DEPRESSION - MAJOR DEPRESSIVE DISORDER
Clinical trials for DEPRESSION - MAJOR DEPRESSIVE DISORDER explained in plain language.
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Nasal spray shows promise in rapidly reducing suicidal thoughts
Disease control OngoingThis study aims to understand how a nasal spray medication called esketamine helps reduce suicidal thoughts in people with severe depression. Researchers are analyzing data from 456 patients who previously received esketamine in clinical trials. They want to see if factors like e…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: University Hospital, Montpellier • Aim: Disease control
Last updated Mar 25, 2026 14:07 UTC
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Zapping the brain to fight depression: can scans predict who it helps?
Disease control ENROLLING_BY_INVITATIONThis study is testing a non-invasive brain stimulation therapy called theta-burst rTMS for adults with depression that hasn't improved with other treatments. Researchers will use brain scans and other tests to try to predict which patients are most likely to get better from the s…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Semmelweis University • Aim: Disease control
Last updated Mar 23, 2026 15:17 UTC
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Your voice could reveal dementia: AI study aims for early detection
Diagnosis ENROLLING_BY_INVITATIONThis study is developing an AI tool that analyzes speech recordings to help detect dementia and related conditions. Researchers will record 340 Danish-speaking participants completing memory and speech tasks to train the AI to recognize patterns linked to different diagnoses. The…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: Zealand University Hospital • Aim: Diagnosis
Last updated Apr 01, 2026 14:42 UTC
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Can your voice reveal your mental health? AI study aims to find out
Diagnosis ENROLLING_BY_INVITATIONThis study is testing whether artificial intelligence (AI) can accurately identify mental health conditions by analyzing a person's speech. Researchers will enroll 500 people aged 16-60 who are already seeking a mental health evaluation. Participants will complete short speaking …
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: Psyrin Inc. • Aim: Diagnosis
Last updated Mar 10, 2026 12:53 UTC
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New counseling aims to lift the double burden of HIV and depression stigma
Symptom relief ENROLLING_BY_INVITATIONThis study is testing a new counseling program designed to reduce the stigma surrounding HIV and mental illness. It will involve 200 adults in Malawi who are living with HIV and experiencing depression. The goal is to see if adding stigma-reduction counseling to standard depressi…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of Pennsylvania • Aim: Symptom relief
Last updated Apr 01, 2026 14:43 UTC
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Can your diet calm your mind? study tests Food's role in fighting anxiety and depression
Symptom relief ENROLLING_BY_INVITATIONThis study is testing whether following an anti-inflammatory diet for four months can help reduce symptoms of anxiety and depression, and improve physical health and thinking skills. Researchers will compare people on the special diet to a control group following their usual eati…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Universidad de Zaragoza • Aim: Symptom relief
Last updated Mar 31, 2026 12:11 UTC
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Brain zaps tested to lift depression in autistic youth
Symptom relief OngoingThis study is testing whether a non-invasive brain stimulation technique can help reduce depression in teens and young adults with autism. Researchers are comparing a real stimulation treatment to a fake (sham) treatment in 24 participants aged 13-26 who have both autism and depr…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Symptom relief
Last updated Mar 19, 2026 14:56 UTC
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Can your phone help fight depression? new app trial aims to find out
Symptom relief ENROLLING_BY_INVITATIONThis study is testing whether a smartphone app called MENTINA can help people manage symptoms of depression. Over 12 months, 660 adults with current or past depression will use the app to track their mood and receive feedback. The goal is to see if this digital tool can help peop…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital • Aim: Symptom relief
Last updated Mar 19, 2026 14:56 UTC
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Robots vs. loneliness: can a personalized companion ease depression in seniors?
Symptom relief OngoingThis study is testing whether friendly robots can help reduce loneliness and depression in older adults living in a care facility. Researchers are comparing a personalized robot interaction, a standard robot interaction, and usual care to see which works best. The goal is to see …
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: Shanghai Jiao Tong University School of Medicine • Aim: Symptom relief
Last updated Mar 05, 2026 14:00 UTC
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Could a single drug block stress from causing depression?
Knowledge-focused TerminatedThis study aimed to understand if a drug called LY-2940094 could protect healthy people from developing depression- and anxiety-like symptoms after stress. Researchers planned to give the drug to volunteers and then measure their brain's reward system and fear responses in a lab …
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: PHASE2 • Sponsor: Mclean Hospital • Aim: Knowledge-focused
Last updated Mar 31, 2026 12:12 UTC
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Your phone could warn you before depression returns
Knowledge-focused ENROLLING_BY_INVITATIONThis study aims to see if data from smartphones and Fitbits can predict when a person's depression might come back. Over 12 months, 540 people with mood disorders and healthy volunteers will wear a Fitbit and log their mood daily in an app. Researchers will use this data to build…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: Korea University Anam Hospital • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:35 UTC
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Could a virus trigger depression? massive study digs into medical records for clues
Knowledge-focused OngoingThis study aims to understand if getting certain viral infections increases a person's risk of developing mental illnesses like depression, anxiety, or schizophrenia, or causes a relapse in people who already have these conditions. Researchers will analyze the anonymized health r…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: Shalvata Mental Health Center • Aim: Knowledge-focused
Last updated Mar 30, 2026 14:30 UTC
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Magic mushroom science: could a blood test predict who it helps?
Knowledge-focused OngoingThis study is analyzing blood samples from a previous trial to understand how psilocybin (a compound in certain mushrooms) might work for treatment-resistant depression. Researchers are measuring inflammation markers in the blood to see if a person's level of inflammation before …
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Sponsor: King's College London • Aim: Knowledge-focused
Last updated Mar 27, 2026 12:38 UTC
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Can a single word change your mental health score?
Knowledge-focused OngoingThis study aims to understand if emphasizing certain words in the instructions for mental health questionnaires changes how people answer them. It involves 200 U.S. adults who have been treated for depression or anxiety in the past year. Participants will complete the same questi…
Matched conditions: DEPRESSION - MAJOR DEPRESSIVE DISORDER
Phase: NA • Sponsor: University of California, Irvine • Aim: Knowledge-focused
Last updated Mar 16, 2026 15:26 UTC