DEPRESSION - MAJOR DEPRESSIVE DISORDER

This study aims to understand how a single dose of psilocybin (the active compound in 'magic mushrooms'), given with different types of therapy, might help people with PTSD. It will enroll 30 adults with moderate to severe PTSD to see how their brain activity and symptoms change.…

This study aims to see if adding a selenium supplement to standard depression medication (fluoxetine) helps reduce depression symptoms in teenagers aged 12-18. It will involve 172 participants who will be randomly assigned to receive either the supplement or a placebo (inactive p…

This study is testing a new approach for people with depression that hasn't improved with standard treatments. Researchers want to see if psilocybin, a compound from 'magic mushrooms,' can relieve depression even when its psychedelic effects are blocked by another drug called tra…

This study is testing whether using a person's genetic test results to guide antidepressant prescriptions leads to better depression control. About 220 adults starting or adjusting their antidepressant medication will be randomly assigned to either receive this personalized, phar…

This study aims to see if using a genetic test to guide antidepressant choice works better than standard care for adults with major depression in Morocco. About 570 participants will be randomly assigned to have their treatment chosen either with the help of their genetic test re…

This study is testing whether a gentle, non-invasive brain stimulation device can help teenagers with their first episode of depression feel better faster when used alongside a standard medication. Thirty teens aged 12-18 will use the device for 20 sessions over 4 weeks to see if…

This is a small, early-stage study to test a faster version of a non-invasive brain stimulation treatment for teenagers with depression. Over 10 days, 45 participants will receive either real or sham stimulation to see if the real treatment is safe, acceptable, and shows signs of…

This study is testing whether a faster, 5-day version of magnetic brain stimulation can help adults with depression. Researchers will compare the real treatment to a placebo (sham) version in 264 participants. They'll measure changes in depression symptoms, brain activity, and em…

This study is testing whether a non-invasive brain stimulation device worn on the head can reduce symptoms of major depression. It will involve about 214 adults with moderate to severe depression who haven't gotten enough relief from at least one antidepressant medication. Partic…

This study aims to find the best way for people to safely stop taking antidepressant medication when their depression is under control. It will compare two different tapering (gradual dose reduction) methods in 150 adults in Italy who have been stable on antidepressants for at le…

This study is testing a new support package for older adults who have two or more long-term health problems, like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized guidance, and ongoing support to help manage their health. Researchers w…

This study aims to improve talk therapy for depression. It will test if having therapy sessions twice a week works better than once a week, using two common approaches: Cognitive Behavioral Therapy (CBT) and Psychodynamic Therapy. Researchers will enroll 200 adults with depressio…

This study is testing whether adding a traditional Chinese herbal formula, called Compound Ciwujia Granules, to standard antidepressant medication (SSRIs) can help reduce symptoms of depression more effectively. It will involve 60 adults with a specific pattern of depression desc…

This study is testing a brief, two-session online therapy program designed specifically for Deaf adults. The goal is to see if this therapy can help change negative beliefs about mental health treatment and encourage more people to seek professional help. Researchers will also ch…

This study tests whether very short psychological treatments can help reduce symptoms of anxiety, depression, and physical symptoms related to stress. Researchers will compare four or eight sessions of group or individual therapy against a relaxation control group. The goal is to…

This small pilot study is testing whether a gentle, non-invasive brain stimulation device can help teens with depression feel better faster. Thirty teenagers who are already on stable depression medication will use the device or a fake version for 20 sessions over 4 weeks. Resear…

This small pilot study is testing whether a gentle, non-invasive electrical headband worn during sleep can increase deep sleep in adults with depression. Researchers want to see if boosting deep sleep leads to better memory, thinking speed, and mood. Participants will wear the he…

This study aims to see if psilocybin, the active compound in 'magic mushrooms,' is safe and tolerable for people with spinal cord injuries who also have depression. Researchers will give 30 veterans with spinal cord injuries different doses of psilocybin to check for side effects…

This pilot study is testing whether a self-guided smartphone app can help service members with insomnia sleep better. 144 active-duty military personnel will be randomly assigned to either use the app for five weeks or wait. Researchers will measure changes in sleep quality, dayt…

This study aims to see if an 8-week mindfulness-based education program can help adults diagnosed with depression. It will measure if the program reduces the severity of their symptoms, helps them better tolerate distress, and improves their ability to manage difficult emotions. …

This study aims to see if using a mental health app for three months can help medical students feel less depressed and more resilient to stress. Researchers will compare 220 students who get full access to the app against a group with limited access. The goal is to find new ways …

This study is testing whether a tailored exercise program can improve how the body's cells produce energy and reduce depression symptoms in menopausal women. It will compare the exercise program to a non-exercise therapy in 52 women receiving psychiatric care. The main goal is to…

This study is testing a mental health support program for family members of people who have survived intensive care. The program uses a telehealth platform to help families manage anxiety, depression, and stress. Researchers want to see if this approach is practical and helpful f…

This study tests whether a digital mental health program helps people recovering from intensive care. 150 patients will either use a special app with coaching and support or receive standard follow-up care. Researchers will compare anxiety, depression, and PTSD symptoms after six…

This study is testing whether adding a special 8-week talk therapy program to standard brain stimulation treatment helps people with depression. The program teaches skills for finding more meaning in life and improving daily self-care. Researchers will compare two groups: one get…

This study aims to find out why some people with depression get better with treatment while others do not. Researchers will collect detailed information from 2,000 participants, including genetic data, blood tests, and surveys about symptoms and life experiences. The goal is to u…

This study aims to find out if special light-sensitive cells in the back of the eye can help predict which patients with hard-to-treat depression will respond well to a non-invasive brain stimulation therapy. Researchers will give 44 participants with treatment-resistant depressi…

This study aims to understand if menopause changes how a woman's body processes the common antidepressant escitalopram. Researchers will observe 94 women aged 40-60, comparing those before and after menopause. The goal is to gather information that could help doctors personalize …

This study is looking back at data from a 12-week wellness program designed for veterans and first responders. Researchers will analyze information from about 80 past participants to see if the program helped with anxiety, depression, PTSD, sleep, and overall quality of life. The…

This study aims to measure how common depression is among medical students at Sohag University. It will survey 300 students aged 18 to 25 to understand the scale of this mental health challenge. The goal is to gather information that could help improve support for students in the…

This study aims to see if watching educational videos can reduce the stigma surrounding depression and encourage teens to seek help. Researchers will recruit 500 adolescents in China, both with and without depression, and show them different videos. They will then measure changes…

This study aims to understand how two different types of non-invasive brain stimulation affect the brain and body's stress response in people who have both PTSD and depression. Researchers will measure brain activity and heart rate in 50 participants before and after a single sti…