DEPRESSION - MAJOR DEPRESSIVE DISORDER

This study tests a new care package for adults aged 65 and older who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized guidance, and ongoing support. Researchers will compare this approach to usu…

This study will see if an artificial intelligence (AI) tool can analyze speech recordings to help identify people with memory problems who need a specialist dementia evaluation. Researchers will record 440 adults over 50 doing speaking tasks and cognitive tests. The goal is to de…

This study will test if a smartphone app that analyzes speech can accurately screen for depression and anxiety in 80 university students aged 16-25. Participants will complete speaking tasks and standard questionnaires to see how well the app's voice analysis matches traditional …

This study tests a type of brain stimulation called theta burst stimulation (TBS) in 120 adults and teens with depression that hasn't improved with standard treatments. Participants will receive either real or fake stimulation alongside their usual antidepressants to see if TBS c…

This study tests whether an AI-assisted writing program can help Chinese teenagers (ages 10-19) who are struggling with grief after losing a loved one. Participants will be split into three groups: one using AI feedback, one writing without feedback, and one free writing. The goa…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with mindfulness-based therapy can help ease symptoms of posttraumatic stress disorder (PTSD). Thirty adults with PTSD will receive psilocybin along with either standard suppo…

This early-stage study tests whether a non-invasive brain stimulation technique called rTMS is safe and tolerable for treating depression and fatigue in adults with multiple sclerosis (MS). About 20 participants with MS and moderate-to-severe depression will receive daily rTMS se…

This study will test whether an 8-week mindfulness-based psychoeducation program can reduce depression symptoms, improve stress tolerance, and help with emotion regulation in adults diagnosed with major depression. About 70 outpatients in Gaziantep, Turkey, who have been treated …

This study tests a fast-acting brain stimulation method called a-iTBS in 45 teens aged 12-18 with major depression. The goal is to see if it is safe, acceptable, and helps reduce depressive symptoms. Participants will receive either real or fake stimulation to compare effects.

This pilot study tests whether a gentle, non-invasive brain stimulation technique called tACS can safely speed up recovery from depression in teenagers aged 12 to 18. Participants will continue their usual medication and receive either real or fake tACS sessions. The goal is to s…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can be safely and acceptably used alongside group cognitive behavioral therapy for adults with major depression. Thirty participants aged 21-60 with current depressive symptoms will receive the combina…

This small pilot study tests whether a gentle, non-invasive brain stimulation technique called tACS can safely reduce depression symptoms in 30 adolescents (ages 12-18) who are experiencing their first depressive episode and have never taken antidepressants. Researchers will meas…

This study aims to see if 5 days of accelerated brain stimulation (called iTBS) can quickly reduce depression symptoms in adults. Participants will receive either real or sham (fake) stimulation over 50 sessions in 5 days. Researchers will track mood changes, brain scans, and bio…

This study tests a computer-based training program called action-based cognitive remediation (ABCR) to see if it can improve thinking, social, and work skills in people with various psychiatric conditions like depression, schizophrenia, and PTSD. 160 participants will first wait …

This study tests whether a self-guided mobile app for cognitive behavioral therapy for insomnia (CBTI) can improve sleep in 144 active-duty service members. Participants use the app for five weeks, and researchers measure changes in insomnia severity, depression, PTSD symptoms, a…

This study looks at how well the antidepressant escitalopram works in people experiencing their first episode of major depression who have never taken medication for it. Researchers will track changes in mood, thinking, and side effects over 8 weeks in 200 adults aged 18-65. They…

This study tests whether combining psilocybin (the active ingredient in magic mushrooms) with the antidepressant trazodone can reduce depression symptoms in people who haven't gotten better with other treatments. The key question is whether blocking the psychedelic 'trip' with tr…

This small pilot study tests whether a non-invasive device that gently stimulates the brain during sleep can increase deep sleep in adults with depression. Researchers want to see if better deep sleep helps with memory, thinking, and mood. Participants wear a headband that record…

This pilot study tests whether a headband that plays sounds timed to your brain's alpha waves can improve sleep for people with both depression and insomnia. Twenty-five participants will wear the headband and a sleep tracker for four weeks, alternating between active stimulation…

This study tests whether an 8-week psychoeducation program, based on Acceptance and Commitment Therapy, can help people with depression feel more meaning in life and take better care of themselves. About 46 adults receiving TMS treatment will be randomly assigned to either the pr…

