Stanford University

This early-stage study tests whether the drug sarilumab can help people with chronic graft-versus-host disease (cGVHD) that no longer responds to the standard treatment belumosudil. cGVHD is a serious complication after a stem cell transplant where the donor's immune cells attack…

This early-phase study tests whether baricitinib, taken with a steroid-sparing medication, can reduce active inflammation in the heart caused by sarcoidosis. Ten adults with cardiac sarcoidosis will take the drug for up to 16 weeks and undergo PET scans to see if heart inflammati…

This study tests whether it is safe and feasible for certain patients to stop taking tacrolimus, an anti-rejection drug, early after a stem cell transplant. The goal is to reduce side effects while still preventing graft-versus-host disease (GVHD). About 50 adults with blood canc…

This study will test if using artificial intelligence to find calcium buildup in heart arteries from chest CT scans people already had can improve cholesterol treatment. Researchers will notify patients and their doctors about the finding, aiming to start or strengthen cholestero…

This early study tests a drug called CAEL-101/anselamimab in 5 adults with AL amyloidoma, a condition where abnormal protein builds up in tissues. The goal is to see if the drug binds to these deposits and helps shrink them. Participants will have imaging scans over 72 weeks to t…

This study tests whether a remote dietary program can help people with early to intermediate age-related macular degeneration (AMD) lower their blood sugar and increase protective nutrients called carotenoids. About 32 participants will receive coaching to improve their eating ha…

This early-stage trial tests a new drug called TS1-ASO in 5 children with Timothy Syndrome, a rare genetic condition affecting the heart and brain. The drug is given via spinal injection to see if it is safe and can improve or prevent developmental and behavioral problems. The st…

This study tests whether insulin eye drops can safely protect the optic nerve in people with open-angle glaucoma. About 90 adults will receive either the insulin drops or a placebo once daily. The goal is to see if the drops can slow vision loss without causing side effects.

This early-stage study tests whether a combination of total lymphoid irradiation and anti-thymocyte globulin, given after a standard liver transplant, can train the body to accept the new organ without needing lifelong immune-suppressing drugs. Twelve adult liver transplant recip…

This study looks at whether giving an automated insulin delivery (AID) system to children and teens within two weeks of a type 1 diabetes diagnosis helps them manage their blood sugar better and stick with the system long-term. About 16 participants will be followed for one year …

This study looks at how a surgery called CTAK (corneal tissue addition for keratoplasty) affects vision and quality of life in people with keratoconus or corneal ectasia. About 100 participants will fill out questionnaires before and after surgery. The goal is to see if the proce…

This early-phase study tests whether a mixture of 157 live bacteria from healthy stool (MITI 001) is safe for people with irritable bowel syndrome that causes diarrhea (IBS-D). About 13 adults with IBS-D and signs of gut microbiome problems will receive the treatment. The goal is…

This pilot study tests whether a gentle ultrasound treatment can safely clear harmful waste from the brain in people who have early signs of Alzheimer's but no or mild symptoms. Fifteen adults with amyloid plaques will receive repeated ultrasound sessions or a sham procedure. The…

This study tests whether adding the drug tiprelestat to standard treatment helps people with pulmonary arterial hypertension (PAH), a serious lung condition that makes the heart work harder. About 90 adults aged 18 to 75 with moderate to severe PAH will receive either tiprelestat…

This early-phase trial tests a personalized cell therapy (rapcabtagene autoleucel) in 20 adults with large B-cell lymphoma who still have traces of cancer after initial treatment. The goal is to see if the therapy can make those traces disappear, potentially lowering the risk of …

This study tests whether adding cilostazol to standard anti-clotting medication (aspirin or clopidogrel) can prevent another stroke or heart attack in people who have already had a stroke or mini-stroke. About 2,000 adults who had a stroke within the last 6 months will take cilos…

This study in Uganda will test whether giving children both the R21 malaria vaccine and two different malaria prevention medicines works better than the vaccine alone. About 1,290 children will take part. The goal is to see if the combination can reduce malaria cases more effecti…

This study tests a free online curriculum called Smart Talk, designed to teach middle and high school students about cannabis and discourage its use. Researchers will measure whether the program changes students' intentions to use cannabis and their actual use. Over 10,000 studen…

