Poop pills for depression? new study tests gut bacteria fix

NCT ID NCT06692361

Recruiting now Symptom relief Sponsor: Gang Wang Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a fecal microbiota transplant (FMT) — transferring healthy gut bacteria from a donor — can help adults with major depression who aren't getting better with standard antidepressants. About 214 participants will receive either FMT or a placebo, and researchers will measure changes in depression symptoms and gut health. The goal is to see if this approach offers a new, safe way to ease depression when pills alone fall short.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION - MAJOR DEPRESSIVE DISORDER MAJOR DEPRESSIVE DISORDER (MDD)

Contacts and locations

Locations

Beijing Anding Hospital
RECRUITING

Beijing, Beijing Municipality, 100088, China
Nangfang Hospital Affiliated of Southern Medical University
NOT_YET_RECRUITING

Guangzhou, Guangdong, 510450, China
Shandong Daizhuang Hospital
RECRUITING

Jining, Shandong, 272000, China
The First Affiliated Hospital of Hebei Medical University
RECRUITING

Shijiazhuang, Hebei, 050000, China
The First Affiliated Hospital of Zhejiang University
RECRUITING

Hangzhou, Zhejiang, 310000, China
The Second People's Hospital of Dali Bai Autonomous Prefecture
RECRUITING

Dali, Yunnan, 671003, China
Tianjin Anding Hospital
RECRUITING

Tianjin, Tianjin Municipality, 300202, China
West China Hospital Affiliated of Sichuan University
RECRUITING

Chengdu, Sichuan, 610041, China
Wuhu Fourth People's Hospital
RECRUITING

Wuhu, Anhui, 241002, China

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