Brain zaps for depression: which pattern works best?

NCT ID NCT06976840

Recruiting now Knowledge-focused Sponsor: Marta Peciña, MD PhD Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests three types of non-invasive brain stimulation (intermittent, continuous, and sham) in 200 adults with major depression. Participants receive each type in separate sessions while undergoing MRI scans and mood assessments. The goal is to understand how different stimulation patterns affect brain networks and mood, and how they might work with antidepressant medications.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Intermittent theta burst stimulation, continuous theta burst stimulation, and sham theta burst stimulation (all delivered via a device)
What this could lead to: If successful, this study could point toward more effective, personalized brain stimulation strategies for treating depression.
What could go wrong: This is an early-stage, observational study focused on brain activity and mood changes, not a treatment trial. Results may not lead to immediate clinical benefits.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

Bellefield Towers
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States

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