Magic mushroom compound targets Depression's Joy-Sapping symptom

This study explores whether psilocybin, the active ingredient in magic mushrooms, can help people with depression who have lost the ability to feel pleasure (anhedonia). Researchers will give 85 participants two doses of psilocybin, sometimes blocking its psychedelic effects with another drug, and use brain scans to see how it affects reward and pleasure pathways. The goal is to understand if the psychedelic experience itself is key to any mood benefits.