This study tests whether a genetic test can help doctors choose the best antidepressant for people with major depression. 570 adults in Morocco will be randomly assigned to either treatment guided by their genetic results or standard care. The goal is to see if the genetic approa…

This study tests whether using a person's genetic test results to guide medication decisions, delivered by community pharmacists, can improve depression symptoms. About 220 adults starting or changing antidepressants will be randomly assigned to receive this personalized medicati…

This study tests a two-session, Zoom-based therapy designed for Deaf adults who use American Sign Language. The goal is to change negative beliefs about mental health treatment and encourage people to seek help. Researchers hope this will reduce suicide risk and improve symptoms …

This study tests a non-invasive device that uses gentle electrical currents to the brain to reduce symptoms of major depression. It involves 214 adults who have not gotten enough relief from antidepressants. The goal is to see if this closed-loop stimulation can safely improve mo…

This study tests whether selenium supplements can reduce depression symptoms in 172 children and teens aged 12-18 with major depressive disorder. Participants will take selenium or a placebo, and researchers will measure changes in depression scores over time. The goal is to see …

This study aims to find out if very short psychological treatments can effectively reduce symptoms of anxiety, depression, and stress-related physical symptoms. Researchers will compare four different approaches: group therapy lasting eight sessions, group therapy lasting four se…

This study is testing whether a smartphone app can help medical students feel less depressed and more resilient to stress. 220 students will be randomly assigned to either get full access to the app or a basic version for three months. Researchers will compare the two groups to s…

This study reviews data from 80 veterans and first responders who completed a 12-week wellness program that included therapy, physical training, and nutrition advice. Researchers will analyze sleep, activity, heart health, and mental health surveys to see how the program helped. …

This study aims to improve how doctors choose electroconvulsive therapy (ECT) settings for people with severe depression or catatonia. Researchers will use real-time brain monitoring to see how different stimulation levels affect brain activity and blood flow. About 64 adults alr…

This study looks at how menopause changes the way the body processes escitalopram, a common antidepressant. Researchers will compare drug levels in premenopausal and postmenopausal women aged 40-60 who take the medication for depression or anxiety. The goal is to help doctors per…

This study looks at how natural hormone changes during the menstrual cycle impact brain areas linked to mood and irritability in teenage girls at risk for suicide. Fifty girls aged 12-16 will take either a birth control pill to stabilize hormones or a placebo for 8 weeks each, wh…

This study looks at whether special cells in the eye can help predict how well people with hard-to-treat depression will respond to a brain stimulation therapy called TMS. 44 adults with treatment-resistant depression will receive TMS and have their eyes tested before and after t…

This study will enroll 2000 adults with major depressive disorder or bipolar depression to understand why some people respond to treatment and others do not. Researchers will analyze clinical symptoms, genetics, metabolism, and immune markers. Participants may also be contacted f…

This study aims to find out how common depression is among medical students at Sohag University. Researchers will survey 300 students aged 18 to 25 to measure depression rates and understand the factors that contribute to it. The goal is to raise awareness and improve mental heal…

This study uses brain scans (MEG and MRI) to understand the brain patterns linked to suicidal thoughts and behaviors in young people aged 14-24. Participants include those who have attempted suicide, those with ongoing suicidal thoughts, and healthy controls. High-risk participan…

This study tests whether watching a short video can reduce negative beliefs about depression and encourage teens to seek help. About 500 adolescents aged 8-18 in China will take part. Some will watch a video about depression stigma, while others watch a neutral video about eye he…

This study compares two methods for safely stopping antidepressants in adults whose depression is in remission. Participants will be randomly assigned to either a standard gradual dose reduction or a more precise 'hyperbolic' reduction over several weeks. The goal is to see which…

This study looks at how medication, talk therapy, or both together change the way depression symptoms connect and influence each other over time. Researchers will track 90 adults with mild to moderate depression using smartphone surveys to see which treatment leads to better symp…

This study looks at whether a tailored exercise program can improve how quickly muscles recover oxygen after activity in menopausal women with depression. Researchers will compare the exercise group to a group doing a non-exercise activity. The goal is to understand the link betw…

This study looks at how two different types of noninvasive brain stimulation change brain activity and heart function in people with both PTSD and major depression. About 50 adults will receive both active and sham stimulation in a random order, with measurements taken right befo…

This study looks at two common talk therapies for depression—cognitive behavioral therapy (CBT) and short-term psychodynamic psychotherapy (STPP)—to see if having sessions twice a week works better than once a week. It also tests whether matching people to the therapy that best f…