Stanford University

This early-stage study tests a drug called efgartigimod in 5 adults with IgG4-related disease, a condition that causes swelling in glands and organs. Participants receive weekly injections for 12 weeks to see if the drug reduces swelling in the tear glands, saliva glands, or panc…

This study compares two surgeries for Fuchs endothelial dystrophy, a condition that clouds the cornea. One group gets a standard corneal transplant (DMEK), the other gets a newer procedure that strips damaged cells and uses Ripasudil eye drops to help healing. 60 adults will be f…

This early-stage trial tests whether specially engineered immune cells (GD2CART) can be safely made and given to children and adults with a rare, aggressive brain or spinal cord tumor called H3K27M-mutant diffuse midline glioma. The study aims to see if the cells can be produced …

This study looks at whether eating more fermented foods (like yogurt, kimchi, and sauerkraut) can reduce gut inflammation and improve daily life for people with mild to moderate ulcerative colitis. About 21 adults with confirmed UC will add these foods to their diet for a period,…

This study tests whether giving radiation before surgery can completely eliminate ductal carcinoma in situ (DCIS), a very early form of breast cancer. Half of the 50 participants will have surgery right away, while the other half will receive radiation first and then have surgery…

This study tests whether extra support, including motivational interviewing and guided opioid tapering, can help people who have been on long-term opioids safely stop or reduce them after spine surgery. Some participants also receive a muscle relaxant (tizanidine) or a placebo. T…

This study tests whether a daily ergothioneine supplement can restore low levels of this nutrient in people with kidney failure who are on dialysis. Dialysis removes waste but also depletes helpful substances like ergothioneine. Researchers will measure blood levels before and af…

This early-phase study tests a new treatment called B7-H3 CAR T cells for adults with ovarian cancer that has come back and is no longer responding to standard chemotherapy. The therapy uses a patient's own immune cells, modified in a lab to better recognize and attack cancer cel…

This early-phase study tests niclosamide, a drug previously used for tapeworm infections, combined with standard chemotherapy in children whose acute myeloid leukemia (AML) has returned or not responded to treatment. The main goal is to find a safe dose and watch for side effects…

This early-stage trial tests a new treatment for children and young adults with medulloblastoma or similar brain tumors that have come back or not responded to standard therapy. The treatment uses the patient's own immune cells, modified to recognize and attack a protein called G…

This study tests a special dye that attaches to brain tumor cells and makes them glow under a camera during surgery. The goal is to help surgeons see and remove more tumor tissue while sparing healthy brain. About 46 adults with malignant glioma or vestibular schwannoma will rece…

This study tests a special dye that makes brain tumor cells glow during surgery, helping surgeons remove more of the tumor safely. About 12 children and young adults (ages 6 months to 25 years) with suspected brain tumors will receive the dye before their planned surgery. The mai…

This study tests a virtual program that teaches parents how to help their autistic children who struggle with needing things to stay the same (insistence on sameness). About 30 families with children aged 6 to 10 will participate. The goal is to see if parents can learn the techn…

This study compares two online treatments for chronic pain: an 8-week cognitive behavioral therapy program (16 hours total) and a single 2-hour pain relief skills class. Researchers want to see which one works better for reducing pain intensity and helping people get back to dail…

This study tests whether zolpidem, a sleep medication, can improve sleep in children and teens with autism. About 26 participants aged 8-17 will receive either the drug or a placebo for 8 weeks, then switch. Researchers will measure sleep quality using brain wave recordings and a…

This study compares two methods of delivering pain medicine through a nerve block after surgery: a continuous slow drip versus scheduled small doses. The goal is to see which approach provides better pain relief and reduces the need for strong opioid painkillers. The study will e…

This study looks at whether Pivotal Response Treatment (PRT) works better when done at a center or at home for young children with autism who have trouble speaking. About 120 children aged 2 to 5 will take part for 16 weeks. The goal is to see which setting helps them communicate…

This study looks at whether a treatment called DTPA chelation can help people with Gadolinium Deposition Disease (GDD), a condition caused by gadolinium from MRI contrast dyes staying in the body. About 50 adults with GDD will receive at least 5 sessions of two-day chelation ther…

This early study from Stanford University tests whether rapid, non-invasive brain stimulation can reduce hoarding symptoms. Ten adults with hoarding disorder will receive the treatment and be monitored for changes in their urge to acquire and keep items. The goal is to see if thi…

This study collects tissue and blood samples from people with stomach or esophageal cancer, as well as those at high inherited risk, to learn how genes and proteins contribute to these cancers. Researchers aim to better understand the disease, not to test a new treatment. About 1…

This study compares two types of pain medications (anti-convulsants and anti-depressants) in 450 adults with chronic pain. Unlike typical trials, it includes patients with other health problems to get results that apply to more people. The goal is to see which drug works better a…

This study tests whether data from smartphones and smartwatches can help identify teens and young adults with cancer who are struggling emotionally. About 25 participants aged 10-25 will use an app and wearable for two months. The goal is to speed up access to mental health servi…

This study aims to learn more about the cells and molecules found in fluid collected from the uterus during gynecologic surgery. Researchers will enroll 50 women to test a new collection method and analyze the samples. The goal is to better understand gynecologic diseases, not to…

This study aims to learn more about oropharyngeal carcinoma, a type of throat cancer, and its link to HPV. Researchers will collect blood samples from 1000 patients before treatment and at six follow-up visits. Tumor samples may also be taken when available. The goal is to better…

This study is a large registry that will follow 5,000 adults who receive or remove an IVC filter—a device placed in a large vein to prevent blood clots from traveling to the lungs. Researchers will review medical records to see how patients fare over the long term. The goal is to…

This study looks at how guanfacine, a medication usually used for high blood pressure, changes brain network activity in people with depression. Researchers want to understand how it affects thinking and memory problems common in depression. About 162 adults aged 18-60 with a cur…

This study tests a facial expression-based personalization engine (FPE) designed to monitor and improve engagement during at-home cognitive training in older adults at risk for Alzheimer's disease. Researchers will compare training with and without the FPE in 80 participants aged…

This study looks at whether analyzing the DNA of a patient's tumor can help doctors choose more effective treatments for advanced cancer. About 100 adults with metastatic solid tumors that have not responded to standard therapy will have their tumor DNA tested. The goal is to see…

This study tests different computer programs that analyze heart signals and images to better understand atrial fibrillation (AFib). Researchers will compare how well these methods identify problem areas in the heart during a routine procedure called ablation. The goal is to impro…

This study uses a non-invasive brain stimulation technique called TMS to see if it can change brain activity in people with schizophrenia. Researchers want to understand how the hippocampus, a brain area linked to symptoms, responds to stimulation. The goal is not to treat the co…

This study looks at whether the amount of carotenoids (natural pigments) in your skin is linked to how your immune system ages. Researchers at Stanford will measure skin carotenoid levels and compare them to signs of skin aging and blood markers of aging in 40 healthy adults. Par…