Personalized brain zaps: a new hope for tough depression?

NCT ID NCT07528157

Not yet recruiting Knowledge-focused Sponsor: Stanford University Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a brain stimulation treatment for depression called iTBS can be improved by customizing it to each person's brain signals. Researchers will use EEG to measure brain responses and find the best stimulation settings for 80 adults with treatment-resistant depression. The goal is to see if personalized settings work better than standard ones.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Intermittent theta burst stimulation (iTBS) delivered via a device
What this could lead to: If successful, this could point toward a more effective, personalized way to treat depression that doesn't respond to standard treatments.
What could go wrong: This is an early-stage study focused on measuring brain signals, not yet testing if the personalized treatment actually improves depression symptoms. The approach may not translate into better outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Depressive Disorder, Treatment-Resistant major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER TREATMENT RESISTANT DEPRESSION

Contacts and locations

Locations

Stanford University

Stanford, California, 94305, United States

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Other studies related to the condition(s) this trial covers.