Can a mindfulness app supercharge brain stimulation for depression?

NCT ID NCT07369557

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This pilot study tests whether adding brief guided mindfulness exercises (via a smartphone app) between sessions of accelerated brain stimulation (aiTBS) is feasible and acceptable for people with major depression. Twenty adults already receiving aiTBS as standard care will practice mindfulness for 5-15 minutes at a time over five treatment days. Researchers will track adherence, side effects, and changes in mood and mindfulness up to 12 weeks later.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

guided mindfulness practice via smartphone app

What this could lead to

If successful, this could point toward a way to boost the antidepressant effects of brain stimulation by adding brief mindfulness exercises.

What could go wrong

This is a very small, early pilot study (20 people) with no control group, so results may not be generalizable. Meditation-related side effects are possible.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • IOP

    RECRUITING

    Charleston, South Carolina, 29407, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Medical University of South Carolina (MUSC), Brain Stimulation Laboratory Institute of Psychiatry

    NOT_YET_RECRUITING

    Charleston, South Carolina, 29407, United States