Scientists probe brain networks to personalize depression treatment
NCT ID NCT05523817
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study uses a non-invasive brain stimulation technique called iTBS to explore how stimulating specific brain networks changes mood, thinking, and brain activity in people with major depression and healthy volunteers. Researchers aim to understand the brain mechanisms behind the therapeutic effects of this treatment. The study involves 80 participants and uses brain scans and cognitive tests to measure changes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Intermittent Theta Burst Stimulation (iTBS) - a non-invasive brain stimulation device
What this could lead to
If successful, this could lead to more personalized and effective brain stimulation treatments for depression.
What could go wrong
This is an early-stage study focused on understanding brain mechanisms, not testing a new treatment. It is small (80 people) and results may not apply to everyone with depression.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02129, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••