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New study tests program to boost daily function in older cancer survivors

NCT ID NCT05006482

Symptom relief Sponsor: University of Rochester Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests whether a program called GEM-S (geriatric evaluation and management with survivorship health education) can improve physical function in older cancer survivors. About 668 participants who have completed chemotherapy for lymphoma or solid tumors will be randomly assigned to GEM-S or usual care. The program includes a geriatric assessment, tailored health advice, and exercise sessions, aiming to help survivors maintain their ability to perform daily activities and improve mental well-being.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Geriatric evaluation and management plus survivorship health education (GEM-S)
What this could lead to
If successful, this could lead to a standard program that helps older cancer survivors maintain their physical abilities, mental sharpness, and quality of life after chemotherapy.
What could go wrong
This is a large phase 3 trial, but the intervention is complex and may not work better than usual care. Results depend on how well participants follow the program, and benefits may vary widely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 668 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2023

Expected to finish

Sep 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * PRACTICE CRITERIA: Participating practice clusters will be required to identify one (or more) oncologist and/or advanced practice practitioner (APPs; i.e., nurse practitioners, or physician assistants) as part of study eligibility. If another clinician is interested in participating, please contact University of Rochester Cancer Center (URCC) National Cancer Institute Community Oncology Research Program (NCORP) Research Base (RB) for approval * Oncologists/APPs/other clinicians must be licensed to practice * Oncologists/APPs/other clinicians must not have a plan to leave or retire from the NCORP practice within one year of enrolling into the study * PRACTICE CRITERIA: Support/buy-in from oncology physicians and/or APPs and/or other clinicians who are willing to participate in training and study procedures and enroll cancer survivors * ENTRY CRITERIA FOR ONCOLOGY PHYSICIANS/APPS/OTHER CLINICIANS: Oncology physicians/APPs/other clinicians must work at a participating site with no plans to leave that practice or retire within one year of enrollment into the study. We do not require that any or all oncology physicians and/or APPs at a practice setting agree to participate. Only one clinician is required for the practice cluster to be eligible. If another clinician (other than oncology physician or APP) is interested in participating, please contact URCC NCORP RB for approval * CANCER SURVIVORS: 65 years or older * CANCER SURVIVORS: Have completed or will have completed curative-intent treatment (e.g., surgery, chemotherapy, chemotherapy with radiation) for any solid tumor or lymphoma malignancy in last 6 months. If the survivor is receiving curative-intent chemotherapy, run-in study procedures can occur during the last 6 weeks of chemotherapy. * Cancer survivors who will receive or are receiving other treatments (e.g., hormonal treatment, monoclonal antibodies, immunotherapy, radiation) are eligible * For patients receiving neoadjuvant chemotherapy for curative intent, the run-in and baseline procedures can occur before or after surgery. Patients should be enrolled within 6 months from the end of surgery * CANCER SURVIVORS: Be willing and able to come in for study visits or willing to undergo informed consent and assessments remotely via tele-health visits * CANCER SURVIVORS: Be willing and able to provide informed consent and must sign consent in-person or remotely if it is not convenient or feasible to provide informed consent in-person * CANCER SURVIVORS: Speak and understand English and/or Spanish. Spanish-speaking cancer survivors are eligible as long as there are appropriate resources in place for completion of study procedures at the practice site. Registration for Spanish-speaking cancer survivors must be approved by the URCC NCORP Research Base after a phone call to determine the feasibility for the practice to enroll a Spanish-speaking participant * CAREGIVERS: 18 years or older * CAREGIVERS: Selected by the cancer survivor when asked if there is a "family member, partner, friend or caregiver (age 18 years or older) with whom you discuss or who can be helpful in health-related matters." A caregiver need not be someone who lives with the cancer survivor or provides direct hands-on care * CAREGIVERS: Speak and understand English and/or Spanish. Spanish-speaking caregivers are eligible as long as there are appropriate resources in place for completion of study procedures. Registration for Spanish-speaking caregivers must be approved by the URCC NCORP Research Base after a phone call to determine the feasibility for the practice to enroll a Spanish-speaking participant Exclusion Criteria: * CANCER SURVIVORS: Have a condition that precludes their ability to participate in informed consent or procedures (e.g., dementia) * CAREGIVERS: Caregivers unable to understand the informed consent form or study procedures due to cognitive, health, or sensory impairment will be excluded * Capacity to conduct informed consent procedures and study procedures will be determined by the coordinators in collaboration with the cancer survivors' oncologists. These procedures are similar to that of URCC 13070, which enrolled caregivers of older patients with advanced cancer

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Conditions

The condition(s) this trial relates to.

cancer lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lymphoma Malignant solid neoplasm

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The study's own enquiry address

    This study publishes an address for enquiries. See it below .

  2. The places running it

    45 sites. The list below names each one and where it is.

