FUCHS' ENDOTHELIAL DYSTROPHY

This study compares two types of cornea transplant surgery (DSAEK and DMEK) in 220 adults with corneal swelling from conditions like Fuchs' dystrophy or bullous keratopathy. The goal is to see which surgery provides better vision and patient satisfaction over 12 months. Participa…

This early-stage trial tests a lab-grown patch made from human corneal cells to repair the cornea's inner layer in people with mild to moderate corneal damage. About 30 participants will receive the graft to see if it is safe and can improve vision. The approach aims to reduce th…

This study tests whether briefly soaking a corneal graft in a plasma rich in growth factors (PRGF) before transplant surgery can reduce the loss of important eye cells after the operation. About 100 people with Fuchs' endothelial dystrophy or corneal edema who need a corneal tran…

This early-stage study tests a new implant called PVEK for people with corneal swelling from Fuchs' dystrophy or after cataract surgery. About 15 adults will receive the implant and be monitored for side effects and whether they need additional treatment within 6 months. The goal…

This study tests a gentler steroid eye drop plan after corneal transplant surgery to see if it prevents rejection with fewer side effects. About 342 adults getting a DMEK transplant will be randomly assigned to different steroid schedules. The goal is to find a cost-effective way…

This study compares two eye surgeries for Fuchs endothelial dystrophy, a condition that blurs vision. 60 adults will receive either a standard corneal transplant (DMEK) or a newer procedure that strips damaged cells and uses a special eye drop (Ripasudil). The goal is to see whic…

This study tests a new imaging technique called Brillouin microscopy to see if it can diagnose keratoconus and other corneal thinning conditions. Researchers will scan the corneas of healthy volunteers and patients with these diseases to compare tissue stiffness. The goal is to d…

This early-stage study tests the safety of an experimental drug called EO2002, given as an injection into the eye, for people with corneal edema (swelling of the clear front part of the eye). The study involves 12 adults with corneal swelling caused by Fuchs' dystrophy or after c…