Brain monitoring may sharpen ECT dosing for severe mental illness
NCT ID NCT07561307
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study will test ways to improve how doctors choose electroconvulsive therapy (ECT) stimulation settings for people with severe depression or catatonia. Researchers will use real-time brain monitoring to measure brain activity and blood flow during ECT. The goal is to find the best method to increase stimulation and understand how different pulse settings affect the brain. Sixty-four participants already receiving ECT will be assigned to either a starting or maintenance group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Electroconvulsive therapy (ECT) - electrical stimulation under anesthesia
What this could lead to
If successful, this could lead to more personalized and effective ECT dosing, potentially improving treatment outcomes for severe depression and catatonia.
What could go wrong
This is an early-stage, small study (64 participants) focused on refining methods, not testing a new treatment. Results may not apply to all patients or settings.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for DEPRESSION - MAJOR DEPRESSIVE DISORDER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Email: •••••@•••••
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Pennsylvania Hospital
Philadelphia, Pennsylvania, 19146, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••