  3. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  4. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Chesapeake Regional Medical Center

    RECRUITING

    Chesapeake, Virginia, 23320, United States

    Contact Email: •••••@•••••

  • Community Medical Center

    RECRUITING

    Scranton, Pennsylvania, 18510, United States

    Contact Email: •••••@•••••

  • Fairview Southdale Hospital

    RECRUITING

    Edina, Minnesota, 55435, United States

  • Geisinger Cancer Center Dickson City

    RECRUITING

    Dickson City, Pennsylvania, 18519, United States

    Contact Email: •••••@•••••

  • Geisinger Medical Center

    RECRUITING

    Danville, Pennsylvania, 17822, United States

    Contact Email: •••••@•••••

  • Geisinger Wyoming Valley/Henry Cancer Center

    RECRUITING

    Wilkes-Barre, Pennsylvania, 18711, United States

    Contact Email: •••••@•••••

  • HSHS Sacred Heart Hospital

    SUSPENDED

    Eau Claire, Wisconsin, 54701, United States

  • Hawaii Cancer Care - Westridge

    RECRUITING

    ‘Aiea, Hawaii, 96701, United States

    Contact Email: •••••@•••••

  • Hawaii Cancer Care Inc - Waterfront Plaza

    RECRUITING

    Honolulu, Hawaii, 96813, United States

  • Helen F Graham Cancer Center

    RECRUITING

    Newark, Delaware, 19713, United States

  • Hennepin County Medical Center

    RECRUITING

    Minneapolis, Minnesota, 55415, United States

  • Highland Hospital

    RECRUITING

    Rochester, New York, 14620, United States

  • Kaiser Permanente-Fremont

    RECRUITING

    Fremont, California, 94538, United States

  • Kaiser Permanente-San Francisco

    RECRUITING

    San Francisco, California, 94115, United States

  • Kapiolani Medical Center for Women and Children

    RECRUITING

    Honolulu, Hawaii, 96826, United States

  • Lake Regional Hospital

    RECRUITING

    Osage Beach, Missouri, 65065, United States

    Contact Email: •••••@•••••

  • Lakeview Hospital

    RECRUITING

    Stillwater, Minnesota, 55082, United States

  • Lewis and Faye Manderson Cancer Center

    RECRUITING

    Tuscaloosa, Alabama, 35401, United States

  • Marshfield Medical Center - Weston

    RECRUITING

    Weston, Wisconsin, 54476, United States

    Contact Email: •••••@•••••

  • Marshfield Medical Center-River Region at Stevens Point

    RECRUITING

    Stevens Point, Wisconsin, 54482, United States

    Contact Email: •••••@•••••

  • Medical Oncology Hematology Consultants PA

    RECRUITING

    Newark, Delaware, 19713, United States

  • Minnesota Oncology Hematology PA-Woodbury

    RECRUITING

    Woodbury, Minnesota, 55125, United States

  • Monticello Cancer Center

    RECRUITING

    Monticello, Minnesota, 55362, United States

  • Northwell Health/Center for Advanced Medicine

    RECRUITING

    Lake Success, New York, 11042, United States

  • Novant Health Breast Surgery - Greensboro

    RECRUITING

    Greensboro, North Carolina, 27403, United States

  • Novant Health Cancer Institute - Kernersville

    RECRUITING

    Kernersville, North Carolina, 27284, United States

  • Novant Health Cancer Institute - Mount Airy

    RECRUITING

    Mount Airy, North Carolina, 27030, United States

  • Novant Health Cancer Institute - Statesville

    RECRUITING

    Stateville, North Carolina, 28625, United States

  • Novant Health Cancer Institute - Thomasville

    RECRUITING

    Thomasville, North Carolina, 27360, United States

  • Novant Health Forsyth Medical Center

    RECRUITING

    Winston-Salem, North Carolina, 27103, United States

  • Noyes Memorial Hospital/Myers Cancer Center

    RECRUITING

    Dansville, New York, 14437, United States

    Contact Email: •••••@•••••

  • OSF Saint Anthony's Health Center

    RECRUITING

    Alton, Illinois, 62002, United States

  • Pali Momi Medical Center

    RECRUITING

    ‘Aiea, Hawaii, 96701, United States

  • Park Nicollet Clinic - Saint Louis Park

    RECRUITING

    Saint Louis Park, Minnesota, 55416, United States

  • Pluta Cancer Center

    RECRUITING

    Rochester, New York, 14623, United States

  • Regions Hospital

    RECRUITING

    Saint Paul, Minnesota, 55101, United States

  • Rice Memorial Hospital

    RECRUITING

    Willmar, Minnesota, 56201, United States

  • Saint Vincent Hospital Cancer Center Green Bay

    RECRUITING

    Green Bay, Wisconsin, 54301, United States

  • Saint Vincent Hospital Cancer Center at Saint Mary's

    RECRUITING

    Green Bay, Wisconsin, 54303, United States

  • South Central Medical and Resource Center

    RECRUITING

    Lindsay, Oklahoma, 73052, United States

  • Straub Clinic and Hospital

    RECRUITING

    Honolulu, Hawaii, 96813, United States

  • ThedaCare Regional Cancer Center

    RECRUITING

    Appleton, Wisconsin, 54911, United States

    Contact Email: •••••@•••••

  • Tripler Army Medical Center

    RECRUITING

    Honolulu, Hawaii, 96859, United States

  • University of Rochester

    RECRUITING

    Rochester, New York, 14642, United States

  • Wilmot Cancer Institute at Webster

    RECRUITING

    Webster, New York, 14580, United States

    Contact Email: •••••@•••••

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