DEPRESSION - MAJOR DEPRESSIVE DISORDER
Clinical trials for DEPRESSION - MAJOR DEPRESSIVE DISORDER explained in plain language.
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New trial combines lifestyle changes and Weight-Loss drug to boost mental health
Disease control Not yet recruitingThis study tests whether a personalized program of exercise, diet, sleep support, social activities, and a weight-loss drug (semaglutide) can improve mental functioning in 140 adults with depression, bipolar disorder, or schizophrenia. Participants are randomly assigned to the pe…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Ludwig-Maximilians - University of Munich • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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Can your genes guide better depression treatment? new trial aims to find out.
Disease control Not yet recruitingThis study will test whether having a pharmacist review a patient's genetic test results can improve treatment for major depression. 220 adults in Pennsylvania who are starting or changing antidepressant medication will be randomly assigned to either receive this specialized medi…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of Pittsburgh • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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Could a Head-Zapping device lift teen depression?
Disease control Not yet recruitingThis pilot study tests whether a non-invasive brain stimulation technique called tACS can help teens (ages 12-18) with major depression when added to their usual medication. Thirty participants will receive either real or sham stimulation daily for several weeks. The goal is to s…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: First Affiliated Hospital of Chongqing Medical University • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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New program aims to keep seniors with multiple illnesses out of the hospital
Disease control Not yet recruitingThis study tests a comprehensive management service package for older adults (65+) who have two or more chronic conditions like high blood pressure, diabetes, or arthritis. The package includes digital tools, personalized lifestyle advice, and long-term support. Researchers will …
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Xuanwu Hospital, Beijing • Aim: Disease control
Last updated Jun 26, 2026 12:59 UTC
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Can your voice reveal depression? new app puts speech analysis to the test
Diagnosis Not yet recruitingThis study will test if a smartphone app that analyzes speech can accurately screen for depression and anxiety in university students. Researchers will enroll 80 students aged 16 to 25 and compare the app's results with standard questionnaires. The goal is to see if voice pattern…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: Accexible • Aim: Diagnosis
Last updated Jun 27, 2026 12:31 UTC
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AI listens for dementia: new speech test could speed up diagnosis
Diagnosis Not yet recruitingThis observational study will enroll 440 Danish-speaking adults over 50 to see if an artificial intelligence model can detect dementia and mild cognitive impairment from speech recordings. Participants will complete standard cognitive tests and describe a picture while being reco…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: Zealand University Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 12:29 UTC
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Can a smartphone app help stroke survivors feel better?
Symptom relief Not yet recruitingThis study tests a mobile app called Maya that teaches cognitive behavioral therapy skills to adults who recently had a stroke and feel depressed or anxious. Ten participants will use the app for a few weeks to see if it is easy to use and helps improve their mood. The goal is to…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Weill Medical College of Cornell University • Aim: Symptom relief
Last updated Jul 02, 2026 00:00 UTC
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Can a headband that plays pink noise cure insomnia in depressed people?
Symptom relief Not yet recruitingThis pilot study tests whether a headband that delivers timed sound pulses (pink noise) can improve sleep in 25 people with both depression and insomnia. Participants wear the device nightly for four weeks, alternating between active stimulation and sham (placebo) sound. The goal…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Wake Forest University Health Sciences • Aim: Symptom relief
Last updated Jun 28, 2026 00:00 UTC
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New study tests Mind-Body combo for depression and body aches in asian americans
Symptom relief Not yet recruitingMany Asian Americans with depression also suffer from physical symptoms like pain or fatigue, but no proven treatment addresses both together. This study will test whether combining a stress management program with Qigong/Tai Chi movements is practical and acceptable for 70 adult…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 14:02 UTC
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Zoom therapy aims to break barriers for deaf individuals seeking mental health help
Symptom relief Not yet recruitingThis study tests a two-session Zoom-based therapy designed to change beliefs about mental health treatment in Deaf adults who are not currently in care. Researchers will compare those who receive the therapy to a waitlist group to see if it increases treatment-seeking and reduces…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of Rochester • Aim: Symptom relief
Last updated Jun 27, 2026 14:01 UTC
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5-Day brain zaps could lift depression fast
Symptom relief Not yet recruitingThis study tests whether 5 days of accelerated transcranial magnetic stimulation (TMS) can quickly reduce depression symptoms. 264 adults with major depressive disorder will receive either real or sham stimulation, along with brain scans and mood tracking. The goal is to see if t…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of California, Davis • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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Phone coaching plus app could ease depression in pregnancy
Symptom relief Not yet recruitingThis study tests a digital cognitive behavioral therapy (CBT) program with weekly phone coaching for pregnant women with depression. Researchers will enroll 1,000 women between 12 and 22 weeks pregnant who have depressive symptoms. The goal is to see if the program is easy to use…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of Turku • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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Could a headset lift depression? new trial tests home Brain-Zap therapy
Symptom relief Not yet recruitingThis study tests whether a high-dose version of a gentle brain-stimulation device (tDCS) used at home works better than the standard dose for easing major depression. About 270 adults with depression will use the device daily and be monitored for changes in mood and thinking. The…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Ionclinics & Deionic SL • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
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Can a single therapy session keep suicidal teens safer after hospital discharge?
