Brain zaps for bipolar blues: new hope for Treatment-Resistant depression?
NCT ID NCT06986460
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 3 trial tests whether low-frequency repetitive transcranial magnetic stimulation (rTMS) can ease depression in people with bipolar disorder who haven't improved with other treatments. Eighty adults will receive daily sessions for 30 days, with depression and mania symptoms tracked for 6 weeks afterward. The goal is to see if this non-invasive brain stimulation offers a safe, effective option for hard-to-treat bipolar depression.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
repetitive transcranial magnetic stimulation (rTMS) device
What this could lead to
If successful, this could provide a new, non-drug treatment option for people with bipolar depression who haven't responded to other therapies.
What could go wrong
This is a single-arm observational study without a placebo group, so results may be less conclusive. The treatment requires daily visits for 30 days, which may be burdensome.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Centre For Addiction and Mental Health (CAMH)
RECRUITINGToronto, Ontario, M6J 1H1, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University Health Network Toronto Western Hospital
RECRUITINGToronto, Ontario, M5T 2S8, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••