Could a common ADHD drug also treat depression?

NCT ID NCT06967857

Recruiting now Disease control Sponsor: Prof. Dr. Frank Behrens Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tests whether dexamfetamine, a stimulant used for ADHD, can safely and effectively treat both ADHD and moderate to severe depression in adults. 105 participants will receive either a fast-acting or long-acting version of the drug, or a placebo. The study is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: dexamfetamine sulfate
What this could lead to: If successful, this could point toward a new treatment option for people with both ADHD and depression, potentially improving focus and mood together.
What could go wrong: This is an early Phase 2 trial with only 105 participants, so results may not apply to everyone. Stimulants can cause side effects like insomnia, anxiety, or increased heart rate.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

attention deficit hyperactivity disorder, inattentive type attention deficit-hyperactivity disorder Depression major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATTENTION-DEFICIT/HYPERACTIVITY DISORDER (ADHD) DEPRESSION - MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

Department of Psychiatry, Psychosomatics and Psychotherapy University Hospital Frankfurt am Main - Goethe University
RECRUITING

Frankfurt, 60590, Germany
University Leipzig, Department of Psychiatry and Psychotherapy
RECRUITING

Leipzig, 04103, Germany

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