Could a keto diet boost brain zaps for depression?

NCT ID NCT07376018

First seen Jun 24, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This study tests whether adding a ketogenic (low-carb) diet to a non-invasive brain stimulation treatment called iTBS helps people with treatment-resistant depression feel better. Sixty adults will follow either a keto diet or a standard healthy diet for three weeks, then receive personalized brain stimulation while staying on their diet. Researchers will measure changes in depression scores, ketone levels, and brain scans to see if the combination is safe and effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
ketogenic diet
What this could lead to
If it works, this could point toward a new way to boost the effects of brain stimulation for people with hard-to-treat depression.
What could go wrong
This is a small early-stage trial with only 60 people. The diet is hard to follow, and the added benefit over brain stimulation alone is unproven. Side effects like low blood sugar or stomach issues are possible.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Sunnybrook Health Sciences Centre

    Toronto, Ontario, M4N 3M5, Canada

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