This study tests whether taking a daily low-dose aspirin and a stomach medicine (lansoprazole) can prevent preterm birth (delivery before 37 weeks) in pregnant women at high risk. About 670 women will be enrolled early in pregnancy and followed until after delivery. The goal is t…

This study tests whether replacing dirt floors with concrete in rural Bangladeshi homes can reduce stillbirths and deaths in the first month of life. Researchers will follow 196 households where a pregnant woman lives, comparing those who get concrete floors to those who keep soi…

This study tests whether automated text message reminders can encourage people with hearing loss to get hearing aids. About 190 adults who have been recommended hearing aids will receive these texts. The goal is to see if simple reminders can increase the number of people who fol…

This study tests whether placing a special amnion membrane graft under the nipple during mastectomy can reduce nipple death and improve healing. About 30 people having nipple-sparing mastectomy for gender affirmation or breast cancer prevention will take part. The graft is made f…

This study tests whether listening to specific music for 20 minutes each day over 25 days can help reduce suicidal thoughts and improve mood. Participants also learn how to use music to manage their emotions. The trial involves 28 people aged 14 to 35 who have had recent suicidal…

This study looks at whether surgically repairing a nail bed injury leads to better nail appearance and less pain compared to just cleaning and bandaging the injury. About 100 people with nail injuries will be randomly assigned to one of the two treatments. The goal is to find out…

This study looks at whether a lower dose of the medication cabergoline can safely prevent breast pain, swelling, and milk leakage in people who have a second-trimester abortion or pregnancy loss. About 36 participants will receive either 0.5 mg or 1 mg of cabergoline, and researc…

This study tests whether using brain wave (EEG) monitoring during anesthesia can reduce postoperative delirium, a common confusion that affects older adults after surgery. About 225 patients will be randomly assigned to receive either standard anesthesia or anesthesia guided by E…

This study tests a new way to study psilocybin for major depression by giving it while people are under general anesthesia. The goal is to hide the drug's noticeable effects so neither participants nor researchers know who got the real drug, making the results more reliable. Ten …

This study is testing a new audio-based game called Mystic Pets to see if it can help distract children aged 4-17 from emotional distress while they are in the hospital. About 20 children at Lucile Packard Children's Hospital will try the game and give feedback on how easy and en…

This study tests four diet strategies—cutting high-calorie foods, limiting when you eat, eating more protein, and eating more fiber—in a 12-week online weight loss program. Researchers will enroll 208 adults with overweight or obesity to see which combination helps people lose th…

This study tests whether augmented reality (AR) and virtual reality (VR) can help teenagers aged 11 to 17 overcome their fear of needles and blood. Participants will use a special headset to gradually face their fears in a safe, computer-generated environment. The goal is to redu…

This study tests whether using virtual reality (VR) or augmented reality (AR) headsets can help children aged 4-17 feel less anxious and experience less pain during minor procedures like lumbar punctures or heart catheterizations. About 200 participants will be randomly assigned …

This study explores how patient education affects the antidepressant response to a single propofol sedation session in 20 adults with major depressive disorder. Participants receive either response-focused or diagnosis-focused education about their brain signals after sedation. T…

This study tests a new online therapy platform called Teleo, designed specifically for children and teens with anxiety or mood disorders. Researchers want to see if kids are more engaged in therapy when using Teleo compared to standard video calls. About 156 children will partici…

This pilot study tests whether special shoes that vibrate can safely help people with Parkinson's disease who experience freezing of gait—a sudden inability to move their feet while walking. Researchers will enroll 20 participants to see if the vibration feedback is tolerable and…

This study tests if adding mental health support to routine baby checkups helps mothers with mild to moderate depression feel better and supports their child's development. About 440 mothers in China will either receive the extra support or standard care. Researchers will measure…

This study tests a new type of radiation called LATTICE radiotherapy against standard palliative radiation for people with metastatic cancer. The goal is to see if the new method can shrink tumors more effectively. About 80 participants with tumors larger than 2.5 cm will be enro…

This study tests a wearable ultrasound device that targets nerves through the skin to reduce pain without surgery or medication. 90 adults with chronic nerve pain will attend a single visit to receive stimulation and report their pain levels. The goal is to see if this non-invasi…

This study tests whether community health workers (called promotoras) can help Latinx patients newly diagnosed with colorectal cancer feel better and manage their care. About 60 patients will either get extra support from a health worker or just a list of resources. The goal is t…

