First human trial of Lab-Grown corneal implant launches

NCT ID NCT07325097

Recruiting now Disease control Sponsor: Precise Bio Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests a new implant called PVEK for people with corneal swelling from Fuchs' dystrophy or pseudophakic bullous keratopathy. The implant uses a collagen scaffold with human corneal cells to replace damaged tissue. About 15 participants will receive the implant and be monitored for 12 months to check safety and tolerability.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PVEK corneal implant (human collagen scaffold with corneal endothelial cells)
What this could lead to: If successful, this could lead to a new treatment option for corneal swelling that reduces the need for donor tissue transplants.
What could go wrong: This is a very early Phase 1 trial with only 15 people, so it is primarily checking safety. The implant may not work well or could cause side effects like high eye pressure or rejection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bullous keratopathy corneal edema Fuchs' endothelial dystrophy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORNEAL EDEMA CORNEAL ENDOTHELIAL DYSFUNCTION FUCHS ENDOTHELIAL DYSTROPHY PSEUDOPHAKIC BULLOUS KERATOPATHY

Contacts and locations

Locations

Ophthalmological Center After S.V.Malayan
NOT_YET_RECRUITING

Yerevan, 0048, Armenia
Rambam Medical Center
RECRUITING

Haifa, 3109602, Israel
Sharei Zedek Medical Center
NOT_YET_RECRUITING

Jerusalem, Jerusalem, abecassis, Israel

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