Could a pill supercharge brain stimulation for depression?
NCT ID NCT07227103
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether adding a drug called NRX-101 (a mix of D-cycloserine and lurasidone) to transcranial magnetic stimulation (TMS) helps people with treatment-resistant depression more than TMS alone. About 400 adults who have not had TMS before will receive either the drug or a placebo alongside a one-day TMS session. Researchers will measure depression and suicidal thoughts after six weeks to see if the combination improves outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- NRX-101 (D-cycloserine and lurasidone)
- What this could lead to
- If successful, this could provide a more effective treatment option for people with treatment-resistant depression, potentially doubling response and remission rates compared to TMS alone.
- What could go wrong
- This is an early-stage trial (Phase 2/3) with 400 participants, so results may not apply to everyone. The combination drug may cause side effects, and the placebo group also receives TMS, so the added benefit of NRX-101 is uncertain.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Cohen and Associates
Sarasota, Florida, 34239, United States
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HOPE Accelerated Care
West Palm Beach, Florida, 33417, United States
Contact Email: •••••@•••••
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Harvard Mclean Hospital
Belmont, Massachusetts, 02478, United States
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