TREATMENT RESISTANT DEPRESSION (TRD)

This early-stage trial tests a personalized approach to deep brain stimulation (DBS) for people with severe depression that hasn't improved with other treatments. Researchers use brain scans and recordings to find the best spot and settings for each patient's implant. The goal is…

This study tests two different forms of transcranial magnetic stimulation (TMS) in 60 adults with depression that hasn't responded to at least two medications. Participants receive either intermittent or continuous theta burst stimulation over two weeks, then are followed for 12 …

This study tests whether a gentle, at-home brain stimulation technique called tDCS is safe and practical for people with depression that hasn't improved with standard treatments. Ten adults in San Diego will use a headset for three hours a day, five days a week, for two weeks, un…

This study tests if a new drug called ALTO-207 can reduce depression symptoms in adults whose depression hasn't improved with at least two other antidepressants. About 178 people will receive either the drug or a placebo. The main goal is to see if their depression scores improve…

This study compares a step-by-step, personalized treatment plan (algorithm-guided) to usual care for people with treatment-resistant depression. About 80 adults aged 18-65 who have not felt stable remission in the past year will participate. The goal is to see if the algorithm le…

This study tests whether adding therapy sessions before and after esketamine (Spravato®) nasal spray can improve mood and daily function in adults with treatment-resistant depression. About 20 people will be randomly assigned to receive esketamine with or without extra therapeuti…

This study tests whether using magnetic brain stimulation (TMS) right before electroconvulsive therapy (ECT) can make ECT work better and faster for people with severe, treatment-resistant depression. About 50 adults will receive both treatments, and researchers will measure chan…

This study tests a non-invasive light therapy called transcranial photobiomodulation (tPBM) for people with treatment-resistant depression. It aims to see if different light frequencies can improve depression symptoms, especially physical ones like pain or fatigue. About 40 adult…

This study looks at whether adding coaching sessions can make ketamine or esketamine work better for people with treatment-resistant depression. About 20 adults who already get ketamine at Massachusetts General Hospital will try 12 coaching sessions over 3 months. The goal is to …

This study tests whether a single dose of intravenous ketamine can rapidly reduce depression symptoms in 30 adults with treatment-resistant depression. Researchers will measure changes in key brain chemicals (GABA and glutamate) using brain scans and blood tests. The goal is to u…

This study looks at whether adding structured exercise to a type of brain stimulation called iTBS can improve depression symptoms in people whose depression hasn't responded well to standard treatments. Twenty physically inactive adults with difficult-to-treat depression will eit…

This study follows 100 adults with treatment-resistant depression who are prescribed esketamine nasal spray as part of their regular care. Researchers will track how well the drug works, who responds best, and how it affects daily life, work, and social functioning. The goal is t…