Symptom relief Not yet recruitingThis trial compares two short, one-session therapies for teens aged 12-17 hospitalized for suicidal thoughts or attempts. One therapy (CAMS-BI) focuses on understanding and addressing the personal reasons behind suicidal feelings, while the other (Stanley-Brown Safety Planning) b…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Symptom relief
Last updated Jun 27, 2026 13:03 UTC
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New hope for seniors with stubborn depression?
Symptom relief Not yet recruitingThis study tests whether lumateperone (Caplyta) can help older adults (60+) whose depression hasn't improved with other treatments. One hundred participants will take either the drug or a placebo alongside their current antidepressant for 10 weeks. Researchers will measure change…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE3 • Sponsor: Eric Lenze • Aim: Symptom relief
Last updated Jun 27, 2026 13:01 UTC
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AI writing coach aims to ease teen grief in landmark trial
Symptom relief Not yet recruitingThis study tests whether an AI-assisted writing program can help Chinese teenagers (ages 10-19) who are struggling with prolonged grief after losing a loved one. Participants will complete three guided writing sessions over six days, with some receiving personalized AI feedback. …
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Peking University • Aim: Symptom relief
Last updated Jun 27, 2026 12:32 UTC
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Magic mushroom therapy for depression? new trial tests psilocybin and CBT in groups
Symptom relief Not yet recruitingThis phase 2 trial will test whether giving psilocybin (the active ingredient in magic mushrooms) along with group cognitive behavioral therapy is acceptable and feasible for people with major depression. Thirty adults with current depressive symptoms will receive two doses of ps…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE2 • Sponsor: University of California, Los Angeles • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Could magnetic pulses ease MS depression and fatigue?
Symptom relief Not yet recruitingThis pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) is safe and helpful for depression and fatigue in adults with multiple sclerosis (MS). About 20 participants will receive daily rTMS sessions for 5 days, with assessments before, after, and at a 4-…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE1 • Sponsor: University of Calgary • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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Can computer exercises sharpen thinking in mental illness?
Symptom relief Not yet recruitingThis study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: The Royal Ottawa Mental Health Centre • Aim: Symptom relief
Last updated Jun 27, 2026 12:10 UTC
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New brain zaps could lift depression when pills fail
Symptom relief Not yet recruitingThis study tests a type of brain stimulation called theta burst stimulation (TBS) for people with depression that hasn't improved with medication. About 120 adults and teens will either get real TBS or a fake version first, then real TBS later. Researchers will measure changes in…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Jung-Sun Lee • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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Mindfulness program aims to ease depression symptoms
Symptom relief Not yet recruitingThis study tests whether an 8-week mindfulness-based psychoeducation program can reduce depression symptoms, improve stress tolerance, and help with emotion regulation in adults diagnosed with major depression. About 70 outpatients aged 18-65 who have been treated for depression …
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of Gaziantep • Aim: Symptom relief
Last updated Jun 27, 2026 11:04 UTC
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New study aims to personalize depression treatment with escitalopram
Symptom relief Not yet recruitingThis study looks at how well and safely the antidepressant escitalopram works in people experiencing their first episode of major depression who have never taken medication for it. Two hundred adults aged 18 to 65 will take escitalopram for 8 weeks, and researchers will track the…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Peking University • Aim: Symptom relief
Last updated Jun 27, 2026 11:02 UTC
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Could quick brain zaps lift teen depression? small study aims to find out
Symptom relief Not yet recruitingThis pilot study will test a type of brain stimulation called accelerated intermittent theta-burst stimulation (a-iTBS) in 45 adolescents aged 12-18 with major depressive disorder. Participants will get either real or sham stimulation, guided by MRI scans. The goal is to see if i…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: First Affiliated Hospital of Chongqing Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC
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New study: could a simple class boost meaning and Self-Care in depression?
