DEPRESSION - MAJOR DEPRESSIVE DISORDER

This study explores whether artificial intelligence (AI) can accurately identify mental health conditions like ADHD, autism, depression, and anxiety by analyzing a person's speech patterns. Researchers will collect speech samples from 500 people aged 16-60 who are being evaluated…

This study tests whether a non-invasive brain stimulation technique called accelerated theta burst stimulation (aTBS) can safely reduce symptoms of depression in people with autism spectrum disorder (ASD). Researchers will compare the active treatment to a sham (placebo) procedur…

This study tests whether Compound Ciwujia Granules, a traditional Chinese herbal medicine, can help reduce depression symptoms in people with a specific syndrome (heart-spleen deficiency). About 60 adults with major depressive disorder will take either the granules or a placebo t…

This study tests whether a robot that can be personalized by older adults helps reduce loneliness and depression better than a standard robot or usual care. About 90 people aged 65 and older living in a care community will interact with the robot for 20 minutes twice a week over …

This study tests whether a 4-month anti-inflammatory diet can reduce symptoms of anxiety and depression in 60 adults. Participants will be assigned to either the special diet or their usual eating habits. Researchers will also use AI to analyze speech and facial expressions to se…

This study tests whether a smartphone app called MENTINA can help people with current or past depression better manage their symptoms. About 660 adults from Denmark, Germany, and Spain will use the app for 12 months to track their mood and receive feedback. The goal is to see if …

This study aims to find out which brain scan patterns can predict whether a person with treatment-resistant depression will improve with theta-burst rTMS, a type of magnetic brain stimulation. Researchers will also track how the therapy affects thinking and memory. About 54 adult…

This study tests whether adding stigma-reduction counseling to standard depression treatment helps adults living with HIV in Malawi. Researchers will enroll 200 people and measure if the approach is acceptable, feasible, and improves depression symptoms and HIV care engagement. T…

This study looks at blood samples from 46 people with treatment-resistant depression who took psilocybin in a previous trial. Researchers will measure inflammation markers (cytokines) to see if they are linked to how well the treatment worked. The goal is to understand if inflamm…

This study looks at whether emphasizing certain words in a questionnaire's instructions changes how people with depression or anxiety respond. Researchers will give the same mental health survey twice in one day to 200 U.S. adults who have been diagnosed with generalized anxiety …

This study looks at how a nasal spray called esketamine helps people with severe depression who are thinking about suicide. Researchers want to know if it works by improving the ability to feel pleasure (anhedonia) and by reducing emotional pain. They are analyzing data from 456 …

This study was designed to see if a drug called LY-2940094 could protect healthy people from developing depression or anxiety after stress. Researchers planned to measure brain responses to rewards and fear using tasks and questionnaires. However, the study was withdrawn before a…

This study looks at health records of about 100,000 people in Israel to see if viral infections like COVID-19 or Epstein-Barr increase the risk of developing mental health conditions such as depression, anxiety, bipolar disorder, or schizophrenia. It also examines whether infecti…

This study tests whether a nurse-led health coaching program helps women aged 45 to 64 in Hong Kong use medical services more wisely and feel more in control of their health. About 1,728 women will either receive the nurse coaching or general health advice. The goal is to see if …

This study tracks 540 people with mood disorders (like depression or bipolar disorder) and healthy volunteers over 12 months. Participants wear a Fitbit, use a phone app to log daily mood, and complete checkups every 3 months. The goal is to see if data from phones and wearables …

This study looks at whether Black, Indigenous, and People of Color (BIPOC) face more barriers to starting or sticking with antidepressants after a one-time psychiatric consultation for depression. Researchers will survey 60 adults diagnosed with depression three months after thei…