This study tests whether personalized virtual reality stories, created by artificial intelligence, can help children feel less anxious during hospital stays and needle procedures. About 20 English-speaking children admitted for at least 24 hours will try the VR experience. Resear…

This study aims to find out whether taking acetaminophen (Tylenol) by mouth or through an IV works better for pain control after lumbar spine fusion surgery. About 180 adults will be randomly assigned to receive either oral or IV acetaminophen for 48 hours after surgery. Research…

This study looks at whether a 2-week liquid diet that is easy to digest can help adults with chronic pancreatitis who have bothersome stomach and bowel symptoms. Researchers want to see if people can stick with the diet and if they find it acceptable. The diet is a special formul…

This study tests a single 90-minute session designed to help teens aged 13-18 who have experienced trauma (like assault or accidents) and are waiting for full therapy. The session teaches coping skills and understanding of trauma reactions. Researchers want to see if this brief h…

This study tests whether a stellate ganglion block (a nerve block in the neck) can help control symptoms of Postural Tachycardia Syndrome (POTS), a condition that causes a rapid heart rate upon standing. Twenty adults with POTS will receive either the real block or a sham procedu…

This study tests whether cannabis gummies are safe and tolerable for people recovering from bladder cancer surgery. Twenty adults with non-spreading bladder cancer will take the gummies from two weeks before surgery to 30 days after. The goal is to see if they help improve qualit…

This study tests a new device called the Origin Intubation System to help doctors place breathing tubes more easily on the first try. About 15 adults having planned surgery with general anesthesia will take part. The goal is to see if the device reduces time and improves success …

This study tests whether giving a medicine called dexmedetomidine during a second-trimester dilation and evacuation (D&E) can lower the chances of severe grief and post-traumatic stress after the procedure. About 100 people having a D&E in the operating room will be randomly assi…

This study compares two well-known early autism treatments, ESDM and PRT, to see which one helps young children with autism improve their communication skills the most. About 140 children aged 2 to 5 will be randomly assigned to one of the two therapies for 24 weeks. The goal is …

This study compares two different epidural pain relief methods during labor to see which one mothers prefer. About 150 women planning a vaginal delivery will receive standard epidural care and answer short surveys about their pain and satisfaction. The goal is to find out which a…

This study tests an automated programming method for deep brain stimulation (DBS) in people with Parkinson's disease. Fifteen participants who recently had DBS surgery will try the new algorithm and perform motor tasks like walking and finger tapping. The goal is to see if the au…

This study tests if Acoustic Resonance Therapy (ART) can ease symptoms of Empty Nose Syndrome, a condition where the nose feels blocked despite open airways. ART uses sound vibrations to clear mucus and reduce inflammation. About 40 adults who have had past turbinate surgery will…

This study tests whether a virtual reality (VR) mindfulness session at the bedside can improve mental well-being and reduce anxiety in hospitalized adults. About 42 adult patients will try VR and also receive standard care, with their well-being measured before and after. The goa…

This study tests a decision-support toolkit that helps adults with type 1 diabetes prepare for moderate exercise. The toolkit uses glucose and insulin data to give personalized advice on timing, insulin doses, and carbs. Twenty adults with type 1 diabetes will try three different…

This study tests an online Spanish course that teaches parents of young children with autism how to use Pivotal Response Treatment (PRT) to improve their child's language and social skills. About 40 Spanish-speaking families with children aged 2 to 5 will take lessons over 12 wee…

This study looks at two ways to track what you eat during a 12-month online weight loss program. One group will only track high-calorie, low-nutrition foods, while the other group tracks everything and counts calories. The goal is to see if the simpler method works just as well f…

This study tests whether a short animated storytelling video can increase people's intention to get screened for colorectal cancer. About 3000 U.S. adults who have not yet been screened will watch either the video or read a plain informational text. Researchers will measure chang…

This study tests whether daily text messages written by an AI can help people be more active. Fifty adults with an iPhone and Apple Watch will receive either personalized or generic texts for 14 days. Researchers will track activity using HealthKit data to see if the AI coaching …

This study aims to find a blood test that can detect when the body is struggling with heat, and to test devices that help people cool down quickly. Researchers will have 30 healthy adults exercise in a hot lab to mimic real-world conditions. The goal is to better track and preven…

This study compares two common methods for repairing the uterus during a C-section: lifting the uterus out of the abdomen to stitch it, or stitching it while it stays inside. Researchers want to see which method causes less bleeding, less nausea, and a better experience for the m…

This study tests a new program to help Hispanic/Latino young adults who survived childhood cancer communicate better with their family and doctors. It involves 18 survivors and their support persons. The goal is to see if the program is easy to use and helpful.

