Scientists probe brain networks to personalize depression treatment

NCT ID NCT05523817

Recruiting now Knowledge-focused Sponsor: Massachusetts General Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses a non-invasive brain stimulation technique called iTBS to explore how stimulating specific brain networks changes mood, thinking, and brain activity in people with major depression and healthy volunteers. Researchers aim to understand the brain mechanisms behind the therapeutic effects of this treatment. The study involves 80 participants and uses brain scans and cognitive tests to measure changes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Intermittent Theta Burst Stimulation (iTBS) - a non-invasive brain stimulation device
What this could lead to: If successful, this could lead to more personalized and effective brain stimulation treatments for depression.
What could go wrong: This is an early-stage study focused on understanding brain mechanisms, not testing a new treatment. It is small (80 people) and results may not apply to everyone with depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02129, United States

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