Personalized brain zaps could speed up depression relief

NCT ID NCT05645575

Recruiting now Symptom relief Sponsor: University of California, Los Angeles Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This pilot study tests whether a faster, personalized version of transcranial magnetic stimulation (TMS) is safe and feasible for inpatients with major depressive disorder. Thirty participants will receive up to 25 TMS sessions over two weeks, with the frequency tailored to their individual brain rhythms. The goal is to see if this approach can ease depression symptoms more quickly than standard TMS.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial Magnetic Stimulation (TMS)
What this could lead to: If it works, this could point toward a faster, more personalized TMS treatment for severe depression.
What could go wrong: This is a very small, early pilot study with only 30 participants and no control group. Results may not apply to everyone, and the treatment may not work better than standard TMS.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

major depressive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MAJOR DEPRESSIVE DISORDER

Contacts and locations

Locations

UCLA TMS Service and Research Service
RECRUITING

Los Angeles, California, 90024, United States

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