New hope for depression-related daytime sleepiness? phase 3 trial underway

NCT ID NCT07484217

Recruiting now Symptom relief Sponsor: Axsome Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This study tests a drug called solriamfetol in adults with major depressive disorder who also struggle with excessive daytime sleepiness. About 508 participants will first receive the drug openly, then some will switch to a placebo to see if the drug helps prevent depressive symptoms from returning. The goal is to find out if this treatment can safely ease sleepiness and improve mood.

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Conditions

The condition(s) this trial relates to.

Disorders of Excessive Somnolence major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER WITH EXCESSIVE DAYTIME SLEEPINESS SYMPTOMS

Contacts and locations

Locations

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Tucson, Arizona, 85704, United States
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Bellflower, California, 90706, United States
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Chino, California, 91710, United States
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Glendale, California, 91206, United States
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Imperial, California, 92251, United States
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Los Angeles, California, 90015, United States
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Oceanside, California, 92056, United States
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Redlands, California, 92374, United States
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San Diego, California, 92123, United States
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Sherman Oaks, California, 91403, United States
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Walnut Creek, California, 94596, United States
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Jacksonville, Florida, 32256, United States
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Miami, Florida, 33122, United States
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Miami, Florida, 33176, United States
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Atlanta, Georgia, 30331, United States
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Norcross, Georgia, 30092, United States
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Snellville, Georgia, 30078, United States
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Chicago, Illinois, 60634, United States
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Pikesville, Maryland, 21208, United States
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Springfield, Massachusetts, 01103, United States
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Las Vegas, Nevada, 89102, United States
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Las Vegas, Nevada, 89119, United States
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Cherry Hill, New Jersey, 08002, United States
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Toms River, New Jersey, 08755, United States
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Brooklyn, New York, 11235, United States
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New York, New York, 10036, United States
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New York, New York, 10128, United States
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Staten Island, New York, 10314, United States
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The Bronx, New York, 10464, United States
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Cincinnati, Ohio, 45215, United States
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Cincinnati, Ohio, 45245, United States
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Edmond, Oklahoma, 73013, United States
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Oklahoma City, Oklahoma, 73116, United States
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Portland, Oregon, 97210, United States
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Memphis, Tennessee, 38119, United States
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Austin, Texas, 78759, United States
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Bellaire, Texas, 77401, United States
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Dallas, Texas, 75243, United States
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Houston, Texas, 77007, United States
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San Antonio, Texas, 78240, United States