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Magnetic pulses to the brain could lift bipolar depression

NCT ID NCT06370988

Recruiting now Symptom relief Sponsor: Centre for Addiction and Mental Health Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a non-invasive brain stimulation technique called intermittent theta-burst stimulation (iTBS) can reduce depression symptoms in people with treatment-resistant bipolar disorder. About 124 participants will receive either real or sham (fake) stimulation daily for 30 days, then be followed for 6 weeks. Researchers will measure changes in depression and mania symptoms to see if the treatment is safe and effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
intermittent theta-burst stimulation (iTBS) using a magnetic coil device
What this could lead to
If it works, this could offer a new, non-drug option to reduce depression symptoms in people with bipolar disorder who haven't responded to standard treatments.
What could go wrong
This is a mid-sized trial testing a device, not a drug, and the effect may be small or no better than placebo. The study is still recruiting, so results are uncertain.

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Conditions

The condition(s) this trial relates to.

bipolar depression bipolar disorder bipolar II disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BIPOLAR DEPRESSION BIPOLAR DISORDER TREATMENT RESISTANT BIPOLAR DISORDER TYPE 2 BIPOLAR DISORDER

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Centre for Addiction and Mental Health

    RECRUITING

    Toronto, Ontario, M6J 1H4, Canada

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

  • University Health Network

    RECRUITING

    Toronto, Ontario, M5T 2S8, Canada

    Contact

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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