Symptom relief Not yet recruitingThis study tests whether an 8-week psychoeducation program, based on Acceptance and Commitment Therapy, can help people with depression feel more meaning in life and take better care of themselves. About 46 adults receiving TMS treatment will either join the program or continue u…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Baskent University • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC
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App aims to lift depression in stressed med students
Symptom relief Not yet recruitingThis study tests whether a mental health app called Intellect can reduce depression and improve resilience in medical students. 220 students will be split into two groups: one gets full app access, the other gets basic access. Researchers will check changes in mood, anxiety, and …
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: National University of Malaysia • Aim: Symptom relief
Last updated Jun 27, 2026 09:04 UTC
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New app aims to tackle insomnia in the military
Symptom relief Not yet recruitingThis pilot study will test whether a smartphone app that teaches cognitive behavioral therapy for insomnia (CBTI) can improve sleep in 144 active-duty service members. Participants will use the app for five weeks, and researchers will measure changes in insomnia severity, depress…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Madigan Army Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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Could a common mineral ease teen depression? new trial investigates
Symptom relief Not yet recruitingThis Phase 2 trial will test whether adding selenium supplements to standard antidepressant medication (fluoxetine) can improve depression symptoms in 172 children and adolescents aged 12-18 with major depressive disorder. Participants will receive either selenium or a placebo fo…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE2 • Sponsor: First Affiliated Hospital of Chongqing Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC
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Can just 4 therapy sessions beat anxiety and depression?
Symptom relief Not yet recruitingThis study tests whether very short (4 or 8 sessions) psychological treatments can reduce symptoms of anxiety, depression, and stress-related physical complaints. About 184 adults with mild to moderate symptoms will be randomly assigned to group or individual therapy, or a relaxa…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Universidad de Córdoba • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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New brain stimulator aims to lift depression when pills fail
Symptom relief Not yet recruitingThis study tests a device that sends gentle electrical currents to the brain, automatically adjusting to your brain's own rhythms, to ease depression symptoms. It involves 214 adults who have tried at least one antidepressant without enough relief. Participants will receive eithe…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Pulvinar Neuro, LLC • Aim: Symptom relief
Last updated Jun 27, 2026 08:04 UTC
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Can a depression drug tame the psychedelic trip without killing the benefits?
Symptom relief Not yet recruitingThis phase 2 trial tests whether adding the antidepressant trazodone to psilocybin can reduce the intense psychedelic effects while keeping the mood-lifting benefits. 112 adults with treatment-resistant depression will receive either psilocybin alone, psilocybin plus a low or hig…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE2 • Sponsor: Centre Hospitalier St Anne • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC
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Could a gentle brain current lift teen depression without drugs?
Symptom relief Not yet recruitingThis pilot study tests whether a non-invasive device that sends a mild alternating current to the brain (tACS) can safely ease depression symptoms in 30 teenagers who have never taken antidepressants. Participants will receive daily sessions over several weeks, and researchers wi…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: First Affiliated Hospital of Chongqing Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Could a bike ride help your brain? new study explores exercise, cell health, and depression
Knowledge-focused Not yet recruitingThis study looks at how exercise affects a natural cell cleanup process called autophagy, which may be linked to depression. Researchers will have 120 healthy adults do a cycling test and take blood samples to measure changes in autophagy and related genes. The goal is to better …
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of Zurich • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:03 UTC
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New online tool aims to help dementia caregivers fight depression
Knowledge-focused Not yet recruitingThis study looks at better ways to screen caregivers of people with dementia for depression and connect them to online treatment. About 15 adult caregivers who show mild depression symptoms will test a new app. The goal is to see if the approach is easy to use and helps more peop…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Dartmouth-Hitchcock Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Brain scan study to finally test if low serotonin causes depression
Knowledge-focused Not yet recruitingThis study will test the long-standing theory that depression is caused by low serotonin levels in the brain. Researchers will give a single dose of fenfluramine (a drug that releases serotonin) to 46 people—half with depression and half healthy—and use PET brain scans to measure…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Imperial College Healthcare NHS Trust • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Scientists to watch depression treatment reshape the brain in real time
Knowledge-focused Not yet recruitingThis study will use advanced brain scans to see how a quick, 3-minute form of magnetic brain stimulation changes the brain in people with major depression. Twenty adults will receive one week of treatment and have PET and MRI scans before and after. The goal is to understand the …
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: The Royal Ottawa Mental Health Centre • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
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Can brain scans predict suicide risk in teens? new study aims to find out
Knowledge-focused Not yet recruitingThis study will use brain scans (MEG and MRI) to look at brain activity in 60 young people aged 14-24 who have either attempted suicide, have ongoing suicidal thoughts, or are healthy. The goal is to find brain patterns linked to suicide risk. High-risk participants will also rec…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Brain monitoring may sharpen ECT dosing for severe mental illness
Knowledge-focused Not yet recruitingThis study will test ways to improve how doctors choose electroconvulsive therapy (ECT) stimulation settings for people with severe depression or catatonia. Researchers will use real-time brain monitoring to measure brain activity and blood flow during ECT. The goal is to find th…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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Teen brain study: can hormone pills calm suicide risk?
