Could a blood pressure drug lift brain fog in depression?

NCT ID NCT06408246

Recruiting now Symptom relief Sponsor: Stanford University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether guanfacine, a medication typically used for blood pressure, can improve brain network function and reduce cognitive problems in people with depression. Researchers will enroll 162 adults aged 18-60 who are currently experiencing a major depressive episode. The goal is to see if the drug helps relieve depressive symptoms and improves daily functioning and quality of life.

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Conditions

The condition(s) this trial relates to.

Depression depressive disorder major depressive disorder Neurobehavioral Manifestations

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION

Contacts and locations

Locations

Stanford Psychiatry and Behavioral Sciences Department
RECRUITING

Palo Alto, California, 94305, United States
University of Illinois at Chicago
RECRUITING

Chicago, Illinois, 60607, United States

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