New drug milsaperidone aims to boost depression treatment

NCT ID NCT06830044

Recruiting now Symptom relief Sponsor: Vanda Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 3 study tests whether adding milsaperidone to standard antidepressant therapy helps adults with major depressive disorder who still have symptoms. About 500 participants will receive either milsaperidone or a placebo, and researchers will measure changes in depression severity using a standard rating scale.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: milsaperidone (also called VHX-896)
What this could lead to: If it works, this could provide a new add-on treatment option for people with major depressive disorder who haven't gotten enough relief from standard antidepressants.
What could go wrong: This is a Phase 3 trial, but it's still experimental. The drug may not prove more effective than placebo, and side effects are possible. Results may not apply to all patients with depression.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER (MDD)

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Vanda Investigational Site
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Phoenix, Arizona, 85012, United States
Vanda Investigational Site
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Little Rock, Arkansas, 72211, United States
Vanda Investigational Site
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Garden Grove, California, 92845, United States
Vanda Investigational Site
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Lemon Grove, California, 91945, United States
Vanda Investigational Site
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Orange, California, 92868, United States
Vanda Investigational Site
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San Jose, California, 95124, United States
Vanda Investigational Site
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Walnut Creek, California, 94596, United States
Vanda Investigational Site
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Colorado Springs, Colorado, 80910, United States
Vanda Investigational Site
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Fort Myers, Florida, 33912, United States
Vanda Investigational Site
ACTIVE_NOT_RECRUITING

Miami, Florida, 33135, United States
Vanda Investigational Site
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Miami, Florida, 33173, United States
Vanda Investigational Site
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Tampa, Florida, 33614, United States
Vanda Investigational Site
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Chicago, Illinois, 60634, United States
Vanda Investigational Site
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Saint Charles, Missouri, 63304, United States
Vanda Investigational Site
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Las Vegas, Nevada, 89119, United States
Vanda Investigational Site
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New York, New York, 10035, United States
Vanda Investigational Site
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Staten Island, New York, 10314, United States
Vanda Investigational Site
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Media, Pennsylvania, 19063, United States
Vanda Investigational Site
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Richardson, Texas, 75080, United States
Vanda Investigational Site
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Witchita Falls, Texas, 76309, United States
Vanda Investigational Site
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Bellevue, Washington, 98007, United States
Vanda Investigational Site
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Sofia, 1202, Bulgaria
Vanda Investigational Site
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Sofia, 1618, Bulgaria
Vanda Investigational Site
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Sofia, 1680, Bulgaria
Vanda Investigational Site
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Targovishte, 7700, Bulgaria
Vanda Investigational Site
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Varna, 9020, Bulgaria
Vanda Investigational Site
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Brno, 60200, Czechia
Vanda Investigational Site
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Pilsen, 30100, Czechia
Vanda Investigational Site
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Poruba, 70800, Czechia
Vanda Investigational Site
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Prague, 100 00, Czechia
Vanda Investigational Site
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Prague, 15000, Czechia
Vanda Investigational Site
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Prague, 16000, Czechia
Vanda Investigational Site
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Bialystok, 15-756, Poland
Vanda Investigational Site
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Bydgoszcz, 85-794, Poland
Vanda Investigational Site
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Gdansk, 80-952, Poland
Vanda Investigational Site
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Katowice, 40-514, Poland
Vanda Investigational Site
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Katowice, 40-600, Poland
Vanda Investigational Site
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Suchy Las, 62-002, Poland

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