Eye drops could make fuchs surgery less invasive

NCT ID NCT05275972

Recruiting now Disease control Sponsor: Stanford University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two surgical approaches for Fuchs endothelial dystrophy, a condition that clouds the cornea. One is a full corneal transplant (DMEK), the other is a simpler procedure that removes only the diseased cells (DSO) plus Ripasudil eye drops to help healing. 60 participants will be randomly assigned to one of the two treatments. The goal is to see if the simpler surgery with drops can achieve similar vision improvement to the transplant.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Ripasudil (eye drops)
What this could lead to: If it works, this could offer a less invasive surgical option for Fuchs dystrophy, reducing recovery time and risks while maintaining good vision.
What could go wrong: This is a small, early-phase trial with only 60 participants. The drops may not work as hoped, and the less invasive surgery might not provide lasting vision improvement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Fuchs' endothelial dystrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

FUCHS FUCHS DYSTROPHY FUCHS ENDOTHELIAL DYSTROPHY

Contacts and locations

Locations

Dartmouth-Hitchcock Medical Center
RECRUITING

Lebanon, New Hampshire, 03766, United States
Legacy Devers Eye Institute
RECRUITING

Portland, Oregon, 97210, United States
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Stanford University
RECRUITING

Palo Alto, California, 94303, United States
University of California Davis
RECRUITING

Sacramento, California, 95817, United States
University of Miami
RECRUITING

Palm Beach Gardens, Florida, 33418, United States
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Wills Eye Hospital
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

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