Knowledge-focused Not yet recruitingThis study looks at how natural hormone changes during the menstrual cycle may make some teenage girls more irritable or depressed, especially those at risk for suicide. Researchers will give 50 girls ages 12-16 either a birth control pill to keep hormones steady or a placebo for…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE4 • Sponsor: University of North Carolina, Chapel Hill • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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DNA-Guided depression treatment tested in morocco
Knowledge-focused Not yet recruitingThis study tests whether using a person's genetic information can help doctors choose the best antidepressant for major depressive disorder. 570 adults in Morocco will be randomly assigned to either genetic-guided treatment or standard care. Researchers will track depression symp…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Mohammed V University in Rabat • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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Brain study reveals how depression meds and therapy rewire symptoms
Knowledge-focused Not yet recruitingThis study looks at how different treatments for depression—medication, talk therapy, or both—change the way symptoms like sadness, sleep problems, and low energy are connected. Researchers will track 90 adults with mild to moderate depression using smartphone surveys to see whic…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE4 • Sponsor: Goethe University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Eye test may predict who benefits from depression therapy
Knowledge-focused Not yet recruitingThis study looks at whether a simple eye test can predict how well people with treatment-resistant depression will respond to a brain stimulation therapy called TMS. Researchers will measure how the pupils react to light before and after TMS treatment in 44 adults. The goal is to…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Polytechnic Institute of Porto • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Veterans and first responders get holistic help in new wellness study
Knowledge-focused Not yet recruitingThis study looks back at data from 80 veterans and first responders who completed a 12-week program that combined mental health support, physical therapy, nutrition advice, and occupational therapy. Researchers want to see if the program helped improve sleep, anxiety, depression,…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: Baylor University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Are medical students at risk? new study to measure depression rates
Knowledge-focused Not yet recruitingThis study aims to find out how common depression is among medical students at Sohag University. Researchers will survey 300 students aged 18 to 25 to measure depression rates and understand the factors that contribute to it. The goal is to raise awareness and improve mental heal…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: Sohag University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Can magnetic pulses calm the brain in PTSD and depression?
Knowledge-focused Not yet recruitingThis study looks at how two types of noninvasive brain stimulation affect brain activity and the body's stress system in people with both PTSD and major depression. Fifty adults will receive both active and sham stimulation in random order, with brain and heart measurements taken…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Tri-Service General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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Exercise study targets hidden muscle energy problem in menopausal depression
Knowledge-focused Not yet recruitingThis study looks at whether a tailored exercise program can improve how quickly muscles recover oxygen after activity in menopausal women with depression. Researchers will compare exercise to a non-physical activity in 52 women. The goal is to understand the link between depressi…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Besancon • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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Twice the therapy, double the relief? new study tests faster sessions for depression
Knowledge-focused Not yet recruitingThis study aims to find better ways to treat depression by testing two ideas: whether having therapy twice a week instead of once leads to better results, and whether matching the type of therapy (CBT or psychodynamic) to a person's personality helps. Researchers will enroll 200 …
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of Oslo • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:05 UTC
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New study tests best method to quit antidepressants without relapse
Knowledge-focused Not yet recruitingThis study compares two strategies for safely stopping antidepressants in adults whose depression is in remission. Participants will be randomly assigned to either a standard gradual dose reduction or a more precise hyperbolic tapering method. The goal is to see which approach le…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE4 • Sponsor: Universita di Verona • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Menopause may change how antidepressants work in women
Knowledge-focused Not yet recruitingThis study looks at how menopause changes the way the body processes escitalopram, a common antidepressant. Researchers will measure drug levels in the blood of 94 women aged 40-60 who are premenopausal or menopausal and taking the medication for depression or anxiety. The goal i…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: Eskisehir Osmangazi University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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Teens watch 5-Minute videos to fight depression stigma
Knowledge-focused Not yet recruitingThis study tests whether short online videos can reduce stigma about depression and improve help-seeking attitudes in teens aged 8-18. About 500 participants, both depressed and non-depressed, will watch either a stigma-reduction video or a neutral video. The goal is to see if th…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Jian-Jun Ou • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC
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Major study aims to unlock the secrets of Treatment-Resistant depression
Knowledge-focused Not yet recruitingThis study will follow 2,000 adults with major depressive disorder or bipolar disorder to understand why some people get better with treatment and others do not. Researchers will collect information on symptoms, thinking abilities, genetics, metabolism, proteins, and immune marke…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: University of Oxford • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC