3B 6A8, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Atrium Health (MRD-HCT)
RECRUITINGCharlotte, North Carolina, 28203, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Boston Children's Hospital (MRD-HCT)
RECRUITINGBoston, Massachusetts, 02115, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Boston Children's Hospital (NT-DMT)
NOT_YET_RECRUITINGBoston, Massachusetts, 02115, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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British Columbia Children's Hosptial (MRD HCT)
NOT_YET_RECRUITINGVancouver, British Columbia, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Healthcare of Atlanta (MRD-HCT)
RECRUITINGAtlanta, Georgia, 30329, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital at Montefiore (MRD HCT)
NOT_YET_RECRUITINGThe Bronx, New York, 10467, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Children's Hospital at Montefiore (NT-DMT)
RECRUITINGThe Bronx, New York, 10467, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's Hospital of Philadelphia (MRD-HCT)
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Children's National Hospital (MRD-HCT)
RECRUITINGWashington D.C., District of Columbia, 20010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Children's of Alabama (MRD-HCT)
RECRUITINGBirmingham, Alabama, 35294, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Children's of Alabama (NT-DMT)
NOT_YET_RECRUITINGBirmingham, Alabama, 35294, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Cohen's Children Hospital (NT-DMT)
NOT_YET_RECRUITINGQueens, New York, 11040, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Columbia Presbytarian (NT-DMT)
NOT_YET_RECRUITINGNew York, New York, 10032, United States
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Comer Children's Hospital (MRD-HCT)
RECRUITINGChicago, Illinois, 60637, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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HSC Winnipeg Children's Hospital/University of Manitoba (MRD-HCT)
RECRUITINGWinnipeg, Manitoba, R3E 0V9, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hackensack University Hospital (MRD-HCT)
RECRUITINGHackensack, New Jersey, 07601, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Nationwide Children's Hospital (NT-DMT)
NOT_YET_RECRUITINGColumbus, Ohio, 43205, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Nemours Children's Hospital, Delaware (MRD-HCT)
RECRUITINGWilmington, Delaware, 19803, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Oklahoma Children's Hospital (MRD-HCT)
NOT_YET_RECRUITINGOklahoma City, Oklahoma, 73104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Riley Children's Hospital (MRD-HCT)
RECRUITINGIndianapolis, Indiana, 46202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Riley's Children Hospital (NT-DMT)
NOT_YET_RECRUITINGIndianapolis, Indiana, 46202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Roswell Park (MRD-HCT)
RECRUITINGBuffalo, New York, 14203, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St Jude Children Hospital (NT-DMT)
NOT_YET_RECRUITINGMemphis, Tennessee, 38105, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St. Jude Children's Research Hospital (MRD-HCT)
RECRUITINGMemphis, Tennessee, 38105, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Texas Children's Hopsital (NT-DMT)
NOT_YET_RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Texas Children's Hospital (MRD-HCT)
RECRUITINGHouston, Texas, 77030, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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The Hospital for Sick Children (MRD-HCT)
NOT_YET_RECRUITINGToronto, Ontario, ON M5G 1E8, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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UNC Children's Hospital (MRD HCT)
NOT_YET_RECRUITINGChapel Hill, North Carolina, 27514, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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UNC Children's Hospital (NT-DMT)
NOT_YET_RECRUITINGChapel Hill, North Carolina, 27599., United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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UT San Antonio (NT-DMT)
NOT_YET_RECRUITINGSan Antonio, Texas, 78229, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universite de Montreal / Ste Justine (MRD HCT)
NOT_YET_RECRUITINGMontreal, Quebec, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Rochester (MRD-HCT)
NOT_YET_RECRUITINGRochester, New York, 14642, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Rochester (NT-DMT)
NOT_YET_RECRUITINGRochester, New York, 14642, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Wahington Univ in St Louis (NT-DMT)
NOT_YET_RECRUITINGSt Louis, Missouri, 63130, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Washington University in St Louis (MRD-HCT)
NOT_YET_RECRUITINGSt Louis, Missouri, 63130, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact