Could a natural hormone ease anxiety and depression in veterans?

NCT ID NCT06188923

Recruiting now Symptom relief Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 08, 2026 · Updated 2 times

Summary

This study tests whether a natural hormone called pregnenolone can improve daily functioning in veterans with anxiety and depression. 84 veterans will take either pregnenolone or a placebo for 8 weeks. The goal is to see if it helps with mood, sleep, and pain, with minimal side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pregnenolone
What this could lead to: If it works, this could point toward a new treatment option for veterans struggling with anxiety, depression, poor sleep, and chronic pain.
What could go wrong: This is an early Phase 2 trial with only 84 participants, so results may not apply to everyone. The drug may not improve function or symptoms as hoped.

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression depressive disorder mixed anxiety and depressive disorder Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANXIETY AND DEPRESSION

Contacts and locations

Locations

Durham VA Medical Center, Durham, NC
RECRUITING

Durham, North Carolina, 27705-3875, United States

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