Nasal spray shows promise against suicidal thoughts – but who benefits most?

This study looks at how a nasal spray called esketamine can quickly reduce suicidal thoughts in people with severe depression. Researchers want to find out if symptoms like loss of pleasure (anhedonia) or emotional pain can predict who will benefit most. The study re-analyzes data from two earlier trials involving 456 patients. It does not test a new treatment but aims to better understand how esketamine works.