This study gathers basic health information like blood pressure, heart rate, and weight from 50 adults aged 18 to 64. Researchers will use this data to create a device that can track blood pressure continuously without needles or cuffs. No treatments or medications are tested, an…

This study looks at how to best engage family members when their loved one starts treatment for a substance use disorder. Researchers will test different strategies to see which ones help family members join a support program called CRAFT. About 100 family members and their loved…

This study looks at whether giving parents educational materials, with or without extra in-person support, helps them introduce allergenic foods to their babies earlier and more often. About 92 healthy infants and their parents will take part. The goal is to find better ways for …

This study will test a new ultrasound device (Accuro 3S) that helps doctors see the spine and guide needles in real time during epidural and spinal procedures. The goal is to reduce the number of needle sticks needed and improve success rates, especially in patients where placeme…

This study looks at how implanted vagus nerve stimulation (VNS) changes brain and heart activity in 12 adults with treatment-resistant depression. Researchers will use EEG and ECG to measure brain wave patterns and heart signals. The goal is to understand how VNS works, not to te…

This study looks at how long children should stop taking Miralax before anesthesia for a combined endoscopy and colonoscopy. Researchers will measure stomach contents and colon cleanliness in 200 kids who stop Miralax 1 to 4 hours before the procedure. The goal is to find the saf…

This study tests a new online program designed to help families understand their inherited cancer risk and encourage relatives to get low-cost genetic testing. Researchers will enroll 400 people who carry a cancer-related gene change and their adult family members. The goal is to…

This study looks at whether a fun tablet game can help children and teenagers who have had an organ transplant learn why they need to take their medicines every day. Fifteen patients aged 7 to 14 will play the game and then share their thoughts in a group interview and short surv…

This study will test whether a health tracking platform can help improve frailty in 1,000 seniors over one year. Researchers will also compare different ways to measure frailty to find the best early warning signs. The goal is to learn how to prevent frailty and keep older adults…

This study tests whether a new educational program helps high school students in construction classes understand how building design impacts community health and fairness. About 40 students aged 14-18 will be randomly assigned to either the new curriculum or the standard one. Res…

This study tests a digital app designed to support women during the first 12 weeks after childbirth. Researchers want to see if new mothers find the app helpful, easy to use, and worth using. About 60 participants who have given birth will try the app and share their feedback.

This study uses smartphone sensors and health questionnaires to measure physical activity and heart health in 15,000 US adults aged 18 and older. Participants will use an app on their iOS or Android phone to track steps, heart rate, and answer health questions. The study also tes…

This study tests whether a non-invasive device that stimulates the vagus nerve can improve memory formation in healthy older adults (ages 65-80) compared to younger adults (ages 18-30). Researchers will also explore how gut health and early signs of Alzheimer's disease affect the…

This study tests a digital program called WONE that uses short activities and wearable data to help people manage stress and build resilience. Researchers will enroll 260 Stanford-affiliated adults to see if the app is easy to use and improves well-being. The goal is to learn whe…

This study aims to understand how medications used during medical procedures affect patients' feelings of liking or disliking the drug. About 100 adults scheduled for surgery will rate their drug liking and have their brain activity measured. The results will help doctors better …

This study tests whether a brain stimulation treatment for depression can be improved by customizing it to each person. Researchers will use brain wave measurements (EEG) to find the best stimulation settings for each participant. The study involves 80 adults with treatment-resis…

This observational study will test if a noninvasive finger monitor can predict how well pregnant women, including those with severe preeclampsia, respond to fluids. Researchers will compare the finger device's readings to standard heart ultrasound results during a leg-raising tes…

This study looks at whether having dialysis on the same day as surgery is safe and practical for people with end-stage kidney disease. About 30 adults who are on a regular dialysis schedule and need non-emergency surgery will be randomly assigned to receive dialysis on the day of…

This study looks at how the brain changes when visual information is turned into patterns of sound or touch. Researchers will use brain scans and simple tasks to see if blind and sighted people can learn to use these signals. The goal is to understand how the brain adapts to new …