Spit test could take guesswork out of mental health prescriptions

NCT ID NCT06929533

Recruiting now Knowledge-focused Sponsor: University of Manitoba Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This pilot study is testing whether a simple saliva test can help doctors prescribe mental health medications more safely and effectively. 200 adults in Manitoba who are starting or changing psychiatric drugs will provide a DNA sample. The results will be shared with their doctor to guide drug choice and dosing. The study focuses on whether this approach is practical and acceptable, not yet on whether it improves health outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Pharmacogenetic testing (saliva-based DNA test to guide medication choice)
What this could lead to: If successful, this could show that genetic testing helps doctors pick better mental health drugs with fewer side effects, paving the way for wider use.
What could go wrong: This is a small pilot study (200 people) focused on feasibility, not proof of effectiveness. Results may not apply to everyone, and the test may not improve outcomes.

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Conditions

The condition(s) this trial relates to.

anxiety disorder bipolar disorder Depression Drug-Related Side Effects and Adverse Reactions mental disorder psychiatric disorder Psychological Well-Being Psychotic Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ADVERSE DRUG REACTION (ADR) EFFECTIVENESS MENTAL DISORDER PHARMACOGENETICS

Contacts and locations

Locations

Shared Health Facilities
NOT_YET_RECRUITING

Winnipeg, Manitoba, R3C 3H8, Canada
University of Manitoba College of Pharmacy
RECRUITING

Winnipeg, Manitoba, R3E 0